Detailed information of TA system TA040247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 729446..729928
• Replicon: chromosome
• Accession: NZ_AP025331
• Organism: Streptococcus ruminantium strain GUT-183

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SUT_RS03585
• Protein ID: WP_155962643.1
• Coordinates: 729668..729928 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SUT_RS03580
• Protein ID: WP_024532383.1
• Coordinates: 729446..729667 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUT_RS03570 (GUT183_06650)	726471..728495	-	2025	WP_237373551.1	GAG-binding domain-containing protein	-
SUT_RS03575 (GUT183_06660)	728902..729246	+	345	WP_272877510.1	minor capsid protein	-
SUT_RS03580 (GUT183_06670)	729446..729667	+	222	WP_024532383.1	DUF6290 family protein	Antitoxin
SUT_RS03585 (GUT183_06680)	729668..729928	+	261	WP_155962643.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SUT_RS03590 (GUT183_06690)	729903..730223	+	321	WP_237373553.1	hypothetical protein	-
SUT_RS03595 (GUT183_06700)	730496..731458	-	963	WP_024532385.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
SUT_RS03600 (GUT183_06710)	731668..733827	-	2160	WP_155964515.1	class 1b ribonucleoside-diphosphate reductase subunit alpha	-
SUT_RS03605 (GUT183_06720)	733870..734088	-	219	WP_024532387.1	glutaredoxin-like protein NrdH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	728917..734088	5171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10264.78 Da
• Isoelectric Point: 9.6925

>T40247 WP_155962643.1 NZ_AP025331:729668-729928 [Streptococcus ruminantium]
MYHVEYSKKAQKQIRKLDKSIQRLLFAWVDKHLDGTDTPRTNGKGLTGNHANEWRYRIGDYRLICEIQEDKMVILALEFG
HRKDIY

Nucleotide

• Length: 261 bp

>T40247 NZ_AP025331:729668-729928 [Streptococcus ruminantium]
ATGTATCATGTAGAGTATTCAAAAAAGGCTCAAAAGCAGATCAGAAAGCTGGATAAATCTATCCAAAGGCTACTTTTTGC
TTGGGTAGATAAGCATTTAGACGGTACAGACACCCCACGAACTAACGGCAAGGGATTGACAGGAAACCACGCCAATGAAT
GGCGTTATCGTATCGGTGATTATAGACTGATATGCGAAATTCAAGAGGATAAGATGGTTATTCTAGCTCTTGAGTTTGGG
CATAGGAAAGATATTTACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.55 Da
• Isoelectric Point: 4.6128

>AT40247 WP_024532383.1 NZ_AP025331:729446-729667 [Streptococcus ruminantium]
MSTVTIRLNQEEETFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYKQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT40247 NZ_AP025331:729446-729667 [Streptococcus ruminantium]
ATGAGTACAGTAACTATCAGATTAAATCAAGAAGAAGAAACATTTTTCAAAAGCTATGCTCAATTAACAGGGCAAAGTCT
TTCAAGTCTTTTCAAGAAAGCTCTTGAGCGTGATATTGAAGATGAGTATGATTTGAAAATTTATAAACAAGCCTATGCTG
AATACAAAGCAGACCCAGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTGGGCTTGTAA