Detailed information of TA system TA040250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1491689..1492171
• Replicon: chromosome
• Accession: NZ_AP025332
• Organism: Streptococcus ruminantium strain GUT-184

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L6419_RS07145
• Protein ID: WP_155962643.1
• Coordinates: 1491689..1491949 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L6419_RS07150
• Protein ID: WP_024532383.1
• Coordinates: 1491950..1492171 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6419_RS07125 (GUT184_13680)	1487489..1487707	+	219	WP_024532387.1	glutaredoxin-like protein NrdH	-
L6419_RS07130 (GUT184_13690)	1487750..1489909	+	2160	WP_237375238.1	class 1b ribonucleoside-diphosphate reductase subunit alpha	-
L6419_RS07135 (GUT184_13700)	1490119..1491081	+	963	WP_024532385.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
L6419_RS07140 (GUT184_13710)	1491283..1491672	-	390	WP_237375239.1	hypothetical protein	-
L6419_RS07145 (GUT184_13720)	1491689..1491949	-	261	WP_155962643.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6419_RS07150 (GUT184_13730)	1491950..1492171	-	222	WP_024532383.1	DUF6290 family protein	Antitoxin
L6419_RS07155 (GUT184_13740)	1492371..1492715	-	345	WP_227985764.1	minor capsid protein	-
L6419_RS07160 (GUT184_13750)	1493143..1495131	+	1989	WP_237375240.1	GAG-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1487489..1492700	5211

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10264.78 Da
• Isoelectric Point: 9.6925

>T40250 WP_155962643.1 NZ_AP025332:c1491949-1491689 [Streptococcus ruminantium]
MYHVEYSKKAQKQIRKLDKSIQRLLFAWVDKHLDGTDTPRTNGKGLTGNHANEWRYRIGDYRLICEIQEDKMVILALEFG
HRKDIY

Nucleotide

• Length: 261 bp

>T40250 NZ_AP025332:c1491949-1491689 [Streptococcus ruminantium]
ATGTATCATGTAGAGTATTCAAAAAAGGCTCAAAAGCAGATCAGAAAGCTGGATAAATCTATCCAAAGGCTACTTTTTGC
TTGGGTAGATAAGCATTTAGACGGTACAGACACCCCACGAACTAACGGCAAGGGATTGACAGGAAACCACGCCAATGAAT
GGCGTTATCGTATCGGTGATTATAGACTGATATGCGAAATTCAAGAGGATAAGATGGTTATTCTAGCTCTTGAGTTTGGG
CATAGGAAAGATATTTACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.55 Da
• Isoelectric Point: 4.6128

>AT40250 WP_024532383.1 NZ_AP025332:c1492171-1491950 [Streptococcus ruminantium]
MSTVTIRLNQEEETFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYKQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT40250 NZ_AP025332:c1492171-1491950 [Streptococcus ruminantium]
ATGAGTACAGTAACTATCAGATTAAATCAAGAAGAAGAAACATTTTTCAAAAGCTATGCTCAATTAACAGGGCAAAGTCT
TTCAAGTCTTTTCAAGAAAGCTCTTGAGCGTGATATTGAAGATGAGTATGATTTGAAAATTTATAAACAAGCCTATGCTG
AATACAAAGCAGACCCAGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTGGGCTTGTAA