40230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2707447..2708664 Replicon chromosome
Accession NZ_AP025273
Organism Pseudomonas alcaligenes strain MRCP2

Toxin (Protein)


Gene name - Uniprot ID U3BAP8
Locus tag L6431_RS12880 Protein ID WP_021701972.1
Coordinates 2707912..2708664 (+) Length 251 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A142IU32
Locus tag L6431_RS12875 Protein ID WP_061904973.1
Coordinates 2707447..2707818 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6431_RS12845 2703140..2703862 + 723 WP_237044208.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
L6431_RS12850 2703864..2705231 - 1368 WP_237044209.1 4Fe-4S binding protein -
L6431_RS12855 2705228..2706061 - 834 WP_237044210.1 FTR1 family protein -
L6431_RS12860 2706071..2706391 - 321 WP_021701976.1 cupredoxin domain-containing protein -
L6431_RS12865 2706424..2706960 - 537 WP_237044211.1 iron transporter -
L6431_RS12870 2707133..2707354 + 222 WP_169919403.1 hypothetical protein -
L6431_RS12875 2707447..2707818 + 372 WP_061904973.1 DUF2384 domain-containing protein Antitoxin
L6431_RS12880 2707912..2708664 + 753 WP_021701972.1 RES family NAD+ phosphorylase Toxin
L6431_RS12885 2708665..2709129 - 465 WP_142136914.1 copper chaperone PCu(A)C -
L6431_RS12890 2709628..2710041 + 414 WP_021701970.1 SEL1-like repeat protein -
L6431_RS12895 2710222..2711583 + 1362 WP_169919799.1 DNA recombination protein RmuC -
L6431_RS12900 2711585..2712841 - 1257 WP_237044212.1 MgtC/SapB family protein -
L6431_RS12905 2712910..2713608 - 699 WP_021701967.1 pirin-like bicupin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(72-121)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 28303.31 Da        Isoelectric Point: 7.0308

>T40230 WP_021701972.1 NZ_AP025273:2707912-2708664 [Pseudomonas alcaligenes]
MDIWQACAGVEQIIPLRGRLVRLVENQGQVATLQLVDTLEEQALLEQLLESSKPPLPPGDEPLHYLLRTPFRYPPLRWGS
RFGRRHEPSLFYAACRLETAMAETAFYRFVLWYGMVEPPPSGRILSEHSSFEARYQVQRGVRLQLPPFDGHRALLTHRSD
YRATHSLGSAMREAGVEAFEYPSARCPQGGNNVALYAPTAFSEKRPRNLQPWLCETTAGYVAFKNAQAPEPPRLFALELY
LEDGVLPQPA

Download         Length: 753 bp

>T40230 NZ_AP025273:2707912-2708664 [Pseudomonas alcaligenes]
ATGGATATCTGGCAGGCCTGTGCCGGCGTAGAGCAGATCATTCCCCTGCGCGGCCGCCTGGTGCGCCTGGTCGAGAACCA
GGGCCAGGTGGCGACCCTGCAGCTGGTGGATACGCTGGAGGAGCAGGCGCTGCTCGAACAGTTGCTGGAGAGCAGCAAGC
CGCCGCTGCCGCCCGGTGACGAGCCGCTGCACTATCTGTTGCGCACGCCGTTTCGCTACCCGCCGCTGCGCTGGGGCTCG
CGTTTCGGCCGGCGCCATGAGCCGAGCCTGTTCTACGCCGCCTGCCGGCTGGAGACGGCGATGGCCGAGACGGCCTTCTA
TCGTTTCGTGCTGTGGTACGGCATGGTCGAGCCGCCGCCGAGCGGGCGCATCCTTTCCGAGCATTCGTCTTTCGAGGCGC
GCTACCAGGTGCAGCGCGGGGTGCGCCTGCAGCTGCCGCCATTCGACGGCCATCGCGCGCTGCTGACCCATCGCAGTGAC
TATCGCGCCACCCACAGCCTGGGTAGTGCGATGCGCGAAGCGGGGGTGGAAGCCTTCGAGTATCCCTCGGCACGCTGCCC
GCAGGGGGGCAACAACGTTGCCCTGTATGCACCGACGGCGTTCAGCGAGAAGCGGCCGCGCAACCTGCAGCCCTGGCTGT
GCGAAACCACCGCAGGCTACGTGGCCTTCAAGAACGCCCAGGCGCCCGAGCCGCCGCGCCTGTTTGCCCTCGAACTCTAT
CTCGAGGATGGCGTGCTGCCGCAGCCAGCCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13364.54 Da        Isoelectric Point: 10.8344

>AT40230 WP_061904973.1 NZ_AP025273:2707447-2707818 [Pseudomonas alcaligenes]
MSALSKPGVDAGAVLLKALLNSREQLGLTQQELAAIVGVNRSAISRWSDSGGLRPESKTGELALLLIRAYRALFALFGGN
LQDMRHFLRTENRHLAGVPLQQMGQVQGLVRVVEYLDAIRGKV

Download         Length: 372 bp

>AT40230 NZ_AP025273:2707447-2707818 [Pseudomonas alcaligenes]
ATGAGCGCACTCAGCAAGCCAGGTGTCGATGCCGGCGCCGTCCTGCTCAAGGCCCTGCTCAACAGCCGTGAGCAGCTGGG
CCTGACCCAGCAGGAGCTGGCGGCGATAGTCGGCGTCAACCGTTCCGCCATCAGTCGCTGGAGCGACAGCGGCGGCCTGC
GTCCGGAGAGCAAGACCGGTGAGCTGGCCTTGCTGCTGATCCGCGCCTATCGCGCCCTGTTCGCCCTGTTCGGCGGCAAT
CTGCAGGACATGCGGCATTTCCTGCGCACTGAGAATCGCCATCTGGCCGGTGTGCCCTTGCAGCAGATGGGGCAGGTACA
GGGGCTGGTGCGGGTGGTCGAGTACCTGGACGCCATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U3BAP8

Antitoxin

Source ID Structure
AlphaFold DB A0A142IU32

References