Detailed information of TA system TA040292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1226699..1227212
• Replicon: chromosome
• Accession: NZ_AP025464
• Organism: Vibrio celticus strain CECT 7224

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV19_RS21440
• Protein ID: WP_019821272.1
• Coordinates: 1226946..1227212 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B1C1X1
• Locus tag: OCV19_RS21435
• Protein ID: WP_017061616.1
• Coordinates: 1226699..1226956 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV19_RS21415	1222799..1223206	-	408	WP_017061620.1	hypothetical protein	-
OCV19_RS21420	1223346..1224677	-	1332	WP_065675315.1	ferric reductase-like transmembrane domain-containing protein	-
OCV19_RS21425	1224911..1225600	+	690	WP_065675316.1	flavin reductase	-
OCV19_RS21430	1225721..1226512	+	792	WP_050653202.1	hypothetical protein	-
OCV19_RS21435	1226699..1226956	+	258	WP_017061616.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OCV19_RS21440	1226946..1227212	+	267	WP_019821272.1	Txe/YoeB family addiction module toxin	Toxin
OCV19_RS21445	1227244..1228510	-	1267	Protein_1018	IS4 family transposase	-
OCV19_RS21450	1228642..1228965	+	324	WP_050647471.1	DUF4144 domain-containing protein	-
OCV19_RS21455	1229068..1230396	-	1329	WP_010432780.1	anaerobic C4-dicarboxylate transporter	-
OCV19_RS21460	1230808..1231467	+	660	WP_010432777.1	HAD family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.06 Da
• Isoelectric Point: 9.3651

>T40292 WP_019821272.1 NZ_AP025464:1226946-1227212 [Vibrio celticus]
MTNDRKIVFTDNAWEDYLYWQTQDKKTLKKLNKLIEAAKRMPFEGIGKPEPLVGNLSGFWSRRIDDKNRLVYKADDDNFY
IIACRHHY

Nucleotide

• Length: 267 bp

>T40292 NZ_AP025464:1226946-1227212 [Vibrio celticus]
ATGACGAATGATCGAAAGATTGTATTTACAGATAATGCTTGGGAAGATTACCTATACTGGCAAACCCAAGACAAGAAAAC
GCTCAAGAAACTAAATAAGTTGATTGAAGCTGCCAAAAGAATGCCCTTTGAAGGGATTGGAAAGCCGGAGCCACTAGTCG
GCAACCTGTCTGGCTTTTGGTCAAGACGAATCGATGACAAGAATCGATTAGTGTATAAAGCAGATGACGATAACTTTTAC
ATAATTGCTTGTCGTCACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9534.55 Da
• Isoelectric Point: 4.1353

>AT40292 WP_017061616.1 NZ_AP025464:1226699-1226956 [Vibrio celticus]
MNIVSFTEARNSLKSVLDRVVDDSDVTVITRRDSEDAVVMSLDHFNSMQETLYLMSSPKNAERLAESIAQLEAGNTTVRE
LNNDE

Nucleotide

• Length: 258 bp

>AT40292 NZ_AP025464:1226699-1226956 [Vibrio celticus]
ATGAATATTGTTTCTTTTACTGAGGCCAGAAATAGCCTTAAGTCTGTGCTCGATAGAGTGGTAGACGATTCTGATGTTAC
GGTAATAACCAGACGCGATTCAGAAGATGCCGTGGTAATGTCTCTTGATCATTTTAATTCAATGCAAGAAACCTTGTACC
TAATGAGCTCGCCTAAAAACGCTGAAAGATTGGCTGAATCCATTGCTCAACTCGAAGCCGGAAATACAACCGTTCGAGAA
TTGAATAATGACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1C1X1