Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1228862..1229465 Replicon chromosome
Accession NZ_AP025226
Organism Saccharolobus caldissimus strain JCM 32116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SACC_RS07055 Protein ID WP_229572254.1
Coordinates 1228862..1229251 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SACC_RS07060 Protein ID WP_229572255.1
Coordinates 1229238..1229465 (-) Length 76 a.a.

Genomic Context

SACC_RS07015SACC_RS07025SACC_RS07030SACC_RS16670SACC_RS07035SACC_RS07065SACC_RS07070SACC_RS07075SACC_RS07020SACC_RS07040SACC_RS07045SACC_RS07050SACC_RS07055SACC_RS07060SACC_RS07080SACC_RS07085
Location: 1224292..1224483 (192 bp)
Type: Others
Protein ID: WP_229572246.1
Location: 1226287..1226475 (189 bp)
Type: Others
Protein ID: WP_229572248.1
Location: 1226728..1226946 (219 bp)
Type: Others
Protein ID: WP_229572249.1
Location: 1226954..1227088 (135 bp)
Type: Others
Protein ID: WP_282099535.1
Location: 1227081..1227545 (465 bp)
Type: Others
Protein ID: WP_229572250.1
Location: 1229734..1230114 (381 bp)
Type: Others
Protein ID: WP_229572256.1
Location: 1230080..1230442 (363 bp)
Type: Others
Protein ID: WP_229572257.1
Location: 1230729..1232153 (1425 bp)
Type: Others
Protein ID: WP_229572258.1
Location: 1224994..1226163 (1170 bp)
Type: Others
Protein ID: WP_229572247.1
Location: 1227834..1228169 (336 bp)
Type: Others
Protein ID: WP_229572251.1
Location: 1228154..1228354 (201 bp)
Type: Others
Protein ID: WP_229572252.1
Location: 1228519..1228776 (258 bp)
Type: Others
Protein ID: WP_229572253.1
Location: 1228862..1229251 (390 bp)
Type: Toxin
Protein ID: WP_229572254.1
Location: 1229238..1229465 (228 bp)
Type: Antitoxin
Protein ID: WP_229572255.1
Location: 1232156..1233451 (1296 bp)
Type: Others
Protein ID: WP_229572259.1
Location: 1233456..1234271 (816 bp)
Type: Others
Protein ID: WP_229572260.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SACC_RS07015 (SACC_13820)1224292..1224483+192WP_229572246.1hypothetical protein-
SACC_RS07020 (SACC_13830)1224994..1226163-1170WP_229572247.1aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme-
SACC_RS07025 (SACC_13840)1226287..1226475+189WP_229572248.1hypothetical protein-
SACC_RS07030 (SACC_13850)1226728..1226946+219WP_229572249.1hypothetical protein-
SACC_RS16670 (SACC_13860)1226954..1227088+135WP_282099535.1hypothetical protein-
SACC_RS07035 (SACC_13870)1227081..1227545+465WP_229572250.1HAD-IA family hydrolase-
SACC_RS07040 (SACC_13880)1227834..1228169-336WP_229572251.1nucleotidyltransferase domain-containing protein-
SACC_RS07045 (SACC_13890)1228154..1228354-201WP_229572252.1HEPN domain-containing protein-
SACC_RS07050 (SACC_13900)1228519..1228776-258WP_229572253.1HEPN domain-containing protein-
SACC_RS07055 (SACC_13910)1228862..1229251-390WP_229572254.1PIN domain-containing proteinToxin
SACC_RS07060 (SACC_13920)1229238..1229465-228WP_229572255.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
SACC_RS07065 (SACC_13930)1229734..1230114+381WP_229572256.1PaREP1 family protein-
SACC_RS07070 (SACC_13940)1230080..1230442+363WP_229572257.1PaREP1 family protein-
SACC_RS07075 (SACC_13950)1230729..1232153+1425WP_229572258.1phenylacetate--CoA ligase family protein-
SACC_RS07080 (SACC_13960)1232156..1233451-1296WP_229572259.1hydroxyacid-oxoacid transhydrogenase-
SACC_RS07085 (SACC_13970)1233456..1234271-816WP_229572260.1N-acyl homoserine lactonase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(3-47)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14848.46 Da        Isoelectric Point: 4.7430

>T40167 WP_229572254.1 NZ_AP025226:c1229251-1228862 [Saccharolobus caldissimus]
MIVVDTNILVYSTFEDSENHSKALEIIEKEDVKIPQIVVYEFLWVLAKLTSDVSLIKTKIEELREFEIICESPEIIFNGV
KMLKEDGKPLKMLNDYVILALAKELKGDLATYDEKLRKIAEKHGVRIIP

Download         Length: 390 bp

>T40167 NZ_AP025226:c1229251-1228862 [Saccharolobus caldissimus]
ATGATAGTAGTTGATACGAATATATTAGTTTATTCAACTTTTGAAGATTCCGAAAATCATTCTAAAGCTCTAGAAATTAT
AGAGAAGGAGGACGTTAAAATTCCGCAGATAGTCGTTTATGAGTTCTTATGGGTTTTAGCTAAACTTACATCAGATGTTT
CCTTAATAAAAACTAAGATTGAAGAGTTAAGAGAGTTTGAAATTATATGCGAAAGCCCGGAAATCATATTCAATGGTGTA
AAAATGTTAAAGGAAGACGGTAAACCTTTAAAGATGTTAAATGATTACGTTATTCTAGCCTTAGCTAAGGAATTAAAAGG
AGATTTAGCAACCTATGATGAAAAATTAAGGAAAATTGCTGAAAAACATGGTGTAAGAATAATTCCTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8592.85 Da        Isoelectric Point: 6.3410

>AT40167 WP_229572255.1 NZ_AP025226:c1229465-1229238 [Saccharolobus caldissimus]
MKVKVTRNFQVTIPSEIREKLGIKEGDYVEVTLDESNGTIIIKPYIRKWTTIRLNKKVGQEDIDKAVEEALNDSS

Download         Length: 228 bp

>AT40167 NZ_AP025226:c1229465-1229238 [Saccharolobus caldissimus]
ATGAAAGTAAAGGTTACTAGAAACTTTCAGGTTACTATACCCTCAGAGATAAGAGAAAAATTAGGTATAAAGGAAGGAGA
TTATGTCGAAGTAACTTTGGATGAAAGTAATGGAACTATAATAATTAAACCGTATATAAGAAAGTGGACTACAATAAGGT
TGAATAAAAAAGTGGGCCAGGAGGATATAGATAAGGCAGTTGAGGAGGCACTAAATGATAGTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References