Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1430577..1431183 Replicon chromosome
Accession NZ_AP025226
Organism Saccharolobus caldissimus strain JCM 32116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SACC_RS07980 Protein ID WP_229572407.1
Coordinates 1430791..1431183 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SACC_RS07975 Protein ID WP_229572406.1
Coordinates 1430577..1430801 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACC_RS07950 (SACC_15670) 1426137..1426493 + 357 WP_229572581.1 ADP-ribosylglycohydrolase family protein -
SACC_RS07955 (SACC_15680) 1426640..1427662 - 1023 WP_229569857.1 DUF4322 domain-containing protein -
SACC_RS07960 (SACC_15690) 1428360..1429325 + 966 WP_229572404.1 CRISPR system ring nuclease -
SACC_RS07965 (SACC_15700) 1429315..1429632 + 318 WP_229572405.1 clan AA aspartic protease -
SACC_RS07970 1429927..1430087 + 161 Protein_1555 ISH3 family transposase -
SACC_RS07975 (SACC_15710) 1430577..1430801 + 225 WP_229572406.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SACC_RS07980 (SACC_15720) 1430791..1431183 + 393 WP_229572407.1 type II toxin-antitoxin system VapC family toxin Toxin
SACC_RS07985 (SACC_15730) 1431222..1433555 - 2334 WP_229572408.1 hydrolase -
SACC_RS07990 (SACC_15740) 1433562..1434572 - 1011 WP_229572409.1 type III-A CRISPR-associated RAMP protein Csm5 -
SACC_RS07995 (SACC_15750) 1434569..1435525 - 957 WP_229572410.1 type III-A CRISPR-associated RAMP protein Csm3 -
SACC_RS08000 (SACC_15760) 1435530..1435940 - 411 WP_229572411.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1425030..1426115 1085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(9-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15136.78 Da        Isoelectric Point: 8.2995

>T40169 WP_229572407.1 NZ_AP025226:1430791-1431183 [Saccharolobus caldissimus]
MKDKEFLFDASALYSLLDYVDKVDIKKIHILTLTFYEVGNVIWKEYYIHNKVKDPITLSRLFHKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T40169 NZ_AP025226:1430791-1431183 [Saccharolobus caldissimus]
ATGAAAGATAAGGAATTCCTATTTGATGCCTCAGCTTTATATTCGCTTTTAGATTACGTGGATAAGGTAGATATTAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAATAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCCATAAATTAATGCGAAAATTTAACGTAGTAGAGGATCCACCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAATGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8787.18 Da        Isoelectric Point: 5.0355

>AT40169 WP_229572406.1 NZ_AP025226:1430577-1430801 [Saccharolobus caldissimus]
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIREKEKEELKDMAMKIKELMKDVSEDDWVRAVRESRDER

Download         Length: 225 bp

>AT40169 NZ_AP025226:1430577-1430801 [Saccharolobus caldissimus]
ATGTCAGACGTAATAAGCGTAAGGGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAGGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGGCTATGAAAATTAAGGAAC
TAATGAAGGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References