Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2879376..2880940 Replicon chromosome
Accession NZ_AP025463
Organism Vibrio celticus strain CECT 7224

Toxin (Protein)


Gene name hipA Uniprot ID A0A1C3JLE1
Locus tag OCV19_RS12965 Protein ID WP_065677869.1
Coordinates 2879624..2880940 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1C3JL30
Locus tag OCV19_RS12960 Protein ID WP_050651471.1
Coordinates 2879376..2879624 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV19_RS12935 2874891..2876069 + 1179 WP_139093607.1 hypothetical protein -
OCV19_RS12940 2876178..2876363 - 186 Protein_2470 IS3 family transposase -
OCV19_RS12945 2876420..2876667 + 248 Protein_2471 transposase -
OCV19_RS12950 2877156..2877491 - 336 WP_065677867.1 hypothetical protein -
OCV19_RS12955 2877692..2878525 + 834 WP_065677868.1 hypothetical protein -
OCV19_RS12960 2879376..2879624 + 249 WP_050651471.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OCV19_RS12965 2879624..2880940 + 1317 WP_065677869.1 type II toxin-antitoxin system HipA family toxin Toxin
OCV19_RS12970 2881070..2882950 - 1881 WP_065677870.1 RimK/LysX family protein -
OCV19_RS12975 2883256..2884065 - 810 WP_065677871.1 M15 family metallopeptidase -
OCV19_RS12980 2884166..2884894 - 729 WP_065677872.1 DUF429 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49399.68 Da        Isoelectric Point: 7.0222

>T40291 WP_065677869.1 NZ_AP025463:2879624-2880940 [Vibrio celticus]
MQLLNAYMNGELVGTLTKQNNGSHEFKYNESWLSSDKSRPLSLSLKLQIPTITSDAVINYFDNLLPDNIAIRNRIVARYQ
TASNQPFDLLKEIGKDSVGAIALLPPSQPYIENKLSYELLDESRLEKILAAHHSDIPLGMIKEEDDFRISVAGAQEKTAL
LRLNGDWCLPKGNTPTSHIIKLPIGEIKQPTSILDLTESVENEFICIELARELGFDVPTVEIITTHNYKAIAVERFDRRW
IKDRTHLLRLPQEDICQAKGIPSSIKYESDGGPGIADIMKLLEGSSNALEDRYNFMKFQVFQWAIGAIDGHAKNYSIFIE
KQGSYRLTPFYDILSAYPITEKKGLNIRKLKLAMGLKASRGKKYQISKIYSRHFLDTAHSVGFNSDSMQSILDDMQTELP
KAIERLAARLPEGFPKHITEAIFDNSIAMLNKLNLGKN

Download         Length: 1317 bp

>T40291 NZ_AP025463:2879624-2880940 [Vibrio celticus]
ATGCAACTACTTAATGCCTATATGAATGGTGAGTTGGTCGGTACTCTAACAAAGCAAAACAATGGCTCTCATGAATTTAA
ATATAATGAGTCTTGGCTAAGTAGCGACAAATCTCGCCCATTGTCTTTATCCCTTAAACTACAAATACCTACGATAACTT
CTGATGCCGTTATCAACTACTTTGACAACCTGCTACCAGACAATATTGCTATACGTAATAGGATTGTTGCACGCTATCAA
ACGGCTTCAAATCAACCTTTTGATCTTCTAAAAGAAATTGGCAAAGACAGCGTTGGTGCCATTGCTCTGCTCCCTCCAAG
TCAACCCTATATCGAGAACAAACTGTCATACGAACTTCTTGATGAATCTCGGCTTGAAAAAATCTTAGCAGCCCATCATT
CCGATATTCCATTAGGTATGATTAAGGAAGAAGATGATTTCCGAATATCGGTTGCTGGCGCTCAAGAAAAAACAGCATTA
CTAAGGTTGAATGGAGATTGGTGTTTGCCTAAAGGGAATACACCTACAAGCCATATCATTAAGCTACCTATTGGTGAGAT
TAAGCAGCCCACCTCTATTCTAGATCTGACTGAAAGTGTCGAGAATGAGTTCATATGTATTGAGTTAGCTAGAGAGTTGG
GGTTTGATGTTCCGACAGTCGAGATCATCACAACCCATAATTATAAAGCCATTGCTGTTGAGCGTTTTGATAGACGTTGG
ATTAAGGATCGTACACACCTACTGCGCCTTCCTCAGGAAGATATCTGTCAAGCCAAAGGAATCCCTTCATCGATAAAATA
CGAAAGTGATGGAGGCCCCGGAATCGCCGATATCATGAAGCTACTTGAAGGCTCATCAAATGCACTGGAAGACAGATATA
ACTTCATGAAGTTTCAAGTTTTCCAATGGGCTATAGGCGCTATTGATGGGCATGCAAAGAACTATTCAATATTTATTGAA
AAGCAAGGTAGTTACCGCTTAACACCATTTTATGACATTTTGTCTGCTTACCCTATCACCGAAAAAAAAGGACTAAACAT
CAGAAAGTTAAAGTTAGCAATGGGGTTAAAAGCAAGCCGTGGTAAGAAATACCAGATAAGCAAGATCTACTCCCGCCACT
TTCTTGATACAGCCCATTCAGTTGGCTTTAATTCTGATAGCATGCAAAGCATATTGGATGACATGCAAACTGAATTACCC
AAAGCAATTGAGCGCCTCGCCGCACGCTTACCTGAAGGTTTCCCAAAACACATAACCGAAGCTATCTTTGATAACTCTAT
TGCCATGCTTAACAAATTGAATTTGGGCAAGAACTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9444.86 Da        Isoelectric Point: 9.7278

>AT40291 WP_050651471.1 NZ_AP025463:2879376-2879624 [Vibrio celticus]
VIYSPQQLANTLLLIRQKNRWTQSELAKKVGIKQATISNFENRPEKATISTMFKLIQALDLTLKIEPKDVKNSQSTVDEE
DW

Download         Length: 249 bp

>AT40291 NZ_AP025463:2879376-2879624 [Vibrio celticus]
GTGATTTATAGCCCACAACAATTAGCTAATACTTTACTGCTAATACGCCAAAAGAATAGATGGACTCAGTCTGAGCTGGC
AAAAAAAGTAGGGATAAAACAAGCAACCATTTCGAACTTTGAAAATAGACCAGAAAAGGCCACTATTTCAACAATGTTCA
AGCTCATACAAGCATTAGATCTCACCCTTAAAATAGAACCCAAAGATGTAAAAAATAGTCAAAGCACTGTTGATGAGGAA
GATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C3JLE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3JL30

References