Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2463741..2464267 | Replicon | chromosome |
| Accession | NZ_AP025209 | ||
| Organism | Escherichia coli strain 2017.06.04CC | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LPH28_RS11875 | Protein ID | WP_000323025.1 |
| Coordinates | 2463741..2464028 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LPH28_RS11880 | Protein ID | WP_000534858.1 |
| Coordinates | 2464028..2464267 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH28_RS11840 (2459423) | 2459423..2460382 | - | 960 | WP_000592549.1 | DUF523 and DUF1722 domain-containing protein | - |
| LPH28_RS11845 (2460575) | 2460575..2461099 | + | 525 | WP_000780584.1 | lipocalin family protein | - |
| LPH28_RS11850 (2461255) | 2461255..2461632 | - | 378 | WP_001204787.1 | antiterminator Q family protein | - |
| LPH28_RS11855 (2461650) | 2461650..2462699 | - | 1050 | WP_229433885.1 | DUF968 domain-containing protein | - |
| LPH28_RS11860 (2462701) | 2462701..2462979 | - | 279 | WP_112951986.1 | hypothetical protein | - |
| LPH28_RS11865 (2463046) | 2463046..2463297 | - | 252 | WP_001463433.1 | protein Rem | - |
| LPH28_RS11870 (2463514) | 2463514..2463669 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| LPH28_RS11875 (2463741) | 2463741..2464028 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LPH28_RS11880 (2464028) | 2464028..2464267 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LPH28_RS11885 (2464292) | 2464292..2464597 | + | 306 | WP_071593935.1 | protein YdfV | - |
| LPH28_RS11890 (2464800) | 2464800..2464916 | + | 117 | Protein_2330 | protein FlxA | - |
| LPH28_RS11895 (2464987) | 2464987..2465388 | + | 402 | WP_014639829.1 | transposase | - |
| LPH28_RS11900 (2465385) | 2465385..2465732 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| LPH28_RS11905 (2465781) | 2465781..2467319 | + | 1539 | WP_000099170.1 | IS66-like element ISEc22 family transposase | - |
| LPH28_RS11910 (2467357) | 2467357..2467581 | + | 225 | Protein_2334 | FlxA-like family protein | - |
| LPH28_RS11915 (2468018) | 2468018..2468167 | - | 150 | WP_011443592.1 | protein YdfW | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2448354..2489873 | 41519 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T40108 WP_000323025.1 NZ_AP025209:c2464028-2463741 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T40108 NZ_AP025209:c2464028-2463741 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT40108 WP_000534858.1 NZ_AP025209:c2464267-2464028 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT40108 NZ_AP025209:c2464267-2464028 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|