Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 563045..563565 Replicon chromosome
Accession NZ_AP025457
Organism Tsukamurella pulmonis strain TP-B0596

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag TPB0596_RS02610 Protein ID WP_238220031.1
Coordinates 563275..563565 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag TPB0596_RS02605 Protein ID WP_068531205.1
Coordinates 563045..563278 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TPB0596_RS02575 (TPB0596_05270) 558112..558759 + 648 WP_238220939.1 RNA methyltransferase -
TPB0596_RS02580 (TPB0596_05280) 558817..559932 + 1116 WP_068564141.1 glycoside hydrolase family 76 protein -
TPB0596_RS02585 (TPB0596_05290) 559940..560797 + 858 WP_238220028.1 alpha/beta hydrolase -
TPB0596_RS02590 (TPB0596_05300) 560804..561337 - 534 WP_068531197.1 PadR family transcriptional regulator -
TPB0596_RS02595 (TPB0596_05310) 561438..561917 + 480 WP_238220029.1 sigma factor-like helix-turn-helix DNA-binding protein -
TPB0596_RS02600 (TPB0596_05320) 561994..562911 - 918 WP_238220030.1 oxygenase MpaB family protein -
TPB0596_RS02605 (TPB0596_05330) 563045..563278 + 234 WP_068531205.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
TPB0596_RS02610 (TPB0596_05340) 563275..563565 + 291 WP_238220031.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TPB0596_RS02615 (TPB0596_05350) 563572..565218 - 1647 WP_238220032.1 ABC-F family ATP-binding cassette domain-containing protein -
TPB0596_RS02620 (TPB0596_05360) 565220..565855 - 636 WP_170842927.1 DedA family protein -
TPB0596_RS02625 (TPB0596_05370) 565864..566586 - 723 WP_238220033.1 VTT domain-containing protein -
TPB0596_RS02630 (TPB0596_05380) 566605..568476 - 1872 WP_068531214.1 Na+/H+ antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11358.74 Da        Isoelectric Point: 8.8811

>T40283 WP_238220031.1 NZ_AP025457:563275-563565 [Tsukamurella pulmonis]
VTGYRLTPAARRDLSSIWDYTEERWGVRQAETYLVEIRAAIERIAEDPDRGRVCDDVREGYRRYAIGSHVIFYRSRADGV
DLIRVLHQRRDPTRHL

Download         Length: 291 bp

>T40283 NZ_AP025457:563275-563565 [Tsukamurella pulmonis]
GTGACCGGCTATCGGCTCACTCCTGCCGCACGACGCGACCTCTCATCGATCTGGGACTACACGGAGGAGCGCTGGGGCGT
CCGCCAGGCGGAGACTTACCTGGTCGAGATCCGCGCCGCGATCGAACGGATCGCTGAGGATCCCGATCGAGGTCGCGTGT
GCGACGACGTCCGCGAAGGTTACCGACGGTACGCCATCGGGAGCCACGTGATCTTCTACCGGTCGCGTGCCGATGGGGTC
GACCTCATCCGCGTCCTGCATCAACGGAGGGATCCCACGCGGCACCTCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8538.51 Da        Isoelectric Point: 4.4915

>AT40283 WP_068531205.1 NZ_AP025457:563045-563278 [Tsukamurella pulmonis]
MATNTSISLDDHMTEFLAREVATGRYRSASEVVRAGLRMLEDHETRMATLRGALIEGEESGTPEAFDFDEFIAAKKS

Download         Length: 234 bp

>AT40283 NZ_AP025457:563045-563278 [Tsukamurella pulmonis]
ATGGCGACGAACACGTCGATCAGCCTCGACGACCACATGACGGAGTTCCTCGCGCGCGAGGTCGCGACGGGCCGGTACCG
GTCAGCGAGCGAAGTGGTGCGTGCCGGGCTCCGCATGCTCGAGGACCACGAGACCCGGATGGCGACACTTCGCGGCGCCC
TCATCGAGGGCGAGGAGAGCGGAACGCCGGAGGCCTTCGACTTCGACGAATTCATCGCCGCCAAGAAGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References