Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2107887..2108416 Replicon chromosome
Accession NZ_AP025177
Organism Staphylococcus aureus strain TPS6281

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CC22TP_RS10435 Protein ID WP_000621175.1
Coordinates 2107887..2108249 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CC22TP_RS10440 Protein ID WP_000948330.1
Coordinates 2108246..2108416 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC22TP_RS10415 (2104865) 2104865..2105635 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
CC22TP_RS10420 (2105610) 2105610..2106089 - 480 WP_229346815.1 anti-sigma B factor RsbW -
CC22TP_RS10425 (2106091) 2106091..2106417 - 327 WP_001052491.1 anti-sigma factor antagonist -
CC22TP_RS10430 (2106537) 2106537..2107538 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
CC22TP_RS10435 (2107887) 2107887..2108249 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CC22TP_RS10440 (2108246) 2108246..2108416 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CC22TP_RS10445 (2108501) 2108501..2109649 - 1149 WP_001281141.1 alanine racemase -
CC22TP_RS10450 (2109715) 2109715..2110074 - 360 WP_000581193.1 holo-ACP synthase -
CC22TP_RS10455 (2110078) 2110078..2110569 - 492 WP_001205918.1 PH domain-containing protein -
CC22TP_RS10460 (2110556) 2110556..2112139 - 1584 WP_001294624.1 PH domain-containing protein -
CC22TP_RS10465 (2112132) 2112132..2112611 - 480 WP_001287080.1 hypothetical protein -
CC22TP_RS10470 (2112819) 2112819..2113379 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T40010 WP_000621175.1 NZ_AP025177:c2108249-2107887 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T40010 NZ_AP025177:c2108249-2107887 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT40010 WP_000948330.1 NZ_AP025177:c2108416-2108246 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT40010 NZ_AP025177:c2108416-2108246 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References