Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2746894..2747729 | Replicon | chromosome |
| Accession | NZ_AP025205 | ||
| Organism | Escherichia coli strain 2017.04.03CC | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6H2GFM1 |
| Locus tag | LPH27_RS13330 | Protein ID | WP_065304416.1 |
| Coordinates | 2746894..2747271 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A6H2GGB7 |
| Locus tag | LPH27_RS13335 | Protein ID | WP_001285390.1 |
| Coordinates | 2747361..2747729 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH27_RS13290 (2742158) | 2742158..2742649 | - | 492 | WP_001300785.1 | DUF1097 domain-containing protein | - |
| LPH27_RS13295 (2742751) | 2742751..2743305 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| LPH27_RS13300 (2743329) | 2743329..2744066 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| LPH27_RS13305 (2744121) | 2744121..2745059 | - | 939 | WP_000351315.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| LPH27_RS13315 (2745530) | 2745530..2746372 | - | 843 | WP_065304417.1 | DUF4942 domain-containing protein | - |
| LPH27_RS13320 (2746469) | 2746469..2746672 | - | 204 | WP_229266309.1 | hypothetical protein | - |
| LPH27_RS13325 (2746748) | 2746748..2746897 | - | 150 | Protein_2606 | DUF5983 family protein | - |
| LPH27_RS13330 (2746894) | 2746894..2747271 | - | 378 | WP_065304416.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| LPH27_RS13335 (2747361) | 2747361..2747729 | - | 369 | WP_001285390.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LPH27_RS13340 (2747779) | 2747779..2748423 | - | 645 | WP_065304415.1 | antitoxin of toxin-antitoxin stability system | - |
| LPH27_RS13345 (2748438) | 2748438..2748659 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| LPH27_RS13350 (2748728) | 2748728..2749204 | - | 477 | WP_001186747.1 | RadC family protein | - |
| LPH27_RS13355 (2749219) | 2749219..2749704 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| LPH27_RS13360 (2749795) | 2749795..2750613 | - | 819 | WP_112923394.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | csgC / csgA / csgB / csgD / csgE / csgF / csgG | 2737652..2766273 | 28621 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14060.06 Da Isoelectric Point: 7.8522
>T40082 WP_065304416.1 NZ_AP025205:c2747271-2746894 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ
Download Length: 378 bp
>T40082 NZ_AP025205:c2747271-2746894 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13811.52 Da Isoelectric Point: 5.9618
>AT40082 WP_001285390.1 NZ_AP025205:c2747729-2747361 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT40082 NZ_AP025205:c2747729-2747361 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAACATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAACATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H2GFM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H2GGB7 |