Detailed information of TA system TA040238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2245735..2246245
• Replicon: chromosome
• Accession: NZ_AP025281
• Organism: Aliamphritea hakodatensis strain PT3

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PCI15_RS10270
• Protein ID: WP_271274239.1
• Coordinates: 2245735..2245998 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: PCI15_RS10275
• Protein ID: WP_271274240.1
• Coordinates: 2245991..2246245 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCI15_RS10250	2241343..2242119	-	777	WP_271274235.1	SDR family NAD(P)-dependent oxidoreductase	-
PCI15_RS10255	2242154..2242768	+	615	WP_271274236.1	DUF4440 domain-containing protein	-
PCI15_RS10260	2242856..2244202	-	1347	WP_271274237.1	aspartate aminotransferase family protein	-
PCI15_RS10265	2244430..2245713	+	1284	WP_271274238.1	tyrosine--tRNA ligase	-
PCI15_RS10270	2245735..2245998	-	264	WP_271274239.1	Txe/YoeB family addiction module toxin	Toxin
PCI15_RS10275	2245991..2246245	-	255	WP_271274240.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PCI15_RS10280	2246362..2247078	-	717	WP_271274241.1	LuxR C-terminal-related transcriptional regulator	-
PCI15_RS10285	2247281..2247730	+	450	WP_271274242.1	ester cyclase	-
PCI15_RS10290	2247764..2248252	+	489	WP_271274243.1	MEKHLA domain-containing protein	-
PCI15_RS10295	2248286..2249776	-	1491	WP_271274244.1	tripartite tricarboxylate transporter permease	-
PCI15_RS10300	2249791..2250402	-	612	WP_271274245.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10551.18 Da
• Isoelectric Point: 9.9165

>T40238 WP_271274239.1 NZ_AP025281:c2245998-2245735 [Aliamphritea hakodatensis]
MTDRLLSWTDESWSDYLYWQTQDKKTLKRINKLIRDVKRAPFEGIGKPEPLKENLSGFWSRRIDETNRLVYVIEKKAIVI
ISCRYHY

Nucleotide

• Length: 264 bp

>T40238 NZ_AP025281:c2245998-2245735 [Aliamphritea hakodatensis]
ATGACTGACCGCCTGCTCAGCTGGACTGATGAATCATGGAGCGATTATCTGTACTGGCAGACGCAGGATAAGAAAACCCT
GAAACGTATCAACAAACTCATTCGCGATGTAAAACGCGCTCCTTTTGAAGGGATCGGAAAGCCGGAACCGCTTAAGGAAA
ACCTTTCCGGCTTCTGGTCCAGACGAATCGATGAAACCAACAGGCTCGTTTACGTCATTGAAAAGAAAGCCATCGTGATC
ATTTCATGCCGGTATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9526.59 Da
• Isoelectric Point: 5.0733

>AT40238 WP_271274240.1 NZ_AP025281:c2246245-2245991 [Aliamphritea hakodatensis]
MRVITFTEARNNLKNVLDEVVNDADTTVITRRDSEDAVVMSLDHYNSLLETVHLLRSPANAAHLSRSIEQYKQGKTSPRE
LTDD

Nucleotide

• Length: 255 bp

>AT40238 NZ_AP025281:c2246245-2245991 [Aliamphritea hakodatensis]
ATGCGAGTCATTACATTTACCGAAGCCCGGAACAATCTGAAAAACGTGCTGGATGAAGTGGTCAATGATGCAGACACAAC
GGTCATCACCCGAAGAGATTCTGAAGATGCTGTTGTCATGTCTCTGGATCATTACAACAGTCTTCTTGAAACTGTTCATC
TGTTACGTTCTCCGGCCAACGCTGCCCATCTGAGCCGCTCCATTGAACAGTACAAACAGGGAAAAACCAGTCCGCGGGAA
CTGACCGATGACTGA