Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 675922..677750 Replicon chromosome
Accession NZ_AP025458
Organism Vibrio artabrorum strain CECT 7226

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCU36_RS03070 Protein ID WP_261838994.1
Coordinates 676389..677750 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCU36_RS03065 Protein ID WP_261838993.1
Coordinates 675922..676404 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU36_RS03045 671021..671959 - 939 WP_261838989.1 hypothetical protein -
OCU36_RS03050 672242..673954 + 1713 WP_261838990.1 class I SAM-dependent methyltransferase -
OCU36_RS03055 674013..674741 + 729 WP_261838991.1 DUF429 domain-containing protein -
OCU36_RS03060 674840..675649 + 810 WP_261838992.1 M15 family metallopeptidase -
OCU36_RS03065 675922..676404 - 483 WP_261838993.1 helix-turn-helix domain-containing protein Antitoxin
OCU36_RS03070 676389..677750 - 1362 WP_261838994.1 type II toxin-antitoxin system HipA family toxin Toxin
OCU36_RS03075 678003..678296 - 294 Protein_562 IS3 family transposase -
OCU36_RS03080 678885..679412 + 528 WP_261838995.1 DUF2975 domain-containing protein -
OCU36_RS03085 679424..679624 + 201 WP_261838996.1 helix-turn-helix transcriptional regulator -
OCU36_RS03090 679906..680324 + 419 Protein_565 IS5/IS1182 family transposase -
OCU36_RS03095 680518..680997 - 480 WP_261838997.1 MarR family transcriptional regulator -
OCU36_RS03100 681012..681197 - 186 WP_261838998.1 hypothetical protein -
OCU36_RS03105 681342..682235 + 894 WP_261838999.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 662034..722447 60413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51378.28 Da        Isoelectric Point: 5.1384

>T40287 WP_261838994.1 NZ_AP025458:c677750-676389 [Vibrio artabrorum]
MEELTVQAFIRGEWIDIGIISLPKSSQHNFRETELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYKVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRYGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELAEMGVETIA
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRALIEKMTESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKKVLLQELKVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T40287 NZ_AP025458:c677750-676389 [Vibrio artabrorum]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGGGGTGAATGGATAGATATTGGTATCATCTCACTCCCTAAAAGTAGCCA
ACATAATTTCCGAGAAACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCATCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGATCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACAAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCCGGTGATTTCCTCGACTATGCACAACAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATATGGTTTCGATCACGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAGCTGAAATGGGCGTTGAAACGATCGCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTATTGATCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACGA
CCATCCGAGCTCTCATAGAAAAAATGACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGACAACCATGGCAGAAATACTTCATTCTT
AAAGGGTGATGGCGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCCGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTGGGCGGAACTTACGACTTCGTCGGAATAGCAGACACCTTATCTGATCTCGTG
CCAAAGAAAGTGTTATTACAAGAGCTAAAGGTTACGGCAAGTAAATGCATTGACTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTGGAGATGCCAGCCGTTGGACTCAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17610.21 Da        Isoelectric Point: 11.0726

>AT40287 WP_261838993.1 NZ_AP025458:c676404-675922 [Vibrio artabrorum]
MGATMNKPSNKESVQDTVARLRANRNQHQSKTGTNAIHSTKERSQFNTPTRSKASKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGKAQ

Download         Length: 483 bp

>AT40287 NZ_AP025458:c676404-675922 [Vibrio artabrorum]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACGGTCGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGTCCAAGACTGGGACGAATGCAATTCATTCGACCAAAGAACGATCGCAATTTAATACGCCGACTAGATCGAAAG
CCTCAAAAAACGCCAAAGCAGTCAGTGCAGCAGAACGCAAAACCGAGGCAAACAAAATCATTAAACACTTATTACTTGGA
GAGCTAACACAAGGCCAAGCGTTGAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
CGATGTCTCAAGAAAAACACTCTCAGATATAGAGAACGATCGGGGTAGCTACAATACAGAGATTCTCAACAAAGTATTCA
AACCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTATTAATAGATGGTAAGGCTCAG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References