Detailed information of TA system TA040299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1209459..1210018
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV39_RS05530
• Protein ID: WP_261889202.1
• Coordinates: 1209459..1209737 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1E5CTZ0
• Locus tag: OCV39_RS05535
• Protein ID: WP_017051427.1
• Coordinates: 1209734..1210018 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS05500	1204479..1204904	+	426	WP_261889196.1	GNAT family N-acetyltransferase	-
OCV39_RS05505	1205043..1205864	+	822	WP_261889197.1	HNH endonuclease signature motif containing protein	-
OCV39_RS05510	1206003..1206905	+	903	WP_261889198.1	hypothetical protein	-
OCV39_RS05515	1207014..1207745	+	732	WP_261889199.1	hypothetical protein	-
OCV39_RS05520	1207892..1208476	+	585	WP_261889200.1	hypothetical protein	-
OCV39_RS05525	1208638..1209216	-	579	WP_261889201.1	hypothetical protein	-
OCV39_RS05530	1209459..1209737	-	279	WP_261889202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS05535	1209734..1210018	-	285	WP_017051427.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OCV39_RS05540	1210312..1210755	-	444	WP_261889203.1	hypothetical protein	-
OCV39_RS05545	1211543..1212121	+	579	WP_261889204.1	hypothetical protein	-
OCV39_RS05550	1212091..1212174	+	84	Protein_1060	DUF3265 domain-containing protein	-
OCV39_RS05555	1212706..1213125	-	420	WP_017052207.1	BLUF domain-containing protein	-
OCV39_RS05560	1213361..1214221	+	861	WP_261889205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10949.61 Da
• Isoelectric Point: 4.2698

>T40299 WP_261889202.1 NZ_AP025472:c1209737-1209459 [Vibrio cortegadensis]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDEIIEDKVENLLEQPLMGVQRDDIRGRLLIIPEISMIISYWVDGSIIRVM
RVLHQKQKFPAN

Nucleotide

• Length: 279 bp

>T40299 NZ_AP025472:c1209737-1209459 [Vibrio cortegadensis]
ATGATTTTATGGGAAGAAGAATCATTGAATGATCGTGAGAAAATATTTGAATTTCTTTATGACTTCAACCCTGACGCAGC
TGAAAAGACTGACGAAATCATTGAAGATAAAGTTGAAAACTTACTTGAACAACCTTTAATGGGTGTTCAACGAGATGATA
TTCGAGGCCGATTACTAATTATCCCCGAAATCTCTATGATCATTTCATACTGGGTCGATGGTTCAATTATTCGTGTAATG
CGAGTTCTACATCAAAAGCAAAAATTTCCTGCAAACTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10997.31 Da
• Isoelectric Point: 8.0774

>AT40299 WP_017051427.1 NZ_AP025472:c1210018-1209734 [Vibrio cortegadensis]
MDTRIQFRIDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDSWITEQVNLAFEKFDSGKATFVDHDSAKTR
MAERKAKIRNRGHQ

Nucleotide

• Length: 285 bp

>AT40299 NZ_AP025472:c1210018-1209734 [Vibrio cortegadensis]
ATGGATACTAGAATTCAATTCCGTATTGATGACGAAATTAAACGCTTAGCTCAACAAATGGCGGAGAGCCAAGGTCGTAC
ACTTAGCGATGCTTGCCGTGAGCTTACAGAGCAAATGGCGGAGCAACAACGAAAAACATTATCTCATGACTCTTGGATAA
CTGAACAAGTAAACTTAGCATTTGAGAAATTCGACTCCGGGAAAGCTACATTTGTTGATCATGACTCAGCAAAAACTAGA
ATGGCTGAACGAAAAGCTAAAATTCGCAATCGAGGCCATCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1E5CTZ0