Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1884790..1885483 Replicon chromosome
Accession NZ_AP025273
Organism Pseudomonas alcaligenes strain MRCP2

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag L6431_RS08920 Protein ID WP_003151133.1
Coordinates 1884790..1885167 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag L6431_RS08925 Protein ID WP_001172026.1
Coordinates 1885148..1885483 (+) Length 112 a.a.

Genomic Context

L6431_RS08920L6431_RS08925L6431_RS08930L6431_RS08935L6431_RS08940L6431_RS08945L6431_RS08950L6431_RS08955L6431_RS08960L6431_RS08905L6431_RS08910L6431_RS08915
Location: 1884790..1885167 (378 bp)
Type: Toxin
Protein ID: WP_003151133.1
Location: 1885148..1885483 (336 bp)
Type: Antitoxin
Protein ID: WP_001172026.1
Location: 1885498..1885803 (306 bp)
Type: Others
Protein ID: WP_223198361.1
Location: 1885856..1886182 (327 bp)
Type: Others
Protein ID: WP_000091614.1
Location: 1886179..1886559 (381 bp)
Type: Others
Protein ID: WP_001054412.1
Location: 1886716..1887018 (303 bp)
Type: Others
Protein ID: WP_237046571.1
Location: 1887110..1887979 (870 bp)
Type: Others
Protein ID: WP_223198360.1
Location: 1888389..1888628 (240 bp)
Type: Others
Protein ID: WP_034011918.1
Location: 1888628..1889038 (411 bp)
Type: Others
Protein ID: WP_034011919.1
Location: 1879901..1880746 (846 bp)
Type: Others
Protein ID: WP_003464995.1
Location: 1880983..1884012 (3030 bp)
Type: Others
Protein ID: WP_024015041.1
Location: 1883996..1884598 (603 bp)
Type: Others
Protein ID: WP_010465829.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
L6431_RS089051879901..1880746-846WP_003464995.1AraC family transcriptional regulator-
L6431_RS089101880983..1884012-3030WP_024015041.1Tn3 family transposase-
L6431_RS089151883996..1884598-603WP_010465829.1recombinase family protein-
L6431_RS089201884790..1885167+378WP_003151133.1type II toxin-antitoxin system RelE/ParE family toxinToxin
L6431_RS089251885148..1885483+336WP_001172026.1helix-turn-helix transcriptional regulatorAntitoxin
L6431_RS089301885498..1885803+306WP_223198361.1transposase-
L6431_RS089351885856..1886182+327WP_000091614.1hypothetical protein-
L6431_RS089401886179..1886559+381WP_001054412.1hypothetical protein-
L6431_RS089451886716..1887018+303WP_237046571.1DUF3391 domain-containing protein-
L6431_RS089501887110..1887979+870WP_223198360.1HD-GYP domain-containing protein-
L6431_RS089551888389..1888628+240WP_034011918.1ribbon-helix-helix domain-containing protein-
L6431_RS089601888628..1889038+411WP_034011919.1putative toxin-antitoxin system toxin component, PIN family-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T40229 WP_003151133.1 NZ_AP025273:1884790-1885167 [Pseudomonas alcaligenes]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T40229 NZ_AP025273:1884790-1885167 [Pseudomonas alcaligenes]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT40229 WP_001172026.1 NZ_AP025273:1885148-1885483 [Pseudomonas alcaligenes]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT40229 NZ_AP025273:1885148-1885483 [Pseudomonas alcaligenes]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A024ELN5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A024EKI7

References