Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 268421..269105 Replicon chromosome
Accession NZ_AP025258
Organism Paraburkholderia terrae strain KU-15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PTKU15_RS31050 Protein ID WP_091783245.1
Coordinates 268421..268606 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PTKU15_RS31055 Protein ID WP_007583253.1
Coordinates 268686..269105 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTKU15_RS31030 (PTKU15_61370) 263878..264855 + 978 WP_248557402.1 M14 family metallopeptidase -
PTKU15_RS31035 (PTKU15_61380) 264896..265240 + 345 WP_042306072.1 cupin domain-containing protein -
PTKU15_RS31040 (PTKU15_61390) 265491..266501 + 1011 WP_042306073.1 ABC transporter substrate-binding protein -
PTKU15_RS31045 (PTKU15_61400) 266614..268299 + 1686 WP_248557403.1 GMC family oxidoreductase N-terminal domain-containing protein -
PTKU15_RS31050 (PTKU15_61410) 268421..268606 + 186 WP_091783245.1 type II toxin-antitoxin system HicA family toxin Toxin
PTKU15_RS31055 (PTKU15_61420) 268686..269105 + 420 WP_007583253.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PTKU15_RS31060 (PTKU15_61430) 269165..270592 - 1428 WP_248557404.1 aldehyde dehydrogenase family protein -
PTKU15_RS31065 (PTKU15_61440) 270613..271410 - 798 WP_180725691.1 ABC transporter permease -
PTKU15_RS31070 (PTKU15_61450) 271407..272318 - 912 WP_007583258.1 ABC transporter permease -
PTKU15_RS31075 (PTKU15_61460) 272315..273646 - 1332 WP_248557405.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-68)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7063.14 Da        Isoelectric Point: 11.1658

>T40199 WP_091783245.1 NZ_AP025258:268421-268606 [Paraburkholderia terrae]
MKYSEFRKWLKQQGATFEKHRSGSSHYRVTLNGRTTIFPDHGAKEMGKGLVEAIRKQLGIR

Download         Length: 186 bp

>T40199 NZ_AP025258:268421-268606 [Paraburkholderia terrae]
ATGAAATACAGCGAGTTCAGGAAGTGGCTGAAACAGCAAGGTGCGACGTTCGAAAAGCACCGAAGCGGCTCAAGTCACTA
CCGGGTGACGCTCAATGGCAGGACCACCATCTTCCCCGATCACGGTGCGAAGGAAATGGGTAAAGGACTGGTGGAAGCCA
TCAGGAAGCAGCTCGGTATCAGGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15280.65 Da        Isoelectric Point: 4.9658

>AT40199 WP_007583253.1 NZ_AP025258:268686-269105 [Paraburkholderia terrae]
MLSYPISLTPDDNGTLLVTFPDVPEAITVGDDEEDAKVQALDALEAAFEIYFAEKRSIPMPSKAKRGQSVVTLPALVTAK
VLLADEMLRQNVRKAELARRLSVNQVQVDRLLNFGHSSKIEMVESAFAVLGKRLDVRAV

Download         Length: 420 bp

>AT40199 NZ_AP025258:268686-269105 [Paraburkholderia terrae]
ATGCTCAGCTACCCGATCAGCCTGACACCCGACGACAACGGAACGCTGCTCGTCACGTTTCCTGATGTTCCGGAAGCCAT
CACCGTCGGCGACGACGAAGAGGACGCGAAAGTGCAAGCGCTGGATGCGCTCGAGGCCGCGTTCGAAATCTACTTCGCGG
AGAAGCGAAGCATCCCGATGCCTTCGAAGGCCAAACGTGGGCAATCCGTCGTTACGTTGCCGGCGCTTGTGACCGCGAAA
GTGTTGCTCGCGGATGAAATGCTCCGCCAGAACGTGCGAAAGGCTGAACTCGCGCGACGGCTCAGCGTCAATCAGGTGCA
GGTCGATCGACTTCTAAACTTCGGCCATTCATCGAAGATCGAGATGGTCGAGTCGGCGTTTGCGGTATTGGGTAAGCGCC
TTGATGTTCGCGCGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References