Detailed information of TA system TA040279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 2790807..2791726
• Replicon: chromosome
• Accession: NZ_AP025342
• Organism: Bacillus paralicheniformis strain J41TS8

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A6I7TYV7
• Locus tag: L6430_RS14210
• Protein ID: WP_023856735.1
• Coordinates: 2790980..2791726 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: A0A6I7TM13
• Locus tag: L6430_RS14205
• Protein ID: WP_023856734.1
• Coordinates: 2790807..2790980 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6430_RS14180	2786232..2787329	+	1098	WP_025811596.1	mannonate dehydratase	-
L6430_RS14185	2787305..2788153	+	849	WP_023856787.1	SDR family oxidoreductase	-
L6430_RS14190	2788179..2789192	+	1014	WP_065643293.1	zinc-binding alcohol dehydrogenase family protein	-
L6430_RS14195	2789244..2790515	+	1272	WP_026579844.1	MFS transporter	-
L6430_RS14200	2790582..2790713	-	132	WP_023856733.1	hypothetical protein	-
L6430_RS14205	2790807..2790980	-	174	WP_023856734.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
L6430_RS14210	2790980..2791726	-	747	WP_023856735.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
L6430_RS14215	2791836..2792834	-	999	WP_023856736.1	inorganic phosphate transporter	-
L6430_RS14220	2792847..2793464	-	618	WP_023856737.1	DUF47 domain-containing protein	-
L6430_RS14225	2793797..2795554	+	1758	WP_025811589.1	gamma-glutamyltransferase	-
L6430_RS14230	2795689..2796333	+	645	WP_065643294.1	YesL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-57)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29421.87 Da
• Isoelectric Point: 4.6015

>T40279 WP_023856735.1 NZ_AP025342:c2791726-2790980 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Nucleotide

• Length: 747 bp

>T40279 NZ_AP025342:c2791726-2790980 [Bacillus paralicheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTATTGGCGCTGGCTCTGTATGTGGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACGTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCTTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCATATGCAGAAGGGATCGAAAAGCTCATCAAACGATTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGCTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGACGGTGACGACTGA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6897.99 Da
• Isoelectric Point: 10.8356

>AT40279 WP_023856734.1 NZ_AP025342:c2790980-2790807 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Nucleotide

• Length: 174 bp

>AT40279 NZ_AP025342:c2790980-2790807 [Bacillus paralicheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCATGAAAGCGCAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAAGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6I7TYV7

Antitoxin

• AlphaFold DB: A0A6I7TM13