Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN-PHD |
Location | 1173978..1174612 | Replicon | chromosome |
Accession | NZ_AP025179 | ||
Organism | Mycobacterium kiyosense strain IWGMT90018-18076 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | L6444_RS05590 | Protein ID | WP_236981251.1 |
Coordinates | 1173978..1174370 (-) | Length | 131 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | L6444_RS05595 | Protein ID | WP_236981252.1 |
Coordinates | 1174367..1174612 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L6444_RS05565 (IWGMT90018_11440) | 1169156..1169731 | + | 576 | WP_236981248.1 | ECF RNA polymerase sigma factor SigD | - |
L6444_RS05570 (IWGMT90018_11450) | 1169724..1170644 | + | 921 | WP_236981249.1 | anti-sigma-D factor RsdA | - |
L6444_RS05575 (IWGMT90018_11460) | 1170661..1171074 | - | 414 | WP_236981250.1 | DUF5319 domain-containing protein | - |
L6444_RS05580 (IWGMT90018_11470) | 1171239..1172830 | + | 1592 | Protein_1107 | IMP dehydrogenase | - |
L6444_RS05585 (IWGMT90018_11490) | 1172845..1173972 | + | 1128 | WP_236983847.1 | GuaB3 family IMP dehydrogenase-related protein | - |
L6444_RS05590 (IWGMT90018_11500) | 1173978..1174370 | - | 393 | WP_236981251.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
L6444_RS05595 (IWGMT90018_11510) | 1174367..1174612 | - | 246 | WP_236981252.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
L6444_RS05600 (IWGMT90018_11520) | 1174685..1176430 | + | 1746 | WP_236981253.1 | GMC family oxidoreductase | - |
L6444_RS05605 (IWGMT90018_11530) | 1176658..1177347 | - | 690 | WP_236981254.1 | TetR/AcrR family transcriptional regulator | - |
L6444_RS05610 (IWGMT90018_11540) | 1177375..1178475 | + | 1101 | WP_236981255.1 | hypothetical protein | - |
L6444_RS30030 (IWGMT90018_11550) | 1178457..1179173 | - | 717 | WP_255731140.1 | hypothetical protein | - |
L6444_RS30035 (IWGMT90018_11560) | 1179199..1179369 | + | 171 | WP_255731141.1 | SDR family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14488.61 Da Isoelectric Point: 6.9897
>T40019 WP_236981251.1 NZ_AP025179:c1174370-1173978 [Mycobacterium kiyosense]
VKRLLVDTHVWLWMQSDPGRLRDEARGLVADARNDVFLSAASAWEIAIKYRLGKLLLPETPATYVPDRMRRSGTSALPVE
HAHTLRTAALPDHHRDPFDRLIVAQAQLLNLTVVTADEQLSAYDVALVAA
VKRLLVDTHVWLWMQSDPGRLRDEARGLVADARNDVFLSAASAWEIAIKYRLGKLLLPETPATYVPDRMRRSGTSALPVE
HAHTLRTAALPDHHRDPFDRLIVAQAQLLNLTVVTADEQLSAYDVALVAA
Download Length: 393 bp
>T40019 NZ_AP025179:c1174370-1173978 [Mycobacterium kiyosense]
GTGAAGCGTTTGCTGGTAGACACTCACGTCTGGCTGTGGATGCAGTCTGATCCCGGGCGGCTACGCGATGAAGCACGTGG
CCTCGTTGCGGACGCCCGCAACGACGTTTTCCTCTCCGCCGCCAGCGCCTGGGAGATCGCGATCAAATACCGCCTCGGCA
AACTCCTGTTGCCCGAAACCCCAGCCACGTACGTACCGGATCGAATGCGTCGTTCCGGAACATCTGCGCTACCGGTCGAA
CACGCTCACACGCTGCGCACCGCCGCGCTTCCAGACCATCACCGGGATCCGTTCGACCGCCTCATCGTCGCCCAGGCGCA
GCTACTCAACCTGACCGTCGTGACCGCCGATGAGCAACTGTCCGCCTACGACGTCGCGCTCGTCGCGGCGTGA
GTGAAGCGTTTGCTGGTAGACACTCACGTCTGGCTGTGGATGCAGTCTGATCCCGGGCGGCTACGCGATGAAGCACGTGG
CCTCGTTGCGGACGCCCGCAACGACGTTTTCCTCTCCGCCGCCAGCGCCTGGGAGATCGCGATCAAATACCGCCTCGGCA
AACTCCTGTTGCCCGAAACCCCAGCCACGTACGTACCGGATCGAATGCGTCGTTCCGGAACATCTGCGCTACCGGTCGAA
CACGCTCACACGCTGCGCACCGCCGCGCTTCCAGACCATCACCGGGATCCGTTCGACCGCCTCATCGTCGCCCAGGCGCA
GCTACTCAACCTGACCGTCGTGACCGCCGATGAGCAACTGTCCGCCTACGACGTCGCGCTCGTCGCGGCGTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9151.48 Da Isoelectric Point: 6.2191
>AT40019 WP_236981252.1 NZ_AP025179:c1174612-1174367 [Mycobacterium kiyosense]
MTKSTVLRVGVHEAKTRMSELLRLVDSGQEIEIARSGEPVAKLVPFRPREIRRLGIDHGIYTVPDDFDAPLPDDVLQSFH
Q
MTKSTVLRVGVHEAKTRMSELLRLVDSGQEIEIARSGEPVAKLVPFRPREIRRLGIDHGIYTVPDDFDAPLPDDVLQSFH
Q
Download Length: 246 bp
>AT40019 NZ_AP025179:c1174612-1174367 [Mycobacterium kiyosense]
ATGACTAAGTCCACTGTGCTACGGGTCGGCGTCCACGAGGCGAAGACACGCATGTCGGAGCTGTTGCGACTGGTCGATAG
CGGGCAGGAGATCGAGATTGCGCGCAGTGGCGAACCCGTGGCAAAGCTGGTGCCATTTCGCCCGCGCGAGATCCGGCGCT
TGGGCATTGACCACGGCATATACACCGTGCCTGATGATTTCGACGCTCCGTTGCCAGACGATGTGCTGCAAAGCTTCCAT
CAGTGA
ATGACTAAGTCCACTGTGCTACGGGTCGGCGTCCACGAGGCGAAGACACGCATGTCGGAGCTGTTGCGACTGGTCGATAG
CGGGCAGGAGATCGAGATTGCGCGCAGTGGCGAACCCGTGGCAAAGCTGGTGCCATTTCGCCCGCGCGAGATCCGGCGCT
TGGGCATTGACCACGGCATATACACCGTGCCTGATGATTTCGACGCTCCGTTGCCAGACGATGTGCTGCAAAGCTTCCAT
CAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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