Detailed information of TA system TA040296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1490755..1491268
• Replicon: chromosome
• Accession: NZ_AP025471
• Organism: Vibrio coralliirubri strain DSM 27495

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV20_RS23395
• Protein ID: WP_017069754.1
• Coordinates: 1491002..1491268 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B1C1X1
• Locus tag: OCV20_RS23390
• Protein ID: WP_017061616.1
• Coordinates: 1490755..1491012 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV20_RS23370	1486853..1487260	-	408	WP_017061620.1	hypothetical protein	-
OCV20_RS23375	1487400..1488731	-	1332	WP_086774490.1	ferric reductase-like transmembrane domain-containing protein	-
OCV20_RS23380	1488967..1489656	+	690	WP_086774491.1	flavin reductase	-
OCV20_RS23385	1489777..1490568	+	792	WP_086774492.1	hypothetical protein	-
OCV20_RS23390	1490755..1491012	+	258	WP_017061616.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OCV20_RS23395	1491002..1491268	+	267	WP_017069754.1	Txe/YoeB family addiction module toxin	Toxin
OCV20_RS23400	1491300..1491623	+	324	WP_086774493.1	DUF4144 domain-containing protein	-
OCV20_RS23405	1491779..1493107	-	1329	WP_010432780.1	anaerobic C4-dicarboxylate transporter	-
OCV20_RS23410	1493519..1494178	+	660	WP_010432777.1	HAD family phosphatase	-
OCV20_RS23415	1494343..1494969	+	627	WP_086774494.1	HD domain-containing protein	-
OCV20_RS23420	1495013..1495540	+	528	WP_086774495.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10524.97 Da
• Isoelectric Point: 9.3651

>T40296 WP_017069754.1 NZ_AP025471:1491002-1491268 [Vibrio coralliirubri]
MTNDRKIVFTDNAWEDYLYWQTQDKKTLKKLNKLIEAAKRTPFEGIGKPEPLVGNLSGFWSRRIDDKNRLVYKADDDNFY
IIACRHHY

Nucleotide

• Length: 267 bp

>T40296 NZ_AP025471:1491002-1491268 [Vibrio coralliirubri]
ATGACGAATGATCGAAAAATTGTATTTACAGATAATGCTTGGGAAGATTACCTATACTGGCAAACCCAAGACAAGAAAAC
GCTCAAGAAACTAAATAAGTTGATTGAAGCCGCCAAAAGAACGCCCTTTGAAGGGATTGGAAAGCCGGAGCCACTAGTCG
GCAACCTATCTGGCTTTTGGTCAAGACGAATCGATGACAAGAATCGATTAGTGTATAAAGCAGATGACGATAACTTTTAC
ATAATTGCTTGTCGTCACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9534.55 Da
• Isoelectric Point: 4.1353

>AT40296 WP_017061616.1 NZ_AP025471:1490755-1491012 [Vibrio coralliirubri]
MNIVSFTEARNSLKSVLDRVVDDSDVTVITRRDSEDAVVMSLDHFNSMQETLYLMSSPKNAERLAESIAQLEAGNTTVRE
LNNDE

Nucleotide

• Length: 258 bp

>AT40296 NZ_AP025471:1490755-1491012 [Vibrio coralliirubri]
ATGAATATTGTTTCTTTTACTGAGGCCAGAAATAGCCTTAAGTCTGTGCTCGATAGAGTGGTAGACGATTCTGATGTTAC
GGTAATAACCAGACGAGATTCAGAAGATGCAGTGGTCATGTCTCTTGATCATTTTAATTCAATGCAAGAAACCTTGTACC
TAATGAGCTCGCCTAAAAACGCTGAAAGATTGGCTGAATCCATTGCTCAACTCGAAGCCGGAAATACAACCGTTCGAGAA
TTGAATAATGACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1C1X1