Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1884436..1885072 Replicon chromosome
Accession NZ_AP025342
Organism Bacillus paralicheniformis strain J41TS8

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag L6430_RS09440 Protein ID WP_003179128.1
Coordinates 1884722..1885072 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag L6430_RS09435 Protein ID WP_006638778.1
Coordinates 1884436..1884717 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6430_RS09415 1879546..1881030 + 1485 WP_041817155.1 PH domain-containing protein -
L6430_RS09420 1881027..1881626 - 600 WP_020450255.1 rhomboid family intramembrane serine protease -
L6430_RS09425 1881970..1882929 + 960 WP_165395380.1 outer membrane lipoprotein carrier protein LolA -
L6430_RS09430 1883155..1884324 + 1170 WP_041817156.1 alanine racemase -
L6430_RS09435 1884436..1884717 + 282 WP_006638778.1 hypothetical protein Antitoxin
L6430_RS09440 1884722..1885072 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
L6430_RS09445 1885190..1886017 + 828 WP_065643252.1 RsbT co-antagonist protein RsbRA -
L6430_RS09450 1886021..1886386 + 366 WP_065643251.1 STAS domain-containing protein -
L6430_RS09455 1886389..1886790 + 402 WP_065643250.1 anti-sigma regulatory factor -
L6430_RS09460 1886801..1887808 + 1008 WP_065643249.1 PP2C family protein-serine/threonine phosphatase -
L6430_RS09465 1887866..1888192 + 327 WP_065643248.1 anti-sigma factor antagonist -
L6430_RS09470 1888192..1888674 + 483 WP_065643247.1 anti-sigma B factor RsbW -
L6430_RS09475 1888640..1889431 + 792 WP_065643260.1 RNA polymerase sigma factor SigB -
L6430_RS09480 1889428..1890027 + 600 WP_065643246.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T40278 WP_003179128.1 NZ_AP025342:1884722-1885072 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T40278 NZ_AP025342:1884722-1885072 [Bacillus paralicheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT40278 WP_006638778.1 NZ_AP025342:1884436-1884717 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT40278 NZ_AP025342:1884436-1884717 [Bacillus paralicheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References