Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 2878697..2879331 | Replicon | chromosome |
Accession | NZ_AP025179 | ||
Organism | Mycobacterium kiyosense strain IWGMT90018-18076 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | L6444_RS13615 | Protein ID | WP_236983335.1 |
Coordinates | 2878697..2879077 (-) | Length | 127 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | L6444_RS13620 | Protein ID | WP_236983337.1 |
Coordinates | 2879074..2879331 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L6444_RS13585 (IWGMT90018_28340) | 2874590..2875555 | - | 966 | WP_236983322.1 | hypothetical protein | - |
L6444_RS13590 (IWGMT90018_28350) | 2876067..2876417 | - | 351 | WP_236983324.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
L6444_RS13595 (IWGMT90018_28360) | 2876399..2876632 | - | 234 | WP_236983326.1 | hypothetical protein | - |
L6444_RS13600 (IWGMT90018_28370) | 2876772..2877284 | - | 513 | WP_236983328.1 | HXXEE domain-containing protein | - |
L6444_RS13605 (IWGMT90018_28380) | 2877653..2878078 | - | 426 | WP_236983330.1 | PIN domain-containing protein | - |
L6444_RS13610 (IWGMT90018_28390) | 2878069..2878275 | - | 207 | WP_236983333.1 | DUF2191 domain-containing protein | - |
L6444_RS13615 (IWGMT90018_28410) | 2878697..2879077 | - | 381 | WP_236983335.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
L6444_RS13620 (IWGMT90018_28420) | 2879074..2879331 | - | 258 | WP_236983337.1 | CopG family transcriptional regulator | Antitoxin |
L6444_RS13625 (IWGMT90018_28430) | 2880142..2880513 | - | 372 | WP_236984113.1 | FHA domain-containing protein | - |
L6444_RS13630 (IWGMT90018_28440) | 2880744..2881082 | + | 339 | WP_236983339.1 | hypothetical protein | - |
L6444_RS13635 (IWGMT90018_28450) | 2881247..2881870 | - | 624 | WP_236983341.1 | TetR/AcrR family transcriptional regulator | - |
L6444_RS13640 (IWGMT90018_28460) | 2881946..2882695 | + | 750 | WP_236983343.1 | hypothetical protein | - |
L6444_RS13645 (IWGMT90018_28470) | 2882833..2883123 | + | 291 | WP_236983345.1 | hypothetical protein | - |
L6444_RS13650 (IWGMT90018_28480) | 2883244..2883777 | - | 534 | WP_236984115.1 | ZIP family metal transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2864147..2883123 | 18976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14107.33 Da Isoelectric Point: 10.7075
>T40021 WP_236983335.1 NZ_AP025179:c2879077-2878697 [Mycobacterium kiyosense]
MMLVDSDILIAHLRGRAAARDWLRDARGEGPLAISVVSISELVGGMRSAERREVWQLLASFRAEPTTEIIARRAGDFMRR
YQRSHSGIGLGDYLVAAAADVKGYEPATLNVKHFPMFKNLRPPFRL
MMLVDSDILIAHLRGRAAARDWLRDARGEGPLAISVVSISELVGGMRSAERREVWQLLASFRAEPTTEIIARRAGDFMRR
YQRSHSGIGLGDYLVAAAADVKGYEPATLNVKHFPMFKNLRPPFRL
Download Length: 381 bp
>T40021 NZ_AP025179:c2879077-2878697 [Mycobacterium kiyosense]
ATGATGCTGGTCGACTCAGACATCCTCATCGCCCACCTCCGTGGCAGGGCCGCGGCGCGTGATTGGCTCCGTGATGCTCG
GGGGGAGGGGCCGTTAGCGATCAGCGTGGTGTCGATTAGCGAACTGGTCGGCGGGATGCGCAGCGCGGAGCGGCGCGAGG
TATGGCAGCTGCTCGCGTCGTTTCGTGCCGAACCGACCACCGAGATCATCGCGCGGCGGGCCGGTGACTTCATGCGCCGG
TATCAACGGAGTCATAGCGGTATCGGTTTGGGTGACTATCTGGTTGCTGCGGCCGCCGACGTCAAGGGTTATGAGCCGGC
GACGCTGAACGTGAAGCATTTCCCGATGTTCAAGAACCTGCGGCCGCCATTCAGACTCTGA
ATGATGCTGGTCGACTCAGACATCCTCATCGCCCACCTCCGTGGCAGGGCCGCGGCGCGTGATTGGCTCCGTGATGCTCG
GGGGGAGGGGCCGTTAGCGATCAGCGTGGTGTCGATTAGCGAACTGGTCGGCGGGATGCGCAGCGCGGAGCGGCGCGAGG
TATGGCAGCTGCTCGCGTCGTTTCGTGCCGAACCGACCACCGAGATCATCGCGCGGCGGGCCGGTGACTTCATGCGCCGG
TATCAACGGAGTCATAGCGGTATCGGTTTGGGTGACTATCTGGTTGCTGCGGCCGCCGACGTCAAGGGTTATGAGCCGGC
GACGCTGAACGTGAAGCATTTCCCGATGTTCAAGAACCTGCGGCCGCCATTCAGACTCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9786.94 Da Isoelectric Point: 5.1342
>AT40021 WP_236983337.1 NZ_AP025179:c2879331-2879074 [Mycobacterium kiyosense]
MKRTNIYLDEAQTISLDKLAEQQGISRAELIRQLLDRALNNADDNLAADLKAIDDSFGVLRDIEAPDRRPGSREQHLERM
WRHTS
MKRTNIYLDEAQTISLDKLAEQQGISRAELIRQLLDRALNNADDNLAADLKAIDDSFGVLRDIEAPDRRPGSREQHLERM
WRHTS
Download Length: 258 bp
>AT40021 NZ_AP025179:c2879331-2879074 [Mycobacterium kiyosense]
ATGAAGCGCACCAATATCTATCTCGACGAGGCCCAGACAATCAGCCTCGACAAGTTGGCCGAGCAACAAGGCATTTCCCG
CGCCGAGCTCATTCGCCAGCTGTTGGATCGCGCTCTCAACAACGCAGACGACAACCTTGCTGCCGACCTCAAAGCGATTG
ACGATTCGTTCGGCGTTCTGCGCGATATCGAGGCACCCGATCGTCGACCCGGCAGCCGCGAGCAGCATCTCGAGCGGATG
TGGCGCCACACCTCATGA
ATGAAGCGCACCAATATCTATCTCGACGAGGCCCAGACAATCAGCCTCGACAAGTTGGCCGAGCAACAAGGCATTTCCCG
CGCCGAGCTCATTCGCCAGCTGTTGGATCGCGCTCTCAACAACGCAGACGACAACCTTGCTGCCGACCTCAAAGCGATTG
ACGATTCGTTCGGCGTTCTGCGCGATATCGAGGCACCCGATCGTCGACCCGGCAGCCGCGAGCAGCATCTCGAGCGGATG
TGGCGCCACACCTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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