Detailed information of TA system TA040170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1541032..1541623
• Replicon: chromosome
• Accession: NZ_AP025226
• Organism: Saccharolobus caldissimus strain JCM 32116

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SACC_RS08550
• Protein ID: WP_229569050.1
• Coordinates: 1541255..1541623 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SACC_RS08545
• Protein ID: WP_229569049.1
• Coordinates: 1541032..1541274 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SACC_RS08520 (SACC_16770)	1536532..1538205	+	1674	WP_229572499.1	urease subunit alpha	-
SACC_RS08525 (SACC_16780)	1538293..1538694	+	402	WP_229569045.1	hypothetical protein	-
SACC_RS08530 (SACC_16790)	1538681..1539277	+	597	WP_229569046.1	urease accessory UreF family protein	-
SACC_RS08535 (SACC_16800)	1539274..1539903	+	630	WP_229569047.1	urease accessory protein UreG	-
SACC_RS08540 (SACC_16810)	1539881..1540489	+	609	WP_229569048.1	urease accessory protein UreD	-
SACC_RS08545 (SACC_16820)	1541032..1541274	+	243	WP_229569049.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SACC_RS08550 (SACC_16830)	1541255..1541623	+	369	WP_229569050.1	PIN domain-containing protein	Toxin
SACC_RS08555 (SACC_16840)	1542049..1542408	+	360	WP_229569051.1	hypothetical protein	-
SACC_RS08560 (SACC_16850)	1542405..1542959	+	555	WP_229572588.1	hypothetical protein	-
SACC_RS08565 (SACC_16860)	1543102..1543317	+	216	WP_229569052.1	hypothetical protein	-
SACC_RS08570 (SACC_16870)	1543353..1543652	-	300	WP_229569053.1	hypothetical protein	-
SACC_RS08575 (SACC_16880)	1543642..1544100	-	459	WP_229569054.1	hypothetical protein	-
SACC_RS08580 (SACC_16890)	1544348..1545718	+	1371	WP_229569055.1	cytochrome ubiquinol oxidase subunit I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• SpoVT-AbrB domain (4-46)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14299.55 Da
• Isoelectric Point: 4.9617

>T40170 WP_229569050.1 NZ_AP025226:1541255-1541623 [Saccharolobus caldissimus]
MEEVVVDTNFVIAVIFEDHIFHKLAIEDWGKIHKAYLPIIAVSELAYFLIKNRFNLDDVLENVLSDPKIEVVENTLEDVY
FAIRNSPKSYDDFNDYMIISLAKRLGLKILTYDDKMKRKQKS

Nucleotide

• Length: 369 bp

>T40170 NZ_AP025226:1541255-1541623 [Saccharolobus caldissimus]
TTGGAAGAAGTAGTAGTTGATACCAATTTTGTGATTGCTGTAATTTTTGAGGATCATATTTTTCATAAATTAGCAATAGA
GGATTGGGGAAAAATACACAAAGCTTATTTGCCTATAATCGCCGTTTCTGAACTTGCATACTTCTTAATAAAAAATAGAT
TTAATTTAGATGATGTTTTAGAAAATGTTTTATCTGATCCGAAGATAGAAGTAGTCGAAAATACTTTAGAGGATGTATAT
TTTGCAATAAGAAATTCGCCTAAATCCTATGATGATTTTAACGATTATATGATAATTTCTCTAGCTAAAAGATTGGGACT
TAAAATACTTACTTATGACGATAAAATGAAAAGAAAACAAAAAAGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9014.38 Da
• Isoelectric Point: 10.0013

>AT40170 WP_229569049.1 NZ_AP025226:1541032-1541274 [Saccharolobus caldissimus]
VEEVKVTRNYQITIPSTIRAKLNIRVGDKLLVYVENNKIIIEKKSGNITSLNLRLGRKFTDEDINKIIAEAGEEIGRSSS

Nucleotide

• Length: 243 bp

>AT40170 NZ_AP025226:1541032-1541274 [Saccharolobus caldissimus]
GTGGAAGAAGTTAAAGTTACGAGAAACTATCAGATAACTATCCCCTCCACGATTAGAGCTAAACTAAATATTCGAGTTGG
TGACAAACTATTAGTTTATGTTGAAAATAATAAAATAATCATAGAAAAGAAAAGCGGAAATATCACATCGTTAAACCTTA
GGTTAGGTAGAAAGTTTACCGATGAAGATATTAACAAAATCATAGCCGAGGCCGGAGAGGAAATTGGAAGAAGTAGTAGT
TGA