Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1977855..1978642 | Replicon | chromosome |
| Accession | NZ_AP025214 | ||
| Organism | Escherichia coli strain 2017.09.02CC | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | LPH32_RS09875 | Protein ID | WP_001614355.1 |
| Coordinates | 1978265..1978642 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2H9G3E7 |
| Locus tag | LPH32_RS09870 | Protein ID | WP_000066236.1 |
| Coordinates | 1977855..1978214 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH32_RS09830 (1973543) | 1973543..1974178 | + | 636 | WP_040220404.1 | hypothetical protein | - |
| LPH32_RS09835 (1974214) | 1974214..1974666 | + | 453 | WP_001020418.1 | hypothetical protein | - |
| LPH32_RS09840 (1974663) | 1974663..1975112 | + | 450 | WP_040220400.1 | IrmA family protein | - |
| LPH32_RS09845 (1975189) | 1975189..1975422 | + | 234 | WP_001614358.1 | DUF905 domain-containing protein | - |
| LPH32_RS09850 (1975542) | 1975542..1976360 | + | 819 | WP_001234406.1 | DUF932 domain-containing protein | - |
| LPH32_RS09855 (1976628) | 1976628..1977098 | + | 471 | WP_000131762.1 | antirestriction protein | - |
| LPH32_RS09860 (1977110) | 1977110..1977589 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| LPH32_RS09865 (1977610) | 1977610..1977831 | + | 222 | WP_000691981.1 | DUF987 domain-containing protein | - |
| LPH32_RS09870 (1977855) | 1977855..1978214 | + | 360 | WP_000066236.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LPH32_RS09875 (1978265) | 1978265..1978642 | + | 378 | WP_001614355.1 | TA system toxin CbtA family protein | Toxin |
| LPH32_RS09880 (1978639) | 1978639..1979130 | + | 492 | WP_000777682.1 | DUF5983 family protein | - |
| LPH32_RS09885 (1979162) | 1979162..1979365 | + | 204 | WP_000413747.1 | DUF957 domain-containing protein | - |
| LPH32_RS09890 (1979446) | 1979446..1980297 | + | 852 | WP_001614353.1 | DUF4942 domain-containing protein | - |
| LPH32_RS09900 (1980628) | 1980628..1981359 | - | 732 | WP_024185250.1 | DNA polymerase III subunit epsilon | - |
| LPH32_RS09905 (1981424) | 1981424..1981891 | + | 468 | WP_000917883.1 | ribonuclease HI | - |
| LPH32_RS09910 (1981888) | 1981888..1982610 | - | 723 | WP_001308373.1 | class I SAM-dependent methyltransferase | - |
| LPH32_RS09915 (1982644) | 1982644..1983399 | + | 756 | WP_053290631.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1951035..1988995 | 37960 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14214.99 Da Isoelectric Point: 7.4209
>T40131 WP_001614355.1 NZ_AP025214:1978265-1978642 [Escherichia coli]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLFDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLFDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T40131 NZ_AP025214:1978265-1978642 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTTGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTTGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13127.02 Da Isoelectric Point: 7.0261
>AT40131 WP_000066236.1 NZ_AP025214:1977855-1978214 [Escherichia coli]
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 360 bp
>AT40131 NZ_AP025214:1977855-1978214 [Escherichia coli]
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGTCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGTCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|