Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1633181..1633826 Replicon chromosome
Accession NZ_AP025245
Organism Acidianus sp. HS-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HS5_RS08680 Protein ID WP_236750977.1
Coordinates 1633437..1633826 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HS5_RS08675 Protein ID WP_236750975.1
Coordinates 1633181..1633450 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS5_RS08650 (HS5_17480) 1628964..1630004 - 1041 WP_236750969.1 phospholipase D-like domain-containing protein -
HS5_RS08655 (HS5_17490) 1630085..1630297 + 213 WP_236750970.1 VapB-type antitoxin -
HS5_RS08660 (HS5_17500) 1630290..1630682 + 393 WP_236750971.1 PIN domain-containing protein -
HS5_RS08665 (HS5_17510) 1630688..1631869 - 1182 WP_236750972.1 MFS transporter -
HS5_RS08670 (HS5_17520) 1632580..1632981 + 402 WP_236750973.1 type II toxin-antitoxin system VapC family toxin -
HS5_RS08675 (HS5_17530) 1633181..1633450 + 270 WP_236750975.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HS5_RS08680 (HS5_17540) 1633437..1633826 + 390 WP_236750977.1 type II toxin-antitoxin system VapC family toxin Toxin
HS5_RS08685 (HS5_17550) 1633844..1634467 - 624 WP_236750979.1 type 1 glutamine amidotransferase -
HS5_RS08690 (HS5_17560) 1634651..1635832 + 1182 WP_236750981.1 carboxypeptidase CpsA -
HS5_RS08695 (HS5_17570) 1635819..1637057 - 1239 WP_236750983.1 amidohydrolase family protein -
HS5_RS08700 (HS5_17580) 1637076..1638254 - 1179 WP_236750985.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(4-46)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15162.57 Da        Isoelectric Point: 4.4109

>T40175 WP_236750977.1 NZ_AP025245:1633437-1633826 [Acidianus sp. HS-5]
MIFLDANFIIYLNLGVKEIENFYIKVLQEDQLAIDSLVIDEVIYISKKKYNVNFNDTINFLDEIVLPNSLILPIRKEDYE
TAKSIMLNYNLKPSDAFHVAVMLNNSINKIISEDKDFDRVKEIERIWLT

Download         Length: 390 bp

>T40175 NZ_AP025245:1633437-1633826 [Acidianus sp. HS-5]
ATGATATTTCTTGACGCAAACTTTATCATTTACTTAAATCTAGGGGTAAAAGAAATAGAAAATTTTTATATTAAAGTATT
ACAAGAAGATCAACTAGCCATAGATTCATTAGTTATAGATGAAGTAATTTACATTTCAAAGAAAAAATATAACGTAAACT
TTAACGATACAATAAATTTTCTGGATGAGATTGTCTTACCCAATTCTTTAATCCTTCCAATACGGAAGGAAGATTACGAA
ACCGCAAAAAGCATAATGTTAAATTATAATCTAAAACCGTCAGACGCGTTTCACGTTGCAGTAATGCTAAATAATTCAAT
TAATAAAATTATAAGTGAGGATAAGGATTTTGATAGAGTAAAAGAAATTGAAAGAATTTGGTTGACATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10107.68 Da        Isoelectric Point: 5.7528

>AT40175 WP_236750975.1 NZ_AP025245:1633181-1633450 [Acidianus sp. HS-5]
MTLRIEVGKKGYIIIPKDIRDLLGIKEGDRLILSVYDGKIILEPERKINVSEILKRLEEHHARISSYAKSAKLGDLANSS
LEEEFDDIS

Download         Length: 270 bp

>AT40175 NZ_AP025245:1633181-1633450 [Acidianus sp. HS-5]
TTGACTCTAAGAATTGAAGTTGGAAAGAAGGGTTACATAATTATTCCTAAGGACATCAGAGACCTCCTAGGTATAAAAGA
AGGTGACAGGCTTATCCTGAGCGTTTATGATGGTAAAATTATTCTTGAGCCTGAAAGAAAAATTAACGTCAGCGAAATTT
TAAAAAGACTAGAGGAACATCATGCTAGAATTTCATCTTATGCAAAAAGTGCAAAATTAGGAGACCTAGCAAATTCAAGC
CTTGAAGAGGAGTTCGATGATATTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References