Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 1676927..1677416 Replicon chromosome
Accession NZ_AP025285
Organism Leptogranulimonas caecicola strain TOC12

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OR601_RS07380 Protein ID WP_265592391.1
Coordinates 1677198..1677416 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag OR601_RS07375 Protein ID WP_265591561.1
Coordinates 1676927..1677163 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OR601_RS07340 (ATTO_14600) 1672670..1672936 - 267 WP_265591554.1 hypothetical protein -
OR601_RS07345 (ATTO_14620) 1674737..1674886 + 150 WP_265591555.1 hypothetical protein -
OR601_RS07350 (ATTO_14630) 1675160..1675465 + 306 WP_265591556.1 hypothetical protein -
OR601_RS07355 (ATTO_14640) 1675559..1675891 + 333 WP_265591557.1 hypothetical protein -
OR601_RS07360 (ATTO_14650) 1675941..1676120 + 180 WP_265591558.1 hypothetical protein -
OR601_RS07365 (ATTO_14660) 1676216..1676485 + 270 WP_265591559.1 hypothetical protein -
OR601_RS07370 (ATTO_14670) 1676538..1676858 + 321 WP_265591560.1 hypothetical protein -
OR601_RS07375 (ATTO_14680) 1676927..1677163 + 237 WP_265591561.1 ribbon-helix-helix domain-containing protein Antitoxin
OR601_RS07380 (ATTO_14690) 1677198..1677416 + 219 WP_265592391.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OR601_RS07385 (ATTO_14710) 1678082..1678690 + 609 WP_265591562.1 hypothetical protein -
OR601_RS07390 (ATTO_14720) 1678988..1679437 + 450 WP_265591563.1 hypothetical protein -
OR601_RS07395 (ATTO_14730) 1679460..1679924 + 465 WP_265591564.1 hypothetical protein -
OR601_RS07400 (ATTO_14740) 1679926..1680255 + 330 WP_265591565.1 hypothetical protein -
OR601_RS07405 (ATTO_14750) 1680495..1680731 + 237 WP_265591566.1 ribbon-helix-helix domain-containing protein -
OR601_RS07410 (ATTO_14770) 1680974..1682062 - 1089 WP_265591567.1 SPFH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-69)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8336.60 Da        Isoelectric Point: 9.6259

>T40246 WP_265592391.1 NZ_AP025285:1677198-1677416 [Leptogranulimonas caecicola]
MDKQTSKLILDRMDEIAALNDPRSRGKALEGTLTGFWRYRINGYRVICSIEDSELVILAVSVDHRSKVYKRH

Download         Length: 219 bp

>T40246 NZ_AP025285:1677198-1677416 [Leptogranulimonas caecicola]
ATGGATAAGCAGACATCCAAGCTCATTCTCGACCGCATGGATGAGATCGCAGCACTTAACGACCCAAGAAGCCGAGGCAA
GGCACTAGAGGGAACCCTGACGGGGTTTTGGCGTTATCGTATAAACGGTTATCGTGTGATATGTTCCATCGAAGATAGCG
AGTTGGTCATTCTCGCGGTATCCGTCGACCATCGGAGCAAAGTTTACAAACGTCACTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8826.98 Da        Isoelectric Point: 5.0939

>AT40246 WP_265591561.1 NZ_AP025285:1676927-1677163 [Leptogranulimonas caecicola]
MATIATTMRVPDDVAARYDRLAKATGRTKTFYMTKALRDAIDSMEYEYGILQELEDYRSGKTVAYSSEEMRARCGLDG

Download         Length: 237 bp

>AT40246 NZ_AP025285:1676927-1677163 [Leptogranulimonas caecicola]
ATGGCAACCATCGCAACGACAATGAGGGTACCTGATGATGTCGCCGCTCGATACGATCGACTGGCTAAAGCCACTGGACG
TACAAAAACCTTTTACATGACAAAAGCTCTCAGGGATGCTATCGACAGCATGGAATACGAATACGGAATCCTTCAAGAGC
TTGAGGACTACCGTTCAGGTAAAACAGTTGCCTACAGCTCAGAAGAAATGAGGGCGCGCTGTGGCCTGGATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References