Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2786970..2787613 Replicon chromosome
Accession NZ_AP025334
Organism Phytobacter diazotrophicus strain TA9734

Toxin (Protein)


Gene name vagD Uniprot ID A0A348DE83
Locus tag L6445_RS13400 Protein ID WP_071194208.1
Coordinates 2787197..2787613 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A348DE82
Locus tag L6445_RS13395 Protein ID WP_071194209.1
Coordinates 2786970..2787200 (+) Length 77 a.a.

Genomic Context

L6445_RS13375L6445_RS13380L6445_RS13385L6445_RS13395L6445_RS13400L6445_RS13410L6445_RS13415L6445_RS13420L6445_RS13390L6445_RS13405
Location: 2783132..2783509 (378 bp)
Type: Others
Protein ID: WP_108701294.1
Location: 2783580..2784533 (954 bp)
Type: Others
Protein ID: WP_039079008.1
Location: 2784585..2785349 (765 bp)
Type: Others
Protein ID: WP_039079009.1
Location: 2786970..2787200 (231 bp)
Type: Antitoxin
Protein ID: WP_071194209.1
Location: 2787197..2787613 (417 bp)
Type: Toxin
Protein ID: WP_071194208.1
Location: 2788568..2789566 (999 bp)
Type: Others
Protein ID: WP_039079015.1
Location: 2789566..2790603 (1038 bp)
Type: Others
Protein ID: WP_125124673.1
Location: 2790603..2791364 (762 bp)
Type: Others
Protein ID: WP_071194204.1
Location: 2785426..2786712 (1287 bp)
Type: Others
Protein ID: WP_125124672.1
Location: 2787876..2788283 (408 bp)
Type: Others
Protein ID: WP_125125677.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
L6445_RS13375 (2783132)2783132..2783509+378WP_108701294.1VOC family protein-
L6445_RS13380 (2783580)2783580..2784533+954WP_039079008.12-hydroxyacid dehydrogenase-
L6445_RS13385 (2784585)2784585..2785349+765WP_039079009.1SDR family oxidoreductase-
L6445_RS13390 (2785426)2785426..2786712-1287WP_125124672.1MFS transporter-
L6445_RS13395 (2786970)2786970..2787200+231WP_071194209.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
L6445_RS13400 (2787197)2787197..2787613+417WP_071194208.1PIN domain-containing proteinToxin
L6445_RS13405 (2787876)2787876..2788283-408WP_125125677.1nuclear transport factor 2 family protein-
L6445_RS13410 (2788568)2788568..2789566+999WP_039079015.1ABC transporter substrate-binding protein-
L6445_RS13415 (2789566)2789566..2790603+1038WP_125124673.1iron chelate uptake ABC transporter family permease subunit-
L6445_RS13420 (2790603)2790603..2791364+762WP_071194204.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15050.57 Da        Isoelectric Point: 9.2345

>T40259 WP_071194208.1 NZ_AP025334:2787197-2787613 [Phytobacter diazotrophicus]
MKKTFMLDTNICSFIMREHPESVIKRLEQAVLRNNRIVVSAITYAEMRFGAIGKKASPHHAKLVDAFCARLDAVLAWDRA
AVDATTQIKLALALAGTPIGPNDTAIAGHAIAAGVVLVTNNTREFERVPGLILEDWAK

Download         Length: 417 bp

>T40259 NZ_AP025334:2787197-2787613 [Phytobacter diazotrophicus]
ATGAAGAAAACCTTTATGCTCGACACTAATATTTGCTCATTCATCATGCGCGAGCATCCGGAAAGCGTTATTAAGCGTCT
GGAGCAGGCAGTGTTGCGCAACAATCGAATCGTAGTATCGGCTATCACCTATGCGGAAATGCGCTTCGGCGCGATCGGTA
AAAAGGCGTCGCCGCATCATGCGAAGCTGGTTGATGCGTTCTGTGCTCGCCTTGATGCCGTGCTCGCCTGGGACCGGGCG
GCAGTGGATGCCACTACGCAAATAAAGCTTGCGCTGGCGTTGGCTGGTACGCCGATTGGTCCGAACGATACCGCGATTGC
CGGGCATGCTATTGCCGCTGGCGTCGTGCTGGTAACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTGATTCTGG
AAGACTGGGCAAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8783.91 Da        Isoelectric Point: 4.3654

>AT40259 WP_071194209.1 NZ_AP025334:2786970-2787200 [Phytobacter diazotrophicus]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIIREGDCIILRPVRPTWSSFAQLEKADPDFMAEREDVVSDEGRFDL

Download         Length: 231 bp

>AT40259 NZ_AP025334:2786970-2787200 [Phytobacter diazotrophicus]
ATGCGAACCGTATCCATCTTCAAAAACGGCAACAATCGTGCCATCCGTCTGCCTCGCGATCTGGATTTCGAAGGAGTGAG
CGAACTGGAGATCATCAGGGAAGGGGACTGCATCATCCTGCGCCCGGTGCGACCGACGTGGAGTTCTTTCGCGCAATTAG
AAAAAGCCGACCCGGATTTTATGGCAGAACGTGAAGATGTGGTCAGTGATGAGGGACGCTTTGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A348DE83

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DE82

References