Detailed information of TA system TA040289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 110653..111166
• Replicon: chromosome
• Accession: NZ_AP025461
• Organism: Vibrio atlanticus strain CECT 7223

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV30_RS16225
• Protein ID: WP_017069754.1
• Coordinates: 110900..111166 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B1C1X1
• Locus tag: OCV30_RS16220
• Protein ID: WP_017061616.1
• Coordinates: 110653..110910 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV30_RS16195	105679..106440	+	762	WP_102552608.1	IS5 family transposase	-
OCV30_RS16200	106589..108031	+	1443	WP_065680219.1	N-acylglucosamine 2-epimerase	-
OCV30_RS16205	108240..108647	-	408	WP_026012354.1	hypothetical protein	-
OCV30_RS16210	108889..109590	+	702	WP_065680218.1	flavin reductase	-
OCV30_RS16215	109676..110467	+	792	WP_065680217.1	hypothetical protein	-
OCV30_RS16220	110653..110910	+	258	WP_017061616.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OCV30_RS16225	110900..111166	+	267	WP_017069754.1	Txe/YoeB family addiction module toxin	Toxin
OCV30_RS16230	111198..111521	+	324	WP_065680216.1	DUF4144 domain-containing protein	-
OCV30_RS16235	111615..112943	-	1329	WP_004732879.1	anaerobic C4-dicarboxylate transporter	-
OCV30_RS16240	113355..114014	+	660	WP_065680215.1	HAD family phosphatase	-
OCV30_RS16245	114210..114836	+	627	WP_065680214.1	HD domain-containing protein	-
OCV30_RS16250	114879..115376	+	498	WP_065680213.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	105691..106440	749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10524.97 Da
• Isoelectric Point: 9.3651

>T40289 WP_017069754.1 NZ_AP025461:110900-111166 [Vibrio atlanticus]
MTNDRKIVFTDNAWEDYLYWQTQDKKTLKKLNKLIEAAKRTPFEGIGKPEPLVGNLSGFWSRRIDDKNRLVYKADDDNFY
IIACRHHY

Nucleotide

• Length: 267 bp

>T40289 NZ_AP025461:110900-111166 [Vibrio atlanticus]
ATGACGAATGATCGAAAGATTGTATTTACAGATAATGCTTGGGAAGATTACCTATACTGGCAAACCCAAGACAAGAAAAC
GCTCAAGAAACTAAATAAGTTGATTGAAGCTGCCAAAAGAACGCCCTTTGAAGGGATTGGAAAGCCGGAGCCACTAGTCG
GCAACCTCTCTGGCTTTTGGTCAAGACGAATCGATGACAAGAATCGATTAGTGTATAAAGCAGATGACGATAACTTTTAC
ATAATTGCTTGTCGTCACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9534.55 Da
• Isoelectric Point: 4.1353

>AT40289 WP_017061616.1 NZ_AP025461:110653-110910 [Vibrio atlanticus]
MNIVSFTEARNSLKSVLDRVVDDSDVTVITRRDSEDAVVMSLDHFNSMQETLYLMSSPKNAERLAESIAQLEAGNTTVRE
LNNDE

Nucleotide

• Length: 258 bp

>AT40289 NZ_AP025461:110653-110910 [Vibrio atlanticus]
ATGAATATTGTTTCTTTTACTGAGGCCAGAAATAGCCTTAAGTCTGTGCTCGATAGAGTGGTAGACGATTCTGATGTTAC
GGTAATAACCAGACGAGATTCAGAAGATGCCGTGGTAATGTCTCTTGATCATTTTAATTCAATGCAAGAAACCTTGTACC
TAATGAGCTCGCCTAAAAACGCTGAAAGATTGGCTGAATCCATTGCTCAACTCGAAGCCGGAAATACAACCGTTCGAGAA
TTGAATAATGACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1C1X1