39980

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5785452..5786494 Replicon chromosome
Accession NZ_AP025169
Organism Pseudomonas sp. CYM-20-01

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M2497_RS26300 Protein ID WP_248484256.1
Coordinates 5785452..5786027 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag M2497_RS26305 Protein ID WP_248484258.1
Coordinates 5786024..5786494 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2497_RS26265 (cym2001_51820) 5781484..5781864 + 381 WP_248484230.1 cupin domain-containing protein -
M2497_RS26270 (cym2001_51830) 5781973..5782257 - 285 WP_201026013.1 hypothetical protein -
M2497_RS26275 (cym2001_51840) 5782532..5782861 + 330 WP_248484232.1 hypothetical protein -
M2497_RS26280 (cym2001_51850) 5782870..5783505 - 636 WP_248484234.1 LysE family translocator -
M2497_RS26285 (cym2001_51860) 5783645..5784016 + 372 WP_071496425.1 PH domain-containing protein -
M2497_RS26290 (cym2001_51870) 5784114..5784422 - 309 WP_248484236.1 DUF3077 domain-containing protein -
M2497_RS26295 (cym2001_51880) 5784878..5785264 + 387 WP_248484238.1 hypothetical protein -
M2497_RS26300 (cym2001_51890) 5785452..5786027 - 576 WP_248484256.1 PIN domain-containing protein Toxin
M2497_RS26305 (cym2001_51900) 5786024..5786494 - 471 WP_248484258.1 helix-turn-helix domain-containing protein Antitoxin
M2497_RS26310 (cym2001_51910) 5786622..5786849 - 228 WP_248488259.1 hypothetical protein -
M2497_RS26315 (cym2001_51920) 5786846..5787358 - 513 WP_248484261.1 type VI secretion system amidase effector protein Tae4 -
M2497_RS26320 (cym2001_51930) 5787638..5788795 + 1158 WP_248484263.1 S-type pyocin domain-containing protein -
M2497_RS26325 (cym2001_51940) 5788809..5789096 + 288 WP_248484265.1 colicin E3-like toxin immunity protein -
M2497_RS26330 5789101..5789316 + 216 Protein_5195 colicin E3/pyocin S6 family cytotoxin -
M2497_RS26335 (cym2001_51950) 5789331..5789618 + 288 WP_248484267.1 colicin E3-like toxin immunity protein -
M2497_RS26340 (cym2001_51960) 5789623..5790105 + 483 WP_248484269.1 hypothetical protein -
M2497_RS26345 (cym2001_51970) 5790109..5790675 - 567 WP_071496422.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21605.99 Da        Isoelectric Point: 5.2869

>T39980 WP_248484256.1 NZ_AP025169:c5786027-5785452 [Pseudomonas sp. CYM-20-01]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTRQIHEEWKRNVLKNRPDLTAEQVNCTSALMDKAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPAHILSAYDIEPMHPDDFISDLWDLDQAAVLGAAQKQRRALKR
PPMEAGSYLEMLMRQGLVQTSKVLGPYELML

Download         Length: 576 bp

>T39980 NZ_AP025169:c5786027-5785452 [Pseudomonas sp. CYM-20-01]
ATGAGGTGTTCGCCTTTTACTGCTGTATACGATGCTTGTGTTCTTTACCCGGCAGCGCTTCGGGATTTACTGATGTGGCT
TGGCTTGTCAGGGCTGTATCGAGCGAGATGGACCCGCCAGATTCATGAGGAGTGGAAGCGCAACGTACTCAAGAACCGGC
CCGATCTGACGGCGGAGCAAGTGAATTGCACGTCAGCGCTGATGGACAAGGCTATACCTGACGCTTTGGTGACGGGATAT
GAGGATCTGTGCTCGAGTCTGGATCTGCCCGATCCAGATGATCGTCACGTGCTGGCGGCGGCAATTCGGAGCAAAGCTGA
GGTTATCGTGACGTTCAATTTGAAAGATTTCCCGGCGCACATTCTGTCTGCTTATGATATTGAGCCGATGCATCCAGATG
ACTTTATTTCGGATCTTTGGGATCTGGATCAGGCGGCGGTGCTGGGAGCGGCGCAGAAGCAGAGGCGGGCGTTGAAGCGG
CCTCCGATGGAGGCGGGGAGTTATCTTGAGATGTTGATGCGGCAGGGGTTGGTGCAGACTAGTAAGGTGCTGGGGCCTTA
TGAGTTGATGCTGTAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17409.02 Da        Isoelectric Point: 5.6324

>AT39980 WP_248484258.1 NZ_AP025169:c5786494-5786024 [Pseudomonas sp. CYM-20-01]
MMANHLPKTIPPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHSLVLPTSALRLLVDILGELAIGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRDEESQEAMEALAQQAQELGMGYDG

Download         Length: 471 bp

>AT39980 NZ_AP025169:c5786494-5786024 [Pseudomonas sp. CYM-20-01]
ATGATGGCCAATCACCTCCCTAAAACCATTCCTCCTCTGGAAAAGGAAGTCGAAGCTGCCGTACAAGGCCAGCGTGAGCT
GGCCTCGCTGCTGTCGACCAAATTTGAAACCCAGCGCATCGACATCTTCGACAAAGAAGATAAGCCTCACAGCCTCGTAC
TCCCCACCTCAGCACTGCGCTTGCTGGTCGATATTTTGGGCGAGTTAGCGATCGGCAATGCGGTCAAGGTAGTCCCGGTG
CACGCTGAATTGACATCGCAGGAAGCGGCTGACCTGCTTAACGTTTCACGGCCGCACTTGGTCAAGATGCTGGAGGAGGG
CGCTATTCCCTTTACAAAAACCGGTCGGCATCGACGCATCCGTTTTTCGGACTTGATGGCGTTCAAGCAGCGGAGGGATG
AGGAAAGTCAGGAGGCGATGGAAGCGTTGGCACAACAGGCACAGGAGTTGGGAATGGGGTATGACGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References