Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3942873..3943507 Replicon chromosome
Accession NZ_AP025179
Organism Mycobacterium kiyosense strain IWGMT90018-18076

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6444_RS18495 Protein ID WP_236976442.1
Coordinates 3942873..3943274 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6444_RS18500 Protein ID WP_236976443.1
Coordinates 3943271..3943507 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6444_RS18470 (IWGMT90018_38620) 3938219..3938533 + 315 WP_236976435.1 putative quinol monooxygenase -
L6444_RS18475 (IWGMT90018_38630) 3938530..3939351 + 822 WP_236984249.1 mycofactocin-coupled SDR family oxidoreductase -
L6444_RS18480 (IWGMT90018_38640) 3939356..3940228 + 873 WP_236976437.1 SAM-dependent methyltransferase -
L6444_RS18485 (IWGMT90018_38650) 3940225..3941901 - 1677 WP_236976439.1 ribonuclease J -
L6444_RS18490 (IWGMT90018_38660) 3941909..3942811 - 903 WP_236976441.1 4-hydroxy-tetrahydrodipicolinate synthase -
L6444_RS18495 (IWGMT90018_38670) 3942873..3943274 - 402 WP_236976442.1 type II toxin-antitoxin system VapC family toxin Toxin
L6444_RS18500 (IWGMT90018_38680) 3943271..3943507 - 237 WP_236976443.1 BrnA antitoxin family protein Antitoxin
L6444_RS18505 (IWGMT90018_38690) 3943610..3944371 - 762 WP_236976444.1 FAD-dependent thymidylate synthase -
L6444_RS18510 3944426..3944665 - 240 Protein_3690 glycosyltransferase -
L6444_RS18515 (IWGMT90018_38700) 3944905..3946443 - 1539 WP_236976445.1 type I restriction-modification system subunit M -
L6444_RS18520 (IWGMT90018_38710) 3946456..3947229 - 774 WP_236976446.1 hypothetical protein -
L6444_RS18525 3947264..3947548 - 285 WP_236976447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14708.99 Da        Isoelectric Point: 8.1422

>T40023 WP_236976442.1 NZ_AP025179:c3943274-3942873 [Mycobacterium kiyosense]
VKDFVIDASALVLSLVGKTAAADALRQRLPQMRRHAPHLIDAEVGNVLRRHERAGLISAREAETALRMLDALVDNRYPHA
GMLARRAWEMRHHVSFYDELYAALAGHLDIPLLTADARLDRAAGLACRVEVVG

Download         Length: 402 bp

>T40023 NZ_AP025179:c3943274-3942873 [Mycobacterium kiyosense]
GTGAAGGACTTTGTCATCGATGCGTCGGCATTAGTGCTGAGCCTGGTCGGTAAGACCGCCGCAGCGGACGCGTTGCGGCA
GCGGCTGCCTCAGATGCGCCGACATGCGCCGCACCTGATCGACGCGGAGGTGGGAAATGTGCTGCGCCGTCACGAGCGGG
CCGGGCTCATAAGCGCCAGAGAAGCTGAAACGGCGCTGCGGATGCTCGATGCACTGGTAGACAACCGCTACCCACATGCC
GGGATGTTGGCTCGCCGAGCGTGGGAAATGCGGCACCACGTCAGCTTCTACGACGAGCTTTATGCAGCCCTTGCCGGACA
TCTTGACATCCCGCTACTCACTGCGGATGCCCGCCTCGATCGCGCGGCAGGCCTGGCATGTCGCGTCGAAGTGGTCGGAT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8643.72 Da        Isoelectric Point: 4.7719

>AT40023 WP_236976443.1 NZ_AP025179:c3943507-3943271 [Mycobacterium kiyosense]
VATIQIREIPEDAYLVIRNRARAAGRSLQSYMRDWVVDFANRPTPAEALEEMAAARKAGDTPAATTESILADLAEDRR

Download         Length: 237 bp

>AT40023 NZ_AP025179:c3943507-3943271 [Mycobacterium kiyosense]
GTGGCGACCATACAGATCCGGGAAATCCCCGAGGATGCCTACCTGGTCATCCGAAATCGTGCCCGCGCCGCGGGGCGATC
GCTGCAGTCGTACATGCGCGACTGGGTGGTCGATTTCGCCAACCGCCCCACTCCGGCTGAGGCGCTGGAAGAAATGGCGG
CGGCACGGAAGGCGGGCGATACTCCGGCCGCCACAACGGAATCCATCCTCGCCGATTTGGCCGAAGACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References