Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 803487..803964 Replicon chromosome
Accession NZ_AP025177
Organism Staphylococcus aureus strain TPS6281

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CC22TP_RS03725 Protein ID WP_000052076.1
Coordinates 803487..803675 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CC22TP_RS03730 Protein ID WP_001059690.1
Coordinates 803704..803964 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC22TP_RS03695 (799477) 799477..799998 + 522 WP_000824488.1 hypothetical protein -
CC22TP_RS03700 (800339) 800339..801025 + 687 WP_001670297.1 thermonuclease family protein -
CC22TP_RS03705 (801382) 801382..801582 + 201 WP_001059082.1 cold-shock protein -
CC22TP_RS03710 (802078) 802078..802296 - 219 WP_000005876.1 hypothetical protein -
CC22TP_RS03715 (802358) 802358..802642 - 285 WP_001004395.1 hypothetical protein -
CC22TP_RS03720 (802730) 802730..803299 - 570 WP_001106646.1 lipoprotein N-acylation protein LnsA -
CC22TP_RS03725 (803487) 803487..803675 - 189 WP_000052076.1 hypothetical protein Toxin
CC22TP_RS03730 (803704) 803704..803964 - 261 WP_001059690.1 hypothetical protein Antitoxin
CC22TP_RS03735 (804304) 804304..804507 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CC22TP_RS03740 (804504) 804504..804740 - 237 WP_000368687.1 hypothetical protein -
CC22TP_RS03745 (804965) 804965..805546 + 582 WP_001140696.1 histidine phosphatase family protein -
CC22TP_RS03750 (805619) 805619..806236 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
CC22TP_RS03755 (806389) 806389..806883 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
CC22TP_RS03760 (807282) 807282..807704 - 423 WP_229346843.1 organic hydroperoxide resistance protein -
CC22TP_RS03765 (807852) 807852..808568 + 717 WP_229346844.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-150)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(28-90)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T40003 WP_000052076.1 NZ_AP025177:c803675-803487 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T40003 NZ_AP025177:c803675-803487 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT40003 WP_001059690.1 NZ_AP025177:c803964-803704 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT40003 NZ_AP025177:c803964-803704 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References