Detailed information of TA system TA040294

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 258006..258571
• Replicon: chromosome
• Accession: NZ_AP025471
• Organism: Vibrio coralliirubri strain DSM 27495

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A916ASF8
• Locus tag: OCV20_RS17785
• Protein ID: WP_005445239.1
• Coordinates: 258284..258571 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: OCV20_RS17780
• Protein ID: WP_000086647.1
• Coordinates: 258006..258287 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV20_RS17760	253115..255697	+	2583	WP_086774781.1	nitrate reductase	-
OCV20_RS17765	256029..256538	+	510	WP_086774782.1	hypothetical protein	-
OCV20_RS17770	256610..257790	+	1181	WP_102445278.1	IS3-like element ISVisp1 family transposase	-
OCV20_RS17775	257823..257915	+	93	WP_202910162.1	DUF3265 domain-containing protein	-
OCV20_RS17780	258006..258287	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV20_RS17785	258284..258571	+	288	WP_005445239.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV20_RS17790	258599..258691	+	93	WP_078555087.1	DUF3265 domain-containing protein	-
OCV20_RS17795	258924..259952	-	1029	WP_086774218.1	IS110 family transposase	-
OCV20_RS17800	260051..260596	+	546	WP_086774219.1	hypothetical protein	-
OCV20_RS17805	260749..261267	+	519	WP_086774220.1	GNAT family N-acetyltransferase	-
OCV20_RS17810	261333..261731	-	399	WP_048613463.1	hypothetical protein	-
OCV20_RS17815	261828..263399	-	1572	WP_086774221.1	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	256610..259952	3342

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11031.70 Da
• Isoelectric Point: 5.1098

>T40294 WP_005445239.1 NZ_AP025471:258284-258571 [Vibrio coralliirubri]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T40294 NZ_AP025471:258284-258571 [Vibrio coralliirubri]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAACCCACCTGC
AGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCACACGAACTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATCCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT40294 WP_000086647.1 NZ_AP025471:258006-258287 [Vibrio coralliirubri]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT40294 NZ_AP025471:258006-258287 [Vibrio coralliirubri]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0