Detailed information of TA system TA040288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1276250..1276809
• Replicon: chromosome
• Accession: NZ_AP025459
• Organism: Vibrio artabrorum strain CECT 7226

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCU36_RS19750
• Protein ID: WP_017038685.1
• Coordinates: 1276531..1276809 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A233HRF0
• Locus tag: OCU36_RS19745
• Protein ID: WP_017040620.1
• Coordinates: 1276250..1276534 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU36_RS19725	1272088..1272774	-	687	WP_261840179.1	hypothetical protein	-
OCU36_RS19730	1272852..1272926	-	75	Protein_1109	DUF3265 domain-containing protein	-
OCU36_RS19735	1272905..1273381	-	477	WP_261840180.1	GNAT family N-acetyltransferase	-
OCU36_RS19740	1274195..1274944	+	750	WP_099167608.1	BRO family protein	-
OCU36_RS19745	1276250..1276534	+	285	WP_017040620.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OCU36_RS19750	1276531..1276809	+	279	WP_017038685.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
OCU36_RS19755	1276948..1277703	-	756	WP_261840181.1	restriction endonuclease	-
OCU36_RS19760	1277842..1278267	-	426	WP_170907996.1	GNAT family N-acetyltransferase	-
OCU36_RS19765	1278417..1278824	-	408	WP_261840172.1	VOC family protein	-
OCU36_RS19770	1279041..1279937	+	897	WP_261840182.1	GIY-YIG nuclease family protein	-
OCU36_RS19775	1280418..1281568	+	1151	WP_261837465.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1255189..1319107	63918

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10892.60 Da
• Isoelectric Point: 4.3535

>T40288 WP_017038685.1 NZ_AP025459:1276531-1276809 [Vibrio artabrorum]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDEIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGSIIRIM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T40288 NZ_AP025459:1276531-1276809 [Vibrio artabrorum]
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGTGAGAAGATCTTTGAGTTTCTTTATGACTTTAACCCTGATGCGGC
TGAAAAAACTGATGAAATTATTGAGGCTAAAGTAGAAAACTTACTCGAACAACCATTGATGGGTGTTCAACGGGATGGAA
TTCGAGGACGATTACTCATTATTCCCGAAATCTCAATGATCGTTTCGTACTGGGTAGAAGGTTCAATTATTCGCATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10957.29 Da
• Isoelectric Point: 9.2173

>AT40288 WP_017040620.1 NZ_AP025459:1276250-1276534 [Vibrio artabrorum]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDAWLTEQINLAFEKFDSGKSSFVEHNSAKAR
MAERKAKIRNRGQQ

Nucleotide

• Length: 285 bp

>AT40288 NZ_AP025459:1276250-1276534 [Vibrio artabrorum]
ATGGACACTAGAATTCAATTTCGTGTTGATGACGAAATTAAACGTTTAGCCCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTCAGCGATGCTTGCCGTGAACTTACTGAACAAATGGCTGAGCAACAAAGAAAAACATTATCTCATGACGCTTGGTTAA
CTGAACAAATAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTTCATTTGTTGAACATAACTCTGCTAAAGCACGG
ATGGCTGAACGAAAGGCCAAAATTCGTAATCGAGGCCAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A233HRF0