Detailed information of TA system TA040293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 397041..397569
• Replicon: chromosome
• Accession: NZ_AP025466
• Organism: Vibrio chagasii strain LMG 21353

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV52_RS17730
• Protein ID: WP_137409201.1
• Coordinates: 397279..397569 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: OCV52_RS17725
• Protein ID: WP_005377003.1
• Coordinates: 397041..397289 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV52_RS17685	392556..392942	-	387	WP_102425072.1	hypothetical protein	-
OCV52_RS17690	393007..393321	-	315	WP_105023318.1	N(4)-acetylcytidine aminohydrolase	-
OCV52_RS17695	393368..394225	-	858	WP_102425074.1	LysR family transcriptional regulator	-
OCV52_RS17700	394312..394551	+	240	WP_137407626.1	DUF2798 domain-containing protein	-
OCV52_RS17705	394544..394831	+	288	WP_102425075.1	putative quinol monooxygenase	-
OCV52_RS17710	394919..395287	-	369	WP_137407625.1	Imm39 family immunity protein	-
OCV52_RS17715	395407..396561	+	1155	WP_261900867.1	IS110 family transposase	-
OCV52_RS17720	396898..396966	-	69	WP_074531725.1	DUF3265 domain-containing protein	-
OCV52_RS17725	397041..397289	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV52_RS17730	397279..397569	+	291	WP_137409201.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV52_RS17735	397591..397668	-	78	WP_140073191.1	DUF3265 domain-containing protein	-
OCV52_RS17740	397717..398499	-	783	WP_150897872.1	SAM-dependent methyltransferase	-
OCV52_RS17745	398643..399536	+	894	Protein_373	IS110 family transposase	-
OCV52_RS17750	399751..400779	-	1029	WP_102459962.1	IS110 family transposase	-
OCV52_RS17755	400862..401266	-	405	WP_137409187.1	DUF1801 domain-containing protein	-
OCV52_RS17760	401379..401978	-	600	WP_137409188.1	DUF3885 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	395407..407652	12245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11275.28 Da
• Isoelectric Point: 10.5932

>T40293 WP_137409201.1 NZ_AP025466:397279-397569 [Vibrio chagasii]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDIYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T40293 NZ_AP025466:397279-397569 [Vibrio chagasii]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATAGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATATTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT40293 WP_005377003.1 NZ_AP025466:397041-397289 [Vibrio chagasii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT40293 NZ_AP025466:397041-397289 [Vibrio chagasii]
ATGACCACTAGAATTTTAGCCGATGTCGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCGGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A347UR02