Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 5173673..5174308 Replicon chromosome
Accession NZ_AP025344
Organism Paenibacillus dendritiformis strain J27TS7

Toxin (Protein)


Gene name pemK Uniprot ID H3SI32
Locus tag L6439_RS22980 Protein ID WP_006677694.1
Coordinates 5173673..5174023 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W4HCL7
Locus tag L6439_RS22985 Protein ID WP_040731899.1
Coordinates 5174027..5174308 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6439_RS22975 5170412..5172883 + 2472 WP_213470716.1 M60 family metallopeptidase -
L6439_RS22980 5173673..5174023 - 351 WP_006677694.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L6439_RS22985 5174027..5174308 - 282 WP_040731899.1 CopG family ribbon-helix-helix protein Antitoxin
L6439_RS22990 5174526..5175752 - 1227 WP_213470714.1 alanine racemase -
L6439_RS22995 5175995..5177113 - 1119 WP_213470712.1 DUF4367 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12843.83 Da        Isoelectric Point: 5.5664

>T40282 WP_006677694.1 NZ_AP025344:c5174023-5173673 [Paenibacillus dendritiformis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMHKVDDGLLISLGLIDF

Download         Length: 351 bp

>T40282 NZ_AP025344:c5174023-5173673 [Paenibacillus dendritiformis]
TTGATTGTAAAGCGCGGCGACGTTTTTTTTGCGGATTTATCGCCCGTCGTAGGTTCAGAGCAAGGAGGAGTGCGTCCCGT
TCTCGTTATCCAGAATGATATCGGGAACCGGTTCAGCCCAACCGTCATCGTGGCGGCAATTACGGCCCAGATTCAGAAGG
CCAAATTGCCGACCCATGTCGAGATTGACGCGAAGACGCATGGGTTCGACCGCGACTCCGTCATTTTGCTGGAACAGATC
CGCACCATCGACAAACAACGGCTCACCGACAAAATAACACACTTAGATGAAGAGACGATGCACAAGGTCGATGACGGGCT
GCTTATCAGCCTCGGATTGATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10735.45 Da        Isoelectric Point: 8.4934

>AT40282 WP_040731899.1 NZ_AP025344:c5174308-5174027 [Paenibacillus dendritiformis]
VANIQNTKRIMISLPDQLLQEVDGIVAMEKSNRSEFIRQAMKLYLQERKKRHIRESMQRGYMEMAKINLTMASEAFYAEV
EADGTLDRLVSGV

Download         Length: 282 bp

>AT40282 NZ_AP025344:c5174308-5174027 [Paenibacillus dendritiformis]
GTGGCTAATATTCAGAACACCAAACGAATTATGATCAGCTTGCCCGACCAACTATTGCAAGAAGTGGACGGTATCGTTGC
TATGGAAAAATCGAATCGAAGCGAGTTCATTCGCCAAGCGATGAAGTTGTATTTGCAAGAGCGCAAGAAGCGTCATATCC
GTGAATCGATGCAGCGCGGCTATATGGAAATGGCCAAGATTAACTTGACGATGGCATCCGAGGCTTTTTACGCAGAAGTC
GAAGCGGATGGCACGCTCGACCGCTTGGTTAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3SI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2W4HCL7

References