Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2835002..2835924 Replicon chromosome
Accession NZ_AP025334
Organism Phytobacter diazotrophicus strain TA9734

Toxin (Protein)


Gene name - Uniprot ID A0A348DED3
Locus tag L6445_RS13650 Protein ID WP_039079059.1
Coordinates 2835448..2835924 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A348DED2
Locus tag L6445_RS13645 Protein ID WP_071194172.1
Coordinates 2835002..2835448 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6445_RS13635 (2830675) 2830675..2833722 - 3048 WP_125124690.1 formate dehydrogenase-N subunit alpha -
L6445_RS13640 (2834055) 2834055..2834936 + 882 WP_125124691.1 aromatic amino acid DMT transporter YddG -
L6445_RS13645 (2835002) 2835002..2835448 + 447 WP_071194172.1 DUF2384 domain-containing protein Antitoxin
L6445_RS13650 (2835448) 2835448..2835924 + 477 WP_039079059.1 RES family NAD+ phosphorylase Toxin
L6445_RS13655 (2835908) 2835908..2837410 - 1503 WP_125124692.1 MFS transporter -
L6445_RS13660 (2837523) 2837523..2838113 + 591 WP_125124693.1 TetR family transcriptional regulator -
L6445_RS13665 (2838095) 2838095..2838937 - 843 WP_125124694.1 N-hydroxyarylamine O-acetyltransferase -
L6445_RS13670 (2839013) 2839013..2840668 - 1656 WP_125124695.1 iron ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-150)

Antitoxin

(28-90)


Sequences


Toxin        


Download         Length: 159 a.a.        Molecular weight: 17725.30 Da        Isoelectric Point: 5.2290

>T40260 WP_039079059.1 NZ_AP025334:2835448-2835924 [Phytobacter diazotrophicus]
METVTFWRLVKERYALTAFDGYGARTFGGRWNSPGHECVYLGESKALCVLETLVHLEIEDIAQGYCFLTLDVPRNLIATL
DLTALPEDWKADPPPVSTQHIGDEWLASKQNGLVLRVPSTITGEWNALFNPEHPQAAKVLKSVKSEPFMLDPRLSRPC

Download         Length: 477 bp

>T40260 NZ_AP025334:2835448-2835924 [Phytobacter diazotrophicus]
ATGGAAACTGTCACCTTCTGGCGTCTGGTCAAAGAACGCTATGCGCTGACCGCCTTCGACGGTTACGGCGCGCGAACCTT
TGGCGGACGCTGGAATTCACCGGGGCATGAATGCGTCTACCTGGGTGAATCAAAAGCTCTCTGCGTGCTGGAAACACTGG
TACATCTTGAGATTGAAGATATCGCCCAGGGCTACTGTTTCTTAACCCTCGATGTACCACGTAATCTTATCGCGACGCTG
GATTTGACCGCCCTGCCCGAAGACTGGAAAGCTGACCCGCCGCCTGTTTCCACGCAACACATCGGCGATGAGTGGCTGGC
ATCAAAGCAAAACGGGCTGGTACTGCGCGTCCCCAGTACCATCACCGGCGAATGGAACGCGCTGTTTAACCCCGAACACC
CACAGGCGGCGAAAGTCCTCAAAAGCGTAAAGTCCGAACCCTTTATGCTGGATCCCCGTCTTAGCCGTCCTTGCTAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 15690.07 Da        Isoelectric Point: 8.9810

>AT40260 WP_071194172.1 NZ_AP025334:2835002-2835448 [Phytobacter diazotrophicus]
MQLYTPGVRAIPHDLLSILGLPATAIAAHDSINAGLSAGVLRDIAGAVSLDEITLCRMAGIDRNTYSRRLNSAEKRFSPE
QSARVYTLARVISAARELFEGDSERMATWLNKPAKGLGGKKPAELLSTPAGAEAVLTLIGRLEHGVIG

Download         Length: 447 bp

>AT40260 NZ_AP025334:2835002-2835448 [Phytobacter diazotrophicus]
ATGCAACTCTATACACCGGGCGTACGCGCGATCCCGCACGACCTGCTCAGCATCCTGGGGCTGCCCGCCACGGCGATTGC
CGCTCATGACAGCATTAATGCCGGTCTGAGTGCAGGTGTGTTGCGTGATATCGCTGGCGCCGTCTCTCTTGATGAAATCA
CGCTGTGCCGAATGGCTGGCATTGATCGTAATACCTATAGCCGCAGGCTTAACAGCGCGGAAAAACGCTTTTCACCAGAA
CAGAGTGCGCGCGTCTACACGCTGGCACGAGTGATCAGCGCCGCTCGTGAGTTATTTGAAGGTGACAGCGAGCGTATGGC
CACCTGGCTCAATAAACCCGCGAAAGGCCTTGGCGGTAAAAAACCCGCAGAGCTTCTCTCGACACCCGCCGGTGCGGAAG
CGGTACTGACATTGATTGGTCGCCTTGAGCATGGTGTGATCGGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A348DED3


Antitoxin

Source ID Structure
AlphaFold DB A0A348DED2

References