Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2151230..2151759 Replicon chromosome
Accession NZ_AP025176
Organism Staphylococcus aureus strain TPS5614

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPC25_RS10700 Protein ID WP_000621175.1
Coordinates 2151230..2151592 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LPC25_RS10705 Protein ID WP_000948330.1
Coordinates 2151589..2151759 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC25_RS10680 (2148209) 2148209..2148979 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
LPC25_RS10685 (2148954) 2148954..2149433 - 480 WP_001190825.1 anti-sigma B factor RsbW -
LPC25_RS10690 (2149435) 2149435..2149761 - 327 WP_001052491.1 anti-sigma factor antagonist -
LPC25_RS10695 (2149881) 2149881..2150882 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPC25_RS10700 (2151230) 2151230..2151592 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPC25_RS10705 (2151589) 2151589..2151759 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPC25_RS10710 (2151844) 2151844..2152992 - 1149 WP_001281141.1 alanine racemase -
LPC25_RS10715 (2153058) 2153058..2153417 - 360 WP_000581193.1 holo-ACP synthase -
LPC25_RS10720 (2153421) 2153421..2153912 - 492 WP_001205918.1 PH domain-containing protein -
LPC25_RS10725 (2153899) 2153899..2155482 - 1584 WP_001294624.1 PH domain-containing protein -
LPC25_RS10730 (2155475) 2155475..2155954 - 480 WP_001287080.1 hypothetical protein -
LPC25_RS10735 (2156163) 2156163..2156723 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T39994 WP_000621175.1 NZ_AP025176:c2151592-2151230 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T39994 NZ_AP025176:c2151592-2151230 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT39994 WP_000948330.1 NZ_AP025176:c2151759-2151589 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT39994 NZ_AP025176:c2151759-2151589 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References