Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2328177..2329150 Replicon chromosome
Accession NZ_AP025226
Organism Saccharolobus caldissimus strain JCM 32116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SACC_RS12780 Protein ID WP_229569876.1
Coordinates 2328539..2329150 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SACC_RS12775 Protein ID WP_229569875.1
Coordinates 2328177..2328521 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACC_RS12735 (SACC_25370) 2323382..2323620 - 239 Protein_2513 IS5/IS1182 family transposase -
SACC_RS12740 2323785..2324027 + 243 WP_229572628.1 AAA family ATPase -
SACC_RS12745 (SACC_25380) 2324616..2325086 - 471 WP_229569864.1 DsrE/DsrF/DrsH-like family protein -
SACC_RS12750 (SACC_25390) 2325312..2325926 + 615 WP_229569865.1 carbonic anhydrase -
SACC_RS12755 (SACC_25400) 2325943..2326701 - 759 WP_229569866.1 hypothetical protein -
SACC_RS12760 (SACC_25410) 2326994..2327383 + 390 WP_229569872.1 CBS domain-containing protein -
SACC_RS12765 (SACC_25420) 2327519..2327794 + 276 WP_229569873.1 hypothetical protein -
SACC_RS12770 (SACC_25430) 2327867..2328100 + 234 WP_229569874.1 C2H2-type zinc finger protein -
SACC_RS12775 (SACC_25440) 2328177..2328521 + 345 WP_229569875.1 DUF488 domain-containing protein Antitoxin
SACC_RS12780 (SACC_25450) 2328539..2329150 + 612 WP_229569876.1 helix-turn-helix domain-containing protein Toxin
SACC_RS12785 (SACC_25460) 2329347..2330525 + 1179 WP_229569877.1 amidohydrolase family protein -
SACC_RS12790 (SACC_25470) 2330634..2332454 + 1821 WP_229569878.1 4Fe-4S binding protein -
SACC_RS12795 (SACC_25480) 2332505..2333692 - 1188 WP_229569885.1 FtsX-like permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 23087.00 Da        Isoelectric Point: 8.9733

>T40171 WP_229569876.1 NZ_AP025226:2328539-2329150 [Saccharolobus caldissimus]
VYRSPFEVTVLIEDHPCEVMKIISLTGLKASVENVKLGEQTTDHIVSFEKEIEKSEVLKLKSNSVKVLRLSESKVWVRTN
GCAVCRILYTSDVVVEKIKVIKERTLLYTLLVPNNSSFKEFLTKLSKEGVKVTVLNVSEISGAELTERQMEILQLAYKLG
YFNDDRGITLSQLADKLGISPPTLEEILRRALRKVVKYYLDKH

Download         Length: 612 bp

>T40171 NZ_AP025226:2328539-2329150 [Saccharolobus caldissimus]
GTGTATAGATCTCCCTTTGAAGTAACAGTACTAATAGAGGATCATCCTTGTGAAGTAATGAAAATAATATCATTAACGGG
ACTTAAAGCAAGTGTAGAAAACGTTAAGTTAGGAGAACAAACTACTGACCATATAGTTAGTTTCGAAAAGGAGATAGAGA
AGAGTGAAGTTCTAAAATTAAAGTCAAATAGTGTTAAAGTACTAAGACTCAGTGAAAGTAAAGTATGGGTGAGAACTAAT
GGATGTGCTGTATGCAGGATACTTTATACTTCTGATGTAGTTGTAGAGAAAATTAAAGTAATAAAAGAAAGGACTTTACT
TTATACTTTACTTGTGCCTAATAACTCATCGTTTAAGGAATTTTTAACTAAATTGTCGAAAGAAGGAGTAAAGGTAACAG
TTTTAAACGTCTCAGAGATATCTGGTGCGGAACTTACTGAGAGACAGATGGAAATACTGCAATTAGCCTATAAGTTAGGT
TATTTTAATGATGATAGAGGTATTACTTTATCTCAATTAGCAGATAAATTGGGAATAAGTCCGCCAACTCTGGAAGAAAT
ATTAAGGAGAGCTCTCAGAAAAGTTGTTAAGTATTATTTGGATAAGCATTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13684.97 Da        Isoelectric Point: 9.9999

>AT40171 WP_229569875.1 NZ_AP025226:2328177-2328521 [Saccharolobus caldissimus]
MIKVKRVYDPLEKDDGIRILVDRLWPRGVKKDQVDVWLKDIAPSDELRKWYNHDPNKWEEFKRKYFEELSRNPKVEILLQ
LIKKGNNITLLYASKSPYNNAVALKEYLEKVLKV

Download         Length: 345 bp

>AT40171 NZ_AP025226:2328177-2328521 [Saccharolobus caldissimus]
ATGATAAAAGTTAAGAGAGTTTACGATCCTTTAGAAAAGGATGATGGAATTAGGATTTTAGTGGATAGATTATGGCCTAG
AGGTGTTAAGAAGGATCAAGTAGACGTTTGGCTTAAGGACATAGCACCTAGTGATGAACTAAGGAAATGGTATAATCACG
ATCCTAACAAATGGGAGGAGTTTAAAAGGAAGTACTTTGAGGAACTCAGTAGAAATCCTAAGGTTGAGATACTCTTACAG
TTAATTAAAAAGGGGAATAATATAACCTTACTTTATGCCTCAAAGTCTCCATATAATAATGCAGTGGCATTAAAAGAGTA
TTTAGAGAAGGTATTAAAGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References