40167

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1228862..1229465 Replicon chromosome
Accession NZ_AP025226
Organism Saccharolobus caldissimus strain JCM 32116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SACC_RS07055 Protein ID WP_229572254.1
Coordinates 1228862..1229251 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SACC_RS07060 Protein ID WP_229572255.1
Coordinates 1229238..1229465 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACC_RS07015 (SACC_13820) 1224292..1224483 + 192 WP_229572246.1 hypothetical protein -
SACC_RS07020 (SACC_13830) 1224994..1226163 - 1170 WP_229572247.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
SACC_RS07025 (SACC_13840) 1226287..1226475 + 189 WP_229572248.1 hypothetical protein -
SACC_RS07030 (SACC_13850) 1226728..1226946 + 219 WP_229572249.1 hypothetical protein -
SACC_RS16670 (SACC_13860) 1226954..1227088 + 135 WP_282099535.1 hypothetical protein -
SACC_RS07035 (SACC_13870) 1227081..1227545 + 465 WP_229572250.1 HAD-IA family hydrolase -
SACC_RS07040 (SACC_13880) 1227834..1228169 - 336 WP_229572251.1 nucleotidyltransferase domain-containing protein -
SACC_RS07045 (SACC_13890) 1228154..1228354 - 201 WP_229572252.1 HEPN domain-containing protein -
SACC_RS07050 (SACC_13900) 1228519..1228776 - 258 WP_229572253.1 HEPN domain-containing protein -
SACC_RS07055 (SACC_13910) 1228862..1229251 - 390 WP_229572254.1 PIN domain-containing protein Toxin
SACC_RS07060 (SACC_13920) 1229238..1229465 - 228 WP_229572255.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SACC_RS07065 (SACC_13930) 1229734..1230114 + 381 WP_229572256.1 PaREP1 family protein -
SACC_RS07070 (SACC_13940) 1230080..1230442 + 363 WP_229572257.1 PaREP1 family protein -
SACC_RS07075 (SACC_13950) 1230729..1232153 + 1425 WP_229572258.1 phenylacetate--CoA ligase family protein -
SACC_RS07080 (SACC_13960) 1232156..1233451 - 1296 WP_229572259.1 hydroxyacid-oxoacid transhydrogenase -
SACC_RS07085 (SACC_13970) 1233456..1234271 - 816 WP_229572260.1 N-acyl homoserine lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(3-47)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14848.46 Da        Isoelectric Point: 4.7430

>T40167 WP_229572254.1 NZ_AP025226:c1229251-1228862 [Saccharolobus caldissimus]
MIVVDTNILVYSTFEDSENHSKALEIIEKEDVKIPQIVVYEFLWVLAKLTSDVSLIKTKIEELREFEIICESPEIIFNGV
KMLKEDGKPLKMLNDYVILALAKELKGDLATYDEKLRKIAEKHGVRIIP

Download         Length: 390 bp

>T40167 NZ_AP025226:c1229251-1228862 [Saccharolobus caldissimus]
ATGATAGTAGTTGATACGAATATATTAGTTTATTCAACTTTTGAAGATTCCGAAAATCATTCTAAAGCTCTAGAAATTAT
AGAGAAGGAGGACGTTAAAATTCCGCAGATAGTCGTTTATGAGTTCTTATGGGTTTTAGCTAAACTTACATCAGATGTTT
CCTTAATAAAAACTAAGATTGAAGAGTTAAGAGAGTTTGAAATTATATGCGAAAGCCCGGAAATCATATTCAATGGTGTA
AAAATGTTAAAGGAAGACGGTAAACCTTTAAAGATGTTAAATGATTACGTTATTCTAGCCTTAGCTAAGGAATTAAAAGG
AGATTTAGCAACCTATGATGAAAAATTAAGGAAAATTGCTGAAAAACATGGTGTAAGAATAATTCCTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8592.85 Da        Isoelectric Point: 6.3410

>AT40167 WP_229572255.1 NZ_AP025226:c1229465-1229238 [Saccharolobus caldissimus]
MKVKVTRNFQVTIPSEIREKLGIKEGDYVEVTLDESNGTIIIKPYIRKWTTIRLNKKVGQEDIDKAVEEALNDSS

Download         Length: 228 bp

>AT40167 NZ_AP025226:c1229465-1229238 [Saccharolobus caldissimus]
ATGAAAGTAAAGGTTACTAGAAACTTTCAGGTTACTATACCCTCAGAGATAAGAGAAAAATTAGGTATAAAGGAAGGAGA
TTATGTCGAAGTAACTTTGGATGAAAGTAATGGAACTATAATAATTAAACCGTATATAAGAAAGTGGACTACAATAAGGT
TGAATAAAAAAGTGGGCCAGGAGGATATAGATAAGGCAGTTGAGGAGGCACTAAATGATAGTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References