Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3936273..3937105 Replicon chromosome
Accession NZ_AP025205
Organism Escherichia coli strain 2017.04.03CC

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag LPH27_RS18935 Protein ID WP_000854765.1
Coordinates 3936273..3936647 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A403D757
Locus tag LPH27_RS18940 Protein ID WP_016230789.1
Coordinates 3936737..3937105 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH27_RS18915 (3931791) 3931791..3934682 - 2892 WP_000580532.1 SNF2-related protein -
LPH27_RS18920 (3935337) 3935337..3935486 - 150 Protein_3696 hypothetical protein -
LPH27_RS18925 (3935592) 3935592..3935768 - 177 WP_000839290.1 DUF957 domain-containing protein -
LPH27_RS18930 (3935785) 3935785..3936276 - 492 WP_000976842.1 DUF5983 family protein -
LPH27_RS18935 (3936273) 3936273..3936647 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
LPH27_RS18940 (3936737) 3936737..3937105 - 369 WP_016230789.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LPH27_RS18945 (3937268) 3937268..3937489 - 222 WP_000692345.1 DUF987 domain-containing protein -
LPH27_RS18950 (3937552) 3937552..3938028 - 477 WP_001186774.1 RadC family protein -
LPH27_RS18955 (3938044) 3938044..3938529 - 486 WP_229266177.1 antirestriction protein -
LPH27_RS18960 (3938584) 3938584..3939402 - 819 WP_112037995.1 DUF932 domain-containing protein -
LPH27_RS18965 (3939502) 3939502..3939735 - 234 WP_001119717.1 DUF905 family protein -
LPH27_RS18970 (3939814) 3939814..3940268 - 455 Protein_3706 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T40087 WP_000854765.1 NZ_AP025205:c3936647-3936273 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T40087 NZ_AP025205:c3936647-3936273 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.45 Da        Isoelectric Point: 7.0264

>AT40087 WP_016230789.1 NZ_AP025205:c3937105-3936737 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT40087 NZ_AP025205:c3937105-3936737 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A403D757

References