Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 2008657..2009225 Replicon chromosome
Accession NZ_AP025170
Organism Cupriavidus sp. P-10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CTP10_RS09225 Protein ID WP_116320580.1
Coordinates 2008657..2008905 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CTP10_RS09230 Protein ID WP_116320579.1
Coordinates 2008899..2009225 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTP10_RS09195 (CTP10_R18420) 2004021..2004779 - 759 WP_199414618.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -
CTP10_RS09200 (CTP10_R18430) 2004911..2005180 + 270 WP_116320585.1 acyl-CoA-binding protein -
CTP10_RS09205 (CTP10_R18440) 2005211..2006692 - 1482 WP_116320584.1 DHA2 family efflux MFS transporter permease subunit -
CTP10_RS09210 (CTP10_R18450) 2006689..2007159 - 471 WP_116320583.1 SRPBCC family protein -
CTP10_RS09215 (CTP10_R18460) 2007303..2007977 + 675 WP_116320582.1 SGNH/GDSL hydrolase family protein -
CTP10_RS09220 (CTP10_R18470) 2008098..2008505 + 408 WP_116320581.1 VOC family protein -
CTP10_RS09225 (CTP10_R18480) 2008657..2008905 + 249 WP_116320580.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
CTP10_RS09230 (CTP10_R18490) 2008899..2009225 + 327 WP_116320579.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
CTP10_RS09235 (CTP10_R18500) 2009418..2010230 + 813 WP_116320578.1 MetQ/NlpA family ABC transporter substrate-binding protein -
CTP10_RS09245 (CTP10_R18520) 2010467..2011276 - 810 WP_233528192.1 substrate-binding domain-containing protein -
CTP10_RS09250 (CTP10_R18530) 2011521..2012420 + 900 WP_116320747.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(4-103)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9030.30 Da        Isoelectric Point: 4.3322

>T39981 WP_116320580.1 NZ_AP025170:2008657-2008905 [Cupriavidus sp. P-10]
MKATIRKMGNSQGVLIPKAILAQLGLEDEVEMDIVNDTLVIRRPRNTPREGWAEASRAIAEAGDDVLVLGEFPNADDAEL
KW

Download         Length: 249 bp

>T39981 NZ_AP025170:2008657-2008905 [Cupriavidus sp. P-10]
ATGAAAGCGACGATCCGAAAAATGGGCAACTCACAGGGGGTCCTGATCCCCAAGGCAATCCTGGCGCAACTGGGCCTGGA
GGATGAAGTGGAAATGGATATCGTGAACGACACGCTGGTGATTCGGCGGCCGAGAAATACGCCACGCGAAGGCTGGGCCG
AAGCGAGCCGCGCCATTGCCGAAGCCGGTGACGATGTGCTGGTTCTGGGCGAATTTCCCAACGCGGACGATGCGGAGCTG
AAATGGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12178.20 Da        Isoelectric Point: 10.5686

>AT39981 WP_116320579.1 NZ_AP025170:2008899-2009225 [Cupriavidus sp. P-10]
MVVRGEVWLVALDPAVGSEIRKARPCVVVSPPEMHDYLRTVTVAPMTSGSRPAPFRVGVTFQRRHGLILLDQIRAVDKSR
LIKRAGELNENTLRETLRVLRECFADQN

Download         Length: 327 bp

>AT39981 NZ_AP025170:2008899-2009225 [Cupriavidus sp. P-10]
ATGGTAGTGCGGGGTGAGGTCTGGCTTGTAGCCCTTGACCCAGCCGTAGGCAGCGAAATCAGGAAGGCGCGCCCGTGCGT
CGTCGTCTCGCCGCCGGAGATGCATGACTACCTGCGAACAGTCACCGTTGCTCCCATGACTTCCGGTAGCCGGCCCGCAC
CCTTCCGGGTCGGCGTGACGTTCCAGCGCAGGCACGGGCTGATTCTCCTCGACCAGATTCGTGCCGTCGACAAATCTCGA
CTGATAAAGCGGGCTGGGGAACTCAATGAGAACACCCTGCGCGAAACCCTTCGCGTCTTGCGCGAGTGCTTCGCCGACCA
GAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References