Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 530267..530832 Replicon plasmid pMTS1
Accession NZ_AP025172
Organism Cupriavidus sp. P-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CTP10_RS32395 Protein ID WP_116323108.1
Coordinates 530461..530832 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CTP10_RS32390 Protein ID WP_022540311.1
Coordinates 530267..530464 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTP10_RS32375 (CTP10_R64720) 525567..527393 - 1827 WP_116323111.1 polysaccharide deacetylase family protein -
CTP10_RS32380 (CTP10_R64730) 527501..527869 - 369 WP_116323110.1 hypothetical protein -
CTP10_RS32385 (CTP10_R64740) 527964..529148 - 1185 WP_116323109.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
CTP10_RS32390 (CTP10_R64760) 530267..530464 + 198 WP_022540311.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CTP10_RS32395 (CTP10_R64770) 530461..530832 + 372 WP_116323108.1 type II toxin-antitoxin system VapC family toxin Toxin
CTP10_RS32400 (CTP10_R64780) 530924..531172 - 249 WP_233528398.1 hypothetical protein -
CTP10_RS32405 (CTP10_R64790) 531662..531979 + 318 WP_116323107.1 H-NS histone family protein -
CTP10_RS32410 (CTP10_R64800) 532846..533382 - 537 Protein_465 transposase -
CTP10_RS32415 (CTP10_R64810) 534661..535461 + 801 WP_271815750.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / htpB 1..1635938 1635938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13595.75 Da        Isoelectric Point: 4.8675

>T39984 WP_116323108.1 NZ_AP025172:530461-530832 [Cupriavidus sp. P-10]
MILVDTSVWIDHINASDPMLISLLAEERVLAHPYVIGEISLGSLRDRDVVLGALLDLPRAPVATPEETFYLIEREGLFNR
GIGYIDTSLLASARLQPGITIWTHDKRLKKVADELNLGAVLAH

Download         Length: 372 bp

>T39984 NZ_AP025172:530461-530832 [Cupriavidus sp. P-10]
ATGATTCTGGTCGACACGTCGGTCTGGATTGACCACATCAACGCTTCTGATCCTATGCTGATTAGCCTGCTTGCCGAGGA
GCGTGTGCTGGCTCATCCCTATGTGATAGGCGAGATTTCGCTCGGTAGTCTGCGTGACCGTGACGTCGTGCTTGGCGCGT
TGCTCGATCTGCCACGCGCGCCAGTTGCGACGCCGGAGGAGACGTTTTATTTGATCGAGCGCGAAGGGTTGTTCAATCGT
GGAATAGGATATATCGACACGTCACTCCTGGCGTCCGCGCGCCTACAACCAGGCATCACCATCTGGACGCACGACAAGCG
ATTGAAGAAGGTTGCCGATGAACTTAATCTCGGCGCGGTGCTTGCGCACTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7102.19 Da        Isoelectric Point: 10.3509

>AT39984 WP_022540311.1 NZ_AP025172:530267-530464 [Cupriavidus sp. P-10]
MRTTIALDDDLIAKAQAYTGLEEKTALVREALKALIQREAAKRLANLGGSQPGIKGAPRRRQDIE

Download         Length: 198 bp

>AT39984 NZ_AP025172:530267-530464 [Cupriavidus sp. P-10]
ATGCGTACGACTATTGCGCTTGATGACGACTTGATCGCCAAGGCTCAAGCCTATACGGGCCTGGAGGAGAAAACGGCACT
CGTGCGCGAAGCACTAAAGGCCTTGATCCAGCGTGAAGCCGCGAAACGACTCGCGAATCTTGGCGGTAGCCAACCGGGCA
TCAAGGGGGCACCGCGTCGCCGGCAGGACATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References