40270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 5311305..5311968 Replicon chromosome
Accession NZ_AP025334
Organism Phytobacter diazotrophicus strain TA9734

Toxin (Protein)


Gene name tad Uniprot ID A0A348DL83
Locus tag L6445_RS25490 Protein ID WP_039077908.1
Coordinates 5311305..5311649 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A348DL84
Locus tag L6445_RS25495 Protein ID WP_071194355.1
Coordinates 5311651..5311968 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6445_RS25470 (5306982) 5306982..5308388 - 1407 WP_039077905.1 replicative DNA helicase -
L6445_RS25475 (5308447) 5308447..5309430 + 984 WP_039077906.1 quinone oxidoreductase -
L6445_RS25480 (5309719) 5309719..5309961 - 243 WP_039077907.1 envelope stress response protein PspG -
L6445_RS25485 (5310114) 5310114..5311112 - 999 WP_039077935.1 tRNA dihydrouridine(20/20a) synthase DusA -
L6445_RS25490 (5311305) 5311305..5311649 + 345 WP_039077908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6445_RS25495 (5311651) 5311651..5311968 + 318 WP_071194355.1 helix-turn-helix transcriptional regulator Antitoxin
L6445_RS25500 (5312010) 5312010..5313326 - 1317 WP_039077910.1 conjugal transfer protein TraF -
L6445_RS25505 (5313599) 5313599..5314114 + 516 WP_039077912.1 zinc uptake transcriptional repressor Zur -
L6445_RS25510 (5314222) 5314222..5314431 - 210 WP_039077936.1 CsbD family protein -
L6445_RS25515 (5314529) 5314529..5314717 + 189 WP_071194358.1 hypothetical protein -
L6445_RS25520 (5314692) 5314692..5315306 - 615 WP_039077914.1 transcriptional repressor LexA -
L6445_RS25525 (5315415) 5315415..5315783 - 369 WP_079497650.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12655.46 Da        Isoelectric Point: 9.5820

>T40270 WP_039077908.1 NZ_AP025334:5311305-5311649 [Phytobacter diazotrophicus]
MKPLYWVGSSKKDLQSLPEDVQDVFGYALHLAQDGGKHPQAKPLKGFGGAGVLEVVEDYCTDTYRAVYTLKFRQAVYVLH
AFQKKSSSGMQTPKSDIEKIRERLKAAEAHARGA

Download         Length: 345 bp

>T40270 NZ_AP025334:5311305-5311649 [Phytobacter diazotrophicus]
ATGAAGCCACTGTATTGGGTGGGGAGCAGCAAAAAAGATCTTCAGTCTCTGCCGGAGGATGTTCAGGATGTTTTTGGTTA
TGCGTTGCATCTCGCACAAGACGGAGGTAAGCATCCCCAGGCAAAACCGTTAAAAGGATTTGGGGGCGCAGGTGTGCTGG
AGGTGGTCGAAGACTATTGCACCGATACTTATCGCGCGGTTTATACCCTGAAATTCAGACAGGCGGTCTATGTGCTACAT
GCATTTCAGAAGAAGTCGTCATCCGGTATGCAAACCCCCAAATCTGATATAGAAAAAATTCGAGAACGTCTTAAGGCAGC
AGAAGCCCATGCCAGAGGAGCATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11644.64 Da        Isoelectric Point: 11.1929

>AT40270 WP_071194355.1 NZ_AP025334:5311651-5311968 [Phytobacter diazotrophicus]
MSQNIDISSGNVYADIGLDNADEMQVKAQLATTIGNIIKSRRLTQVEAAKLLGMTQPRLSNMLRGQFRGISEVKMLECLT
RLGRDVQIVVGRPRRTPGRMKVVFA

Download         Length: 318 bp

>AT40270 NZ_AP025334:5311651-5311968 [Phytobacter diazotrophicus]
ATGAGCCAGAATATCGATATCAGCAGCGGCAATGTTTATGCCGACATTGGACTGGACAATGCGGATGAAATGCAGGTTAA
AGCGCAGCTTGCTACCACCATTGGCAATATCATTAAAAGTCGTCGTCTTACTCAGGTGGAGGCGGCAAAGTTATTGGGGA
TGACACAGCCCAGGCTATCAAATATGCTGCGCGGCCAATTTCGCGGCATAAGTGAAGTAAAAATGCTTGAATGTCTGACA
CGCTTAGGGCGCGATGTTCAAATTGTGGTTGGGCGCCCGCGCCGTACCCCGGGACGTATGAAGGTGGTTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DL83

Antitoxin

Source ID Structure
AlphaFold DB A0A348DL84

References