Detailed information of TA system TA040301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1235060..1235600
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCV39_RS05675
• Protein ID: WP_261889223.1
• Coordinates: 1235060..1235350 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: OCV39_RS05680
• Protein ID: WP_261889224.1
• Coordinates: 1235358..1235600 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS05640	1230299..1231132	+	834	WP_261889217.1	DUF2971 domain-containing protein	-
OCV39_RS05645	1231147..1231239	+	93	Protein_1079	DUF3265 domain-containing protein	-
OCV39_RS05650	1231279..1231926	+	648	WP_261889218.1	hypothetical protein	-
OCV39_RS05655	1232073..1232567	+	495	WP_261889219.1	GNAT family N-acetyltransferase	-
OCV39_RS05660	1232720..1233193	+	474	WP_261889220.1	GrpB family protein	-
OCV39_RS05665	1233340..1233849	+	510	WP_261889221.1	hypothetical protein	-
OCV39_RS05670	1234009..1234890	+	882	WP_261889222.1	NAD(P)-dependent oxidoreductase	-
OCV39_RS05675	1235060..1235350	-	291	WP_261889223.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS05680	1235358..1235600	-	243	WP_261889224.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV39_RS05685	1235838..1236485	+	648	WP_261889225.1	HAD family phosphatase	-
OCV39_RS05690	1237156..1237416	+	261	WP_171757638.1	hypothetical protein	-
OCV39_RS05695	1237592..1238230	+	639	WP_261889226.1	hypothetical protein	-
OCV39_RS05700	1238407..1238991	+	585	WP_017082416.1	hypothetical protein	-
OCV39_RS05705	1239106..1239447	+	342	WP_261889227.1	hypothetical protein	-
OCV39_RS05710	1240191..1240481	-	291	WP_261889223.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-48)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11099.72 Da
• Isoelectric Point: 9.6601

>T40301 WP_261889223.1 NZ_AP025472:c1235350-1235060 [Vibrio cortegadensis]
MQYKLSKLAQAHLHKIKNYTVTNFSEMQWNTYKNTLLTGFQMLAENPAVGRNCNDLYQNGFYFPIGKHTAYFTKEDGFIL
VVAVLGQSQLPQNHLR

Nucleotide

• Length: 291 bp

>T40301 NZ_AP025472:c1235350-1235060 [Vibrio cortegadensis]
ATGCAATATAAACTAAGTAAATTAGCACAGGCTCATTTGCACAAAATCAAAAATTATACAGTTACGAATTTTTCCGAAAT
GCAGTGGAACACATACAAAAATACACTTCTTACTGGATTTCAGATGCTCGCTGAAAACCCCGCAGTAGGCAGAAACTGCA
ACGATTTATATCAAAATGGATTTTATTTCCCGATTGGTAAACACACAGCGTACTTTACCAAGGAAGACGGCTTTATTTTA
GTCGTTGCAGTTCTTGGACAATCGCAACTTCCACAAAACCATCTACGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8998.19 Da
• Isoelectric Point: 5.0758

>AT40301 WP_261889224.1 NZ_AP025472:c1235600-1235358 [Vibrio cortegadensis]
MHTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELETMKADYIKHCFESAKADLAQGNVVDGENFLNAL

Nucleotide

• Length: 243 bp

>AT40301 NZ_AP025472:c1235600-1235358 [Vibrio cortegadensis]
ATGCATACATTAACAGCAAATGATGCCAAACGTAATTTCGGAGAGCTGCTTCTCAACGCTCAACGTGAGCCAGTTAAGAT
AAGTAAAAATAACAAAGATGCCGTTGTGGTGATGTCGATTAGAGACTATGAAGAGCTCGAAACTATGAAAGCCGATTACA
TCAAGCATTGCTTTGAGTCTGCAAAAGCAGACTTAGCCCAAGGCAATGTAGTTGATGGTGAAAATTTCCTAAACGCGTTG
TAA