40231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2717454..2718846 Replicon chromosome
Accession NZ_AP025273
Organism Pseudomonas alcaligenes strain MRCP2

Toxin (Protein)


Gene name - Uniprot ID U2Z838
Locus tag L6431_RS12915 Protein ID WP_021701965.1
Coordinates 2717454..2718023 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag L6431_RS12920 Protein ID WP_237044214.1
Coordinates 2718016..2718846 (+) Length 277 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6431_RS12905 2712910..2713608 - 699 WP_021701967.1 pirin-like bicupin family protein -
L6431_RS12910 2713818..2717288 - 3471 WP_237044213.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
L6431_RS12915 2717454..2718023 + 570 WP_021701965.1 GNAT family protein Toxin
L6431_RS12920 2718016..2718846 + 831 WP_237044214.1 AraC family transcriptional regulator Antitoxin
L6431_RS12925 2718909..2719619 + 711 WP_142136920.1 AzlC family ABC transporter permease -
L6431_RS12930 2719619..2719948 + 330 WP_237044215.1 AzlD domain-containing protein -
L6431_RS12935 2720135..2722033 + 1899 WP_237044216.1 MFS transporter -
L6431_RS12940 2722086..2722400 - 315 WP_061904959.1 quaternary ammonium compound efflux SMR transporter SugE -
L6431_RS12945 2722565..2723485 - 921 WP_237044217.1 recombination-associated protein RdgC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(194-271)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21212.24 Da        Isoelectric Point: 9.5851

>T40231 WP_021701965.1 NZ_AP025273:2717454-2718023 [Pseudomonas alcaligenes]
MFKPQPVALQQGALRLDPLTEADLPGLLQLAEANRASQQFMSGTTRPDWYRSALAEQREGREVVFAIRLAGELVGTTSFF
DFNPVLPAAEIGATWLDVGQHGTGLNRMIKYLMLRHAFEEWQLVRVQLKTAASNLRAQRAIEKLGAQREGLLRNHRRLAD
GRLDHTVMYSITDSEWPQVKAGLESRFGA

Download         Length: 570 bp

>T40231 NZ_AP025273:2717454-2718023 [Pseudomonas alcaligenes]
ATGTTCAAGCCCCAACCCGTCGCCCTGCAGCAGGGCGCCCTGCGCCTCGACCCGCTGACCGAGGCCGACCTGCCGGGCCT
GCTGCAGCTGGCCGAGGCCAACCGCGCATCGCAGCAGTTCATGAGTGGCACGACCCGCCCGGACTGGTATCGCAGCGCCC
TGGCCGAGCAGCGCGAGGGCCGCGAGGTGGTGTTCGCCATCCGCCTGGCCGGCGAGCTGGTCGGCACCACCAGCTTCTTC
GACTTCAATCCGGTGCTGCCGGCCGCCGAGATCGGCGCCACCTGGCTCGACGTGGGCCAGCACGGCACCGGCCTCAACCG
CATGATCAAGTACCTGATGCTGCGCCATGCCTTCGAGGAGTGGCAGCTGGTGCGCGTGCAGCTGAAGACCGCCGCCAGCA
ACCTGCGCGCGCAGCGTGCCATCGAGAAGCTCGGCGCCCAGCGTGAGGGTTTGCTGCGCAACCACCGGCGCCTGGCCGAC
GGGCGCCTCGACCACACCGTGATGTACAGCATCACCGACAGCGAGTGGCCGCAGGTCAAGGCTGGCCTGGAGTCGCGCTT
CGGTGCCTGA

Antitoxin


Download         Length: 277 a.a.        Molecular weight: 30910.10 Da        Isoelectric Point: 8.0317

>AT40231 WP_237044214.1 NZ_AP025273:2718016-2718846 [Pseudomonas alcaligenes]
VPDAEQARFSSVAELGGLELLSARFIEHSFAPHVHDSYAIAVLEEGAERYRYRGAEHLAAAGSFALLNPDEVHTGSRASE
QGWRYRVFYPQPQQFRELLAELELPHSSAPMFDGSVHADTDLVAALLQLHRQLEQPQAPTLWRQTLWREVMLRLLQRHAR
IPQAREPGAEPRAVALAKELLAARLGEPPSLEELATLVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLRSGCAPL
QVALQLGFADQSHLNRQFKQSYGVSPGEYRRACAGG

Download         Length: 831 bp

>AT40231 NZ_AP025273:2718016-2718846 [Pseudomonas alcaligenes]
GTGCCTGACGCCGAGCAGGCGCGCTTCAGCTCGGTGGCCGAGCTGGGCGGCCTGGAGCTGTTGTCCGCGCGCTTCATCGA
GCACAGCTTCGCCCCGCATGTACACGACAGCTACGCCATCGCCGTGCTGGAGGAGGGGGCCGAGCGTTATCGCTATCGTG
GCGCCGAGCACCTGGCGGCGGCCGGCAGCTTTGCCCTGCTCAACCCCGACGAGGTGCATACCGGCTCCAGAGCCAGCGAG
CAGGGTTGGCGCTATCGGGTGTTCTATCCGCAGCCGCAGCAGTTCCGCGAGCTGCTCGCCGAGCTGGAACTGCCGCATTC
CAGCGCGCCGATGTTCGATGGCAGCGTGCATGCCGATACCGATCTGGTCGCGGCACTGCTGCAGCTGCACCGGCAGCTGG
AGCAGCCGCAGGCGCCCACCCTGTGGCGCCAGACGCTGTGGCGCGAGGTGATGCTGCGCCTGCTGCAGCGCCATGCGCGT
ATTCCGCAGGCGCGTGAGCCCGGCGCCGAGCCACGGGCCGTGGCCCTGGCCAAGGAGTTGCTGGCCGCGCGCCTGGGCGA
GCCCCCTTCACTGGAGGAACTGGCGACGCTGGTCAATCTGTCGCCGTTCCACTTCGCCCGGGTGTTCCGTCGCGCCACCG
GCCTGCCGCCGCATGCCTGGCTCAAGCAGCGCCGCCTGGAGCAGGCGCGGGCGTTGCTGCGCTCCGGCTGCGCGCCGCTG
CAGGTGGCGCTGCAGCTGGGCTTCGCCGACCAGAGCCACCTGAACCGGCAGTTCAAGCAGAGCTACGGCGTCAGCCCCGG
CGAGTATCGCCGCGCCTGCGCGGGCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2Z838

Antitoxin

Source ID Structure

References