Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-VapB
Location 1843459..1844140 Replicon chromosome
Accession NZ_AP025179
Organism Mycobacterium kiyosense strain IWGMT90018-18076

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6444_RS08775 Protein ID WP_236981739.1
Coordinates 1843459..1843887 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6444_RS08780 Protein ID WP_236981740.1
Coordinates 1843874..1844140 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6444_RS08750 (IWGMT90018_18210) 1838674..1839756 + 1083 WP_236981734.1 tRNA 2-thiouridine(34) synthase MnmA -
L6444_RS08755 (IWGMT90018_18220) 1839763..1840827 - 1065 WP_236981735.1 PE family protein -
L6444_RS08760 (IWGMT90018_18230) 1841101..1841700 + 600 WP_236981736.1 class I SAM-dependent methyltransferase -
L6444_RS08765 (IWGMT90018_18240) 1841717..1842331 - 615 WP_236981737.1 sensor domain-containing protein -
L6444_RS08770 (IWGMT90018_18250) 1842425..1843438 + 1014 WP_236981738.1 methionine synthase -
L6444_RS08775 (IWGMT90018_18260) 1843459..1843887 - 429 WP_236981739.1 type II toxin-antitoxin system VapC family toxin Toxin
L6444_RS08780 (IWGMT90018_18270) 1843874..1844140 - 267 WP_236981740.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L6444_RS08785 1844237..1846325 + 2089 Protein_1750 NAD-dependent DNA ligase LigA -
L6444_RS08790 (IWGMT90018_18300) 1846395..1847003 + 609 WP_236981741.1 TetR/AcrR family transcriptional regulator -
L6444_RS08795 (IWGMT90018_18310) 1847142..1847588 + 447 WP_255731150.1 MmpS family transport accessory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-47)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15646.82 Da        Isoelectric Point: 6.8530

>T40020 WP_236981739.1 NZ_AP025179:c1843887-1843459 [Mycobacterium kiyosense]
MLLLDVNVCLYAIREDSIEHSRYRGSLEDLLNGDEPVGISELVLSGVMRLITNHRIFRQPSSTGQALEACGRLRSAPSAV
VLRPGPRHWDIFDALCAATGARGNTIADAYHAALAIENGATWVTTDRGFARFPGLRWRLPFD

Download         Length: 429 bp

>T40020 NZ_AP025179:c1843887-1843459 [Mycobacterium kiyosense]
ATGCTGCTCCTTGACGTCAACGTCTGCCTCTACGCGATCCGCGAAGACAGCATCGAGCACTCTCGCTACCGCGGGTCGCT
GGAAGATCTGTTGAACGGCGACGAACCGGTGGGGATCAGCGAGCTGGTGCTGTCGGGAGTCATGCGGTTGATCACCAACC
ATCGAATATTTCGGCAGCCCAGTTCCACCGGACAGGCGCTTGAGGCGTGCGGACGGCTGCGGTCCGCGCCGTCCGCCGTG
GTGCTGCGACCGGGGCCGCGGCATTGGGACATCTTCGATGCCCTCTGCGCCGCGACCGGGGCGAGAGGCAACACGATCGC
CGATGCCTACCACGCCGCGTTGGCGATCGAGAACGGCGCAACCTGGGTTACCACCGACCGCGGTTTCGCCCGCTTTCCGG
GCCTTCGCTGGCGCCTTCCATTCGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9415.72 Da        Isoelectric Point: 5.0008

>AT40020 WP_236981740.1 NZ_AP025179:c1844140-1843874 [Mycobacterium kiyosense]
MMLWCTMRTTVNIDDSLLAEAKVLAARTSRSLSAVVEDALRAMLRRDTDTSQRAAFQLATHGTGGLRPGVSLEDKDALAD
ILGDNAAP

Download         Length: 267 bp

>AT40020 NZ_AP025179:c1844140-1843874 [Mycobacterium kiyosense]
ATGATGTTATGGTGCACCATGCGGACGACGGTCAATATCGACGACAGCCTGCTGGCCGAGGCAAAGGTGTTGGCCGCCCG
AACGTCGCGATCCCTGAGCGCCGTGGTGGAGGATGCGTTGCGCGCGATGCTGCGCCGTGACACGGACACATCGCAGCGCG
CAGCATTTCAGCTGGCGACCCATGGAACCGGCGGCTTGCGTCCCGGCGTCAGCCTCGAGGACAAGGACGCCCTCGCCGAC
ATCCTCGGTGACAATGCTGCTCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References