Detailed information of TA system TA040302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1240191..1240732
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCV39_RS05710
• Protein ID: WP_261889223.1
• Coordinates: 1240191..1240481 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: OCV39_RS05715
• Protein ID: WP_261889224.1
• Coordinates: 1240490..1240732 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS05680	1235358..1235600	-	243	WP_261889224.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
OCV39_RS05685	1235838..1236485	+	648	WP_261889225.1	HAD family phosphatase	-
OCV39_RS05690	1237156..1237416	+	261	WP_171757638.1	hypothetical protein	-
OCV39_RS05695	1237592..1238230	+	639	WP_261889226.1	hypothetical protein	-
OCV39_RS05700	1238407..1238991	+	585	WP_017082416.1	hypothetical protein	-
OCV39_RS05705	1239106..1239447	+	342	WP_261889227.1	hypothetical protein	-
OCV39_RS05710	1240191..1240481	-	291	WP_261889223.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS05715	1240490..1240732	-	243	WP_261889224.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV39_RS05720	1241537..1241896	+	360	WP_261889228.1	GFA family protein	-
OCV39_RS05725	1242037..1242684	+	648	WP_261889225.1	HAD family phosphatase	-
OCV39_RS05730	1242832..1243341	+	510	WP_261889221.1	hypothetical protein	-
OCV39_RS05735	1243487..1243891	+	405	WP_261889229.1	GFA family protein	-
OCV39_RS05740	1244029..1244691	+	663	WP_261889230.1	hypothetical protein	-
OCV39_RS05745	1244889..1245146	+	258	WP_261889231.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
OCV39_RS05750	1245134..1245436	+	303	WP_261889232.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-48)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11099.72 Da
• Isoelectric Point: 9.6601

>T40302 WP_261889223.1 NZ_AP025472:c1240481-1240191 [Vibrio cortegadensis]
MQYKLSKLAQAHLHKIKNYTVTNFSEMQWNTYKNTLLTGFQMLAENPAVGRNCNDLYQNGFYFPIGKHTAYFTKEDGFIL
VVAVLGQSQLPQNHLR

Nucleotide

• Length: 291 bp

>T40302 NZ_AP025472:c1240481-1240191 [Vibrio cortegadensis]
ATGCAATATAAACTAAGTAAATTAGCACAGGCTCATTTGCACAAAATCAAAAATTATACAGTTACGAATTTTTCCGAAAT
GCAGTGGAACACATACAAAAATACACTTCTTACTGGATTTCAGATGCTCGCTGAAAACCCCGCAGTAGGCAGAAACTGCA
ACGATTTATATCAAAATGGATTTTATTTCCCGATTGGTAAACACACAGCGTACTTTACCAAGGAAGACGGCTTTATTTTA
GTCGTTGCAGTTCTTGGACAATCGCAACTTCCACAAAACCATCTACGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8998.19 Da
• Isoelectric Point: 5.0758

>AT40302 WP_261889224.1 NZ_AP025472:c1240732-1240490 [Vibrio cortegadensis]
MHTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELETMKADYIKHCFESAKADLAQGNVVDGENFLNAL

Nucleotide

• Length: 243 bp

>AT40302 NZ_AP025472:c1240732-1240490 [Vibrio cortegadensis]
ATGCATACATTAACAGCAAATGATGCCAAACGTAATTTCGGAGAGCTGCTTCTCAACGCTCAACGTGAGCCAGTTAAGAT
AAGTAAAAATAACAAAGATGCCGTTGTGGTGATGTCGATTAGAGACTATGAAGAGCTCGAAACTATGAAAGCCGATTACA
TCAAGCATTGCTTTGAGTCTGCAAAAGCAGACTTAGCCCAAGGCAATGTAGTTGATGGTGAAAATTTCCTAAACGCGTTG
TAA