Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5413696..5414355 Replicon chromosome
Accession NZ_AP025179
Organism Mycobacterium kiyosense strain IWGMT90018-18076

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag L6444_RS25370 Protein ID WP_236977931.1
Coordinates 5413696..5414169 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag L6444_RS25375 Protein ID WP_236977932.1
Coordinates 5414176..5414355 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6444_RS25350 (IWGMT90018_53040) 5409424..5409891 + 468 WP_236977923.1 VOC family protein -
L6444_RS25355 5409904..5410329 - 426 WP_236977925.1 hypothetical protein -
L6444_RS25360 (IWGMT90018_53070) 5410465..5410770 + 306 WP_236977927.1 hypothetical protein -
L6444_RS25365 (IWGMT90018_53080) 5410774..5413551 - 2778 WP_236977929.1 LuxR family transcriptional regulator -
L6444_RS25370 (IWGMT90018_53090) 5413696..5414169 - 474 WP_236977931.1 SRPBCC family protein Toxin
L6444_RS25375 (IWGMT90018_53100) 5414176..5414355 - 180 WP_236977932.1 antitoxin Antitoxin
L6444_RS25380 5414426..5416804 - 2379 WP_236977933.1 cation-translocating P-type ATPase -
L6444_RS25385 5416801..5418382 - 1582 Protein_5065 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17128.80 Da        Isoelectric Point: 9.7966

>T40024 WP_236977931.1 NZ_AP025179:c5414169-5413696 [Mycobacterium kiyosense]
MAKLSGAIDVPLPPERAWQHASDLSRYKEWLTIHKVWRSTLPEVIEKGTVLESYVEVKGMTNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVSPKDDGSVVGFDVHLGGPALFGPIGMVVAAALRSDISESLQNFVRVFARPDPGTNGDSVLHR

Download         Length: 474 bp

>T40024 NZ_AP025179:c5414169-5413696 [Mycobacterium kiyosense]
ATGGCGAAACTGTCGGGAGCCATCGACGTCCCGTTGCCGCCCGAACGGGCGTGGCAACACGCCTCGGATCTGTCCCGGTA
CAAGGAGTGGCTGACCATCCACAAGGTCTGGCGCAGCACCTTGCCCGAGGTCATCGAGAAGGGCACCGTGCTGGAGTCCT
ATGTGGAGGTCAAAGGTATGACCAACCGGATCAAGTGGACGATCGTGCGGTACAAGCCGCCCGAGGGCATGACCCTCAAC
GGCGACGGTGTCGGCGGGGTGAAGGTGAAGCTGATTGCCAAGGTGTCGCCGAAGGACGACGGCTCGGTGGTTGGCTTCGA
CGTCCACCTCGGCGGGCCGGCGCTGTTCGGGCCGATCGGAATGGTGGTGGCCGCCGCGTTGCGCAGCGACATCAGCGAGT
CGCTGCAGAACTTCGTCAGGGTGTTCGCCCGTCCCGATCCCGGTACGAACGGCGACAGCGTTCTGCACCGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6534.29 Da        Isoelectric Point: 5.6492

>AT40024 WP_236977932.1 NZ_AP025179:c5414355-5414176 [Mycobacterium kiyosense]
MGFMDKAKDLLSQNADKVETAINKAGEFVDEKTQHKYSDTIHKVQEEAKKVAAPGEQQG

Download         Length: 180 bp

>AT40024 NZ_AP025179:c5414355-5414176 [Mycobacterium kiyosense]
ATGGGTTTCATGGATAAAGCGAAGGACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGCAATCAACAAGGCCGGCGA
ATTCGTCGACGAGAAGACGCAGCACAAATACTCCGACACCATCCACAAGGTGCAGGAGGAAGCCAAGAAGGTCGCCGCAC
CGGGCGAGCAGCAGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References