Detailed information of TA system TA039990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1939502..1940278
• Replicon: chromosome
• Accession: NZ_AP025176
• Organism: Staphylococcus aureus strain TPS5614

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: LPC25_RS09420
• Protein ID: WP_000031112.1
• Coordinates: 1939502..1939654 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: LPC25_RS09425
• Protein ID: WP_001251224.1
• Coordinates: 1939679..1940278 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPC25_RS09405 (1935407)	1935407..1936228	+	822	WP_000669382.1	RluA family pseudouridine synthase	-
LPC25_RS09410 (1936691)	1936691..1938076	-	1386	WP_000116232.1	class II fumarate hydratase	-
LPC25_RS09415 (1938272)	1938272..1938667	-	396	WP_000901023.1	hypothetical protein	-
LPC25_RS09420 (1939502)	1939502..1939654	-	153	WP_000031112.1	SAS053 family protein	Toxin
LPC25_RS09425 (1939679)	1939679..1940278	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
LPC25_RS09430 (1940437)	1940437..1940907	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LPC25_RS09435 (1940912)	1940912..1942039	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
LPC25_RS09440 (1942189)	1942189..1942911	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
LPC25_RS09445 (1942904)	1942904..1944010	-	1107	Protein_1856	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5966.31 Da
• Isoelectric Point: 3.8962

>T39990 WP_000031112.1 NZ_AP025176:c1939654-1939502 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELSKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T39990 NZ_AP025176:c1939654-1939502 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAAGTAAAGAAATGGAACAAATTTCCGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT39990 WP_001251224.1 NZ_AP025176:c1940278-1939679 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT39990 NZ_AP025176:c1940278-1939679 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4