Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 843264..843741 Replicon chromosome
Accession NZ_AP025176
Organism Staphylococcus aureus strain TPS5614

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LPC25_RS03960 Protein ID WP_000052076.1
Coordinates 843264..843452 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LPC25_RS03965 Protein ID WP_001059690.1
Coordinates 843481..843741 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC25_RS03930 (839254) 839254..839775 + 522 WP_000824488.1 hypothetical protein -
LPC25_RS03935 (840116) 840116..840802 + 687 WP_001670297.1 thermonuclease family protein -
LPC25_RS03940 (841159) 841159..841359 + 201 WP_001059082.1 cold-shock protein -
LPC25_RS03945 (841855) 841855..842073 - 219 WP_000005876.1 hypothetical protein -
LPC25_RS03950 (842135) 842135..842419 - 285 WP_001004395.1 hypothetical protein -
LPC25_RS03955 (842507) 842507..843076 - 570 WP_001106646.1 lipoprotein N-acylation protein LnsA -
LPC25_RS03960 (843264) 843264..843452 - 189 WP_000052076.1 hypothetical protein Toxin
LPC25_RS03965 (843481) 843481..843741 - 261 WP_001059690.1 hypothetical protein Antitoxin
LPC25_RS03970 (844081) 844081..844284 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LPC25_RS03975 (844281) 844281..844517 - 237 WP_000368687.1 hypothetical protein -
LPC25_RS03980 (844742) 844742..845323 + 582 WP_001140696.1 histidine phosphatase family protein -
LPC25_RS03985 (845396) 845396..846013 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
LPC25_RS03990 (846166) 846166..846660 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
LPC25_RS03995 (847059) 847059..847481 - 423 WP_229338632.1 organic hydroperoxide resistance protein -
LPC25_RS04000 (847629) 847629..848345 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 / sec / sell / vWbp 810737..849937 39200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T39987 WP_000052076.1 NZ_AP025176:c843452-843264 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T39987 NZ_AP025176:c843452-843264 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT39987 WP_001059690.1 NZ_AP025176:c843741-843481 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT39987 NZ_AP025176:c843741-843481 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References