Detailed information of TA system TA040006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1895717..1896493
• Replicon: chromosome
• Accession: NZ_AP025177
• Organism: Staphylococcus aureus strain TPS6281

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: CC22TP_RS09145
• Protein ID: WP_000031112.1
• Coordinates: 1895717..1895869 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: CC22TP_RS09150
• Protein ID: WP_001251224.1
• Coordinates: 1895894..1896493 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CC22TP_RS09130 (1891622)	1891622..1892443	+	822	WP_000669382.1	RluA family pseudouridine synthase	-
CC22TP_RS09135 (1892906)	1892906..1894291	-	1386	WP_000116232.1	class II fumarate hydratase	-
CC22TP_RS09140 (1894487)	1894487..1894882	-	396	WP_000901023.1	hypothetical protein	-
CC22TP_RS09145 (1895717)	1895717..1895869	-	153	WP_000031112.1	SAS053 family protein	Toxin
CC22TP_RS09150 (1895894)	1895894..1896493	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
CC22TP_RS09155 (1896652)	1896652..1897122	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
CC22TP_RS09160 (1897127)	1897127..1898254	-	1128	WP_217654635.1	tRNA epoxyqueuosine(34) reductase QueG	-
CC22TP_RS09165 (1898404)	1898404..1899126	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
CC22TP_RS09170 (1899119)	1899119..1900576	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5966.31 Da
• Isoelectric Point: 3.8962

>T40006 WP_000031112.1 NZ_AP025177:c1895869-1895717 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELSKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T40006 NZ_AP025177:c1895869-1895717 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAAGTAAAGAAATGGAACAAATTTCCGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT40006 WP_001251224.1 NZ_AP025177:c1896493-1895894 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT40006 NZ_AP025177:c1896493-1895894 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4