Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2878697..2879331 Replicon chromosome
Accession NZ_AP025179
Organism Mycobacterium kiyosense strain IWGMT90018-18076

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6444_RS13615 Protein ID WP_236983335.1
Coordinates 2878697..2879077 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6444_RS13620 Protein ID WP_236983337.1
Coordinates 2879074..2879331 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6444_RS13585 (IWGMT90018_28340) 2874590..2875555 - 966 WP_236983322.1 hypothetical protein -
L6444_RS13590 (IWGMT90018_28350) 2876067..2876417 - 351 WP_236983324.1 type II toxin-antitoxin system PemK/MazF family toxin -
L6444_RS13595 (IWGMT90018_28360) 2876399..2876632 - 234 WP_236983326.1 hypothetical protein -
L6444_RS13600 (IWGMT90018_28370) 2876772..2877284 - 513 WP_236983328.1 HXXEE domain-containing protein -
L6444_RS13605 (IWGMT90018_28380) 2877653..2878078 - 426 WP_236983330.1 PIN domain-containing protein -
L6444_RS13610 (IWGMT90018_28390) 2878069..2878275 - 207 WP_236983333.1 DUF2191 domain-containing protein -
L6444_RS13615 (IWGMT90018_28410) 2878697..2879077 - 381 WP_236983335.1 type II toxin-antitoxin system VapC family toxin Toxin
L6444_RS13620 (IWGMT90018_28420) 2879074..2879331 - 258 WP_236983337.1 CopG family transcriptional regulator Antitoxin
L6444_RS13625 (IWGMT90018_28430) 2880142..2880513 - 372 WP_236984113.1 FHA domain-containing protein -
L6444_RS13630 (IWGMT90018_28440) 2880744..2881082 + 339 WP_236983339.1 hypothetical protein -
L6444_RS13635 (IWGMT90018_28450) 2881247..2881870 - 624 WP_236983341.1 TetR/AcrR family transcriptional regulator -
L6444_RS13640 (IWGMT90018_28460) 2881946..2882695 + 750 WP_236983343.1 hypothetical protein -
L6444_RS13645 (IWGMT90018_28470) 2882833..2883123 + 291 WP_236983345.1 hypothetical protein -
L6444_RS13650 (IWGMT90018_28480) 2883244..2883777 - 534 WP_236984115.1 ZIP family metal transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2864147..2883123 18976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(3-39)


Sequences


Toxin        


Download         Length: 127 a.a.        Molecular weight: 14107.33 Da        Isoelectric Point: 10.7075

>T40021 WP_236983335.1 NZ_AP025179:c2879077-2878697 [Mycobacterium kiyosense]
MMLVDSDILIAHLRGRAAARDWLRDARGEGPLAISVVSISELVGGMRSAERREVWQLLASFRAEPTTEIIARRAGDFMRR
YQRSHSGIGLGDYLVAAAADVKGYEPATLNVKHFPMFKNLRPPFRL

Download         Length: 381 bp

>T40021 NZ_AP025179:c2879077-2878697 [Mycobacterium kiyosense]
ATGATGCTGGTCGACTCAGACATCCTCATCGCCCACCTCCGTGGCAGGGCCGCGGCGCGTGATTGGCTCCGTGATGCTCG
GGGGGAGGGGCCGTTAGCGATCAGCGTGGTGTCGATTAGCGAACTGGTCGGCGGGATGCGCAGCGCGGAGCGGCGCGAGG
TATGGCAGCTGCTCGCGTCGTTTCGTGCCGAACCGACCACCGAGATCATCGCGCGGCGGGCCGGTGACTTCATGCGCCGG
TATCAACGGAGTCATAGCGGTATCGGTTTGGGTGACTATCTGGTTGCTGCGGCCGCCGACGTCAAGGGTTATGAGCCGGC
GACGCTGAACGTGAAGCATTTCCCGATGTTCAAGAACCTGCGGCCGCCATTCAGACTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9786.94 Da        Isoelectric Point: 5.1342

>AT40021 WP_236983337.1 NZ_AP025179:c2879331-2879074 [Mycobacterium kiyosense]
MKRTNIYLDEAQTISLDKLAEQQGISRAELIRQLLDRALNNADDNLAADLKAIDDSFGVLRDIEAPDRRPGSREQHLERM
WRHTS

Download         Length: 258 bp

>AT40021 NZ_AP025179:c2879331-2879074 [Mycobacterium kiyosense]
ATGAAGCGCACCAATATCTATCTCGACGAGGCCCAGACAATCAGCCTCGACAAGTTGGCCGAGCAACAAGGCATTTCCCG
CGCCGAGCTCATTCGCCAGCTGTTGGATCGCGCTCTCAACAACGCAGACGACAACCTTGCTGCCGACCTCAAAGCGATTG
ACGATTCGTTCGGCGTTCTGCGCGATATCGAGGCACCCGATCGTCGACCCGGCAGCCGCGAGCAGCATCTCGAGCGGATG
TGGCGCCACACCTCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References