Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1173978..1174612 Replicon chromosome
Accession NZ_AP025179
Organism Mycobacterium kiyosense strain IWGMT90018-18076

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6444_RS05590 Protein ID WP_236981251.1
Coordinates 1173978..1174370 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6444_RS05595 Protein ID WP_236981252.1
Coordinates 1174367..1174612 (-) Length 82 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6444_RS05565 (IWGMT90018_11440) 1169156..1169731 + 576 WP_236981248.1 ECF RNA polymerase sigma factor SigD -
L6444_RS05570 (IWGMT90018_11450) 1169724..1170644 + 921 WP_236981249.1 anti-sigma-D factor RsdA -
L6444_RS05575 (IWGMT90018_11460) 1170661..1171074 - 414 WP_236981250.1 DUF5319 domain-containing protein -
L6444_RS05580 (IWGMT90018_11470) 1171239..1172830 + 1592 Protein_1107 IMP dehydrogenase -
L6444_RS05585 (IWGMT90018_11490) 1172845..1173972 + 1128 WP_236983847.1 GuaB3 family IMP dehydrogenase-related protein -
L6444_RS05590 (IWGMT90018_11500) 1173978..1174370 - 393 WP_236981251.1 type II toxin-antitoxin system VapC family toxin Toxin
L6444_RS05595 (IWGMT90018_11510) 1174367..1174612 - 246 WP_236981252.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L6444_RS05600 (IWGMT90018_11520) 1174685..1176430 + 1746 WP_236981253.1 GMC family oxidoreductase -
L6444_RS05605 (IWGMT90018_11530) 1176658..1177347 - 690 WP_236981254.1 TetR/AcrR family transcriptional regulator -
L6444_RS05610 (IWGMT90018_11540) 1177375..1178475 + 1101 WP_236981255.1 hypothetical protein -
L6444_RS30030 (IWGMT90018_11550) 1178457..1179173 - 717 WP_255731140.1 hypothetical protein -
L6444_RS30035 (IWGMT90018_11560) 1179199..1179369 + 171 WP_255731141.1 SDR family oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-124)

Antitoxin

(9-46)


Sequences


Toxin        


Download         Length: 131 a.a.        Molecular weight: 14488.61 Da        Isoelectric Point: 6.9897

>T40019 WP_236981251.1 NZ_AP025179:c1174370-1173978 [Mycobacterium kiyosense]
VKRLLVDTHVWLWMQSDPGRLRDEARGLVADARNDVFLSAASAWEIAIKYRLGKLLLPETPATYVPDRMRRSGTSALPVE
HAHTLRTAALPDHHRDPFDRLIVAQAQLLNLTVVTADEQLSAYDVALVAA

Download         Length: 393 bp

>T40019 NZ_AP025179:c1174370-1173978 [Mycobacterium kiyosense]
GTGAAGCGTTTGCTGGTAGACACTCACGTCTGGCTGTGGATGCAGTCTGATCCCGGGCGGCTACGCGATGAAGCACGTGG
CCTCGTTGCGGACGCCCGCAACGACGTTTTCCTCTCCGCCGCCAGCGCCTGGGAGATCGCGATCAAATACCGCCTCGGCA
AACTCCTGTTGCCCGAAACCCCAGCCACGTACGTACCGGATCGAATGCGTCGTTCCGGAACATCTGCGCTACCGGTCGAA
CACGCTCACACGCTGCGCACCGCCGCGCTTCCAGACCATCACCGGGATCCGTTCGACCGCCTCATCGTCGCCCAGGCGCA
GCTACTCAACCTGACCGTCGTGACCGCCGATGAGCAACTGTCCGCCTACGACGTCGCGCTCGTCGCGGCGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9151.48 Da        Isoelectric Point: 6.2191

>AT40019 WP_236981252.1 NZ_AP025179:c1174612-1174367 [Mycobacterium kiyosense]
MTKSTVLRVGVHEAKTRMSELLRLVDSGQEIEIARSGEPVAKLVPFRPREIRRLGIDHGIYTVPDDFDAPLPDDVLQSFH
Q

Download         Length: 246 bp

>AT40019 NZ_AP025179:c1174612-1174367 [Mycobacterium kiyosense]
ATGACTAAGTCCACTGTGCTACGGGTCGGCGTCCACGAGGCGAAGACACGCATGTCGGAGCTGTTGCGACTGGTCGATAG
CGGGCAGGAGATCGAGATTGCGCGCAGTGGCGAACCCGTGGCAAAGCTGGTGCCATTTCGCCCGCGCGAGATCCGGCGCT
TGGGCATTGACCACGGCATATACACCGTGCCTGATGATTTCGACGCTCCGTTGCCAGACGATGTGCTGCAAAGCTTCCAT
CAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References