Detailed information of TA system TA040060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2883825..2884777
• Replicon: chromosome
• Accession: NZ_AP025186
• Organism: Rhodococcus sp. RDE2

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: LPH33_RS13415
• Protein ID: WP_160877732.1
• Coordinates: 2883825..2884394 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: LPH33_RS13420
• Protein ID: WP_160877730.1
• Coordinates: 2884391..2884777 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH33_RS13395 (RDE2_26690)	2879017..2880132	+	1116	WP_160877700.1	FAD-dependent monooxygenase	-
LPH33_RS13400 (RDE2_26700)	2880176..2881108	+	933	WP_160877738.1	alpha/beta hydrolase	-
LPH33_RS13405 (RDE2_26710)	2881101..2882057	+	957	WP_229564928.1	MBL fold metallo-hydrolase	-
LPH33_RS13410 (RDE2_26720)	2882064..2883791	+	1728	WP_229564929.1	CocE/NonD family hydrolase	-
LPH33_RS13415 (RDE2_26730)	2883825..2884394	-	570	WP_160877732.1	zeta toxin family protein	Toxin
LPH33_RS13420 (RDE2_26740)	2884391..2884777	-	387	WP_160877730.1	hypothetical protein	Antitoxin
LPH33_RS13425 (RDE2_26750)	2884982..2886052	+	1071	WP_229564930.1	methyltransferase domain-containing protein	-
LPH33_RS13430 (RDE2_26760)	2886122..2886493	+	372	WP_160877726.1	HNH endonuclease	-
LPH33_RS13435 (RDE2_26770)	2886519..2887295	-	777	WP_229564931.1	CPBP family intramembrane metalloprotease	-
LPH33_RS13440 (RDE2_26780)	2887404..2887763	-	360	WP_229564932.1	hypothetical protein	-
LPH33_RS13445 (RDE2_26790)	2888482..2889414	-	933	WP_229564933.1	TAXI family TRAP transporter solute-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-102)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20538.74 Da
• Isoelectric Point: 10.4012

>T40060 WP_160877732.1 NZ_AP025186:c2884394-2883825 [Rhodococcus sp. RDE2]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEAGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTACGTP
VVVARFAGGVPVGAVRWPGWVPAALTGLG

Nucleotide

• Length: 570 bp

>T40060 NZ_AP025186:c2884394-2883825 [Rhodococcus sp. RDE2]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAATGGTTCCGGTAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGTGTGTTCGTCAACGCGGATGTGATCGCGCGGCAGCGTTGGCCCGACCGTGCCGAGGAGATGTCGTACGAGG
CGGCGCAACTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATCGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGCTGATCGACCGGGCACACGAGGCGGGCTTCACGGTGGTGCTGCATGTGATGCTGGTGCCGGAGGC
GATGTCGGTGCTGCGTGTGCAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GACGGTTGTGGCCGCTGGTGGCCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTGCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGTGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14008.51 Da
• Isoelectric Point: 4.8265

>AT40060 WP_160877730.1 NZ_AP025186:c2884777-2884391 [Rhodococcus sp. RDE2]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLVRTDYAAVLAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Nucleotide

• Length: 387 bp

>AT40060 NZ_AP025186:c2884777-2884391 [Rhodococcus sp. RDE2]
ATGACGTCGTCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCTATCGCGGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGTATCGGCCGCGCGATGACCGCCCATGAGACCGCCTCCTTGCACC
GGGTGCACGAGGCGCTGGCCGGGACGCGGGAGCTGAGCGAGCTCACCGCCGCGGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGTCCGCACCGATTACGCCGCGGTGCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAGGGCCGGTTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA