Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-CcdA |
| Location | 1430577..1431183 | Replicon | chromosome |
| Accession | NZ_AP025226 | ||
| Organism | Saccharolobus caldissimus strain JCM 32116 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | SACC_RS07980 | Protein ID | WP_229572407.1 |
| Coordinates | 1430791..1431183 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | SACC_RS07975 | Protein ID | WP_229572406.1 |
| Coordinates | 1430577..1430801 (+) | Length | 75 a.a. |
Genomic Context
Location: 1426137..1426493 (357 bp)
Type: Others
Protein ID: WP_229572581.1
Type: Others
Protein ID: WP_229572581.1
Location: 1428360..1429325 (966 bp)
Type: Others
Protein ID: WP_229572404.1
Type: Others
Protein ID: WP_229572404.1
Location: 1429315..1429632 (318 bp)
Type: Others
Protein ID: WP_229572405.1
Type: Others
Protein ID: WP_229572405.1
Location: 1429927..1430087 (161 bp)
Type: Others
Protein ID: Protein_1555
Type: Others
Protein ID: Protein_1555
Location: 1430577..1430801 (225 bp)
Type: Antitoxin
Protein ID: WP_229572406.1
Type: Antitoxin
Protein ID: WP_229572406.1
Location: 1430791..1431183 (393 bp)
Type: Toxin
Protein ID: WP_229572407.1
Type: Toxin
Protein ID: WP_229572407.1
Location: 1426640..1427662 (1023 bp)
Type: Others
Protein ID: WP_229569857.1
Type: Others
Protein ID: WP_229569857.1
Location: 1431222..1433555 (2334 bp)
Type: Others
Protein ID: WP_229572408.1
Type: Others
Protein ID: WP_229572408.1
Location: 1433562..1434572 (1011 bp)
Type: Others
Protein ID: WP_229572409.1
Type: Others
Protein ID: WP_229572409.1
Location: 1434569..1435525 (957 bp)
Type: Others
Protein ID: WP_229572410.1
Type: Others
Protein ID: WP_229572410.1
Location: 1435530..1435940 (411 bp)
Type: Others
Protein ID: WP_229572411.1
Type: Others
Protein ID: WP_229572411.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SACC_RS07950 (SACC_15670) | 1426137..1426493 | + | 357 | WP_229572581.1 | ADP-ribosylglycohydrolase family protein | - |
| SACC_RS07955 (SACC_15680) | 1426640..1427662 | - | 1023 | WP_229569857.1 | DUF4322 domain-containing protein | - |
| SACC_RS07960 (SACC_15690) | 1428360..1429325 | + | 966 | WP_229572404.1 | CRISPR system ring nuclease | - |
| SACC_RS07965 (SACC_15700) | 1429315..1429632 | + | 318 | WP_229572405.1 | clan AA aspartic protease | - |
| SACC_RS07970 | 1429927..1430087 | + | 161 | Protein_1555 | ISH3 family transposase | - |
| SACC_RS07975 (SACC_15710) | 1430577..1430801 | + | 225 | WP_229572406.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| SACC_RS07980 (SACC_15720) | 1430791..1431183 | + | 393 | WP_229572407.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SACC_RS07985 (SACC_15730) | 1431222..1433555 | - | 2334 | WP_229572408.1 | hydrolase | - |
| SACC_RS07990 (SACC_15740) | 1433562..1434572 | - | 1011 | WP_229572409.1 | type III-A CRISPR-associated RAMP protein Csm5 | - |
| SACC_RS07995 (SACC_15750) | 1434569..1435525 | - | 957 | WP_229572410.1 | type III-A CRISPR-associated RAMP protein Csm3 | - |
| SACC_RS08000 (SACC_15760) | 1435530..1435940 | - | 411 | WP_229572411.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1425030..1426115 | 1085 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 15136.78 Da Isoelectric Point: 8.2995
>T40169 WP_229572407.1 NZ_AP025226:1430791-1431183 [Saccharolobus caldissimus]
MKDKEFLFDASALYSLLDYVDKVDIKKIHILTLTFYEVGNVIWKEYYIHNKVKDPITLSRLFHKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
MKDKEFLFDASALYSLLDYVDKVDIKKIHILTLTFYEVGNVIWKEYYIHNKVKDPITLSRLFHKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
Download Length: 393 bp
>T40169 NZ_AP025226:1430791-1431183 [Saccharolobus caldissimus]
ATGAAAGATAAGGAATTCCTATTTGATGCCTCAGCTTTATATTCGCTTTTAGATTACGTGGATAAGGTAGATATTAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAATAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCCATAAATTAATGCGAAAATTTAACGTAGTAGAGGATCCACCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAATGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA
ATGAAAGATAAGGAATTCCTATTTGATGCCTCAGCTTTATATTCGCTTTTAGATTACGTGGATAAGGTAGATATTAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAATAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCCATAAATTAATGCGAAAATTTAACGTAGTAGAGGATCCACCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAATGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8787.18 Da Isoelectric Point: 5.0355
>AT40169 WP_229572406.1 NZ_AP025226:1430577-1430801 [Saccharolobus caldissimus]
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIREKEKEELKDMAMKIKELMKDVSEDDWVRAVRESRDER
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIREKEKEELKDMAMKIKELMKDVSEDDWVRAVRESRDER
Download Length: 225 bp
>AT40169 NZ_AP025226:1430577-1430801 [Saccharolobus caldissimus]
ATGTCAGACGTAATAAGCGTAAGGGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAGGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGGCTATGAAAATTAAGGAAC
TAATGAAGGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
ATGTCAGACGTAATAAGCGTAAGGGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAGGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGGCTATGAAAATTAAGGAAC
TAATGAAGGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA